2025-08-01
Evaluating a predictive model of tyrosine kinase inhibitor therapy failure in a European-type cohort: a step towards population-specific tools
2025-08-01 • Sylvain Moinard, Benjamin Lebecque, Tom Lachaise, Hyacinthe Johnson‐Ansah, Charlotte Doublet, Gabrielle Roth-Guépin, Françoise Rigal‐Huguet, Lydia...
Predicting therapeutic failure in patients with chronic phase-chronic myeloid leukemia (CP-CML) treated with tyrosine kinase inhibitors (TKI) remains a major challenge for personalized care management. The Sokal and EUTOS long-term survival scores were designed to predict CML-related mortality, but are also used to guide therapeutic choices, despite their poor performance for this purpose. A recent study proposed a refined predictive model of therapy failure specifically tailored for patients treated with imatinib…