Charlotte Sleurs
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View article: Biomarker-based profiling of fatigue in childhood cancer survivors: evidence for distinct inflammatory and glial-associated profiles
Biomarker-based profiling of fatigue in childhood cancer survivors: evidence for distinct inflammatory and glial-associated profiles Open
View article: Neuropsychological functioning in non-CNS cancer patients
Neuropsychological functioning in non-CNS cancer patients Open
While these more personalized interventions might hold promise for CRCI, further research is needed to determine their true efficacy, particularly considering the potential influence of practice effects. Additionally, in-depth, large-scale…
View article: Radiotherapy-induced neurocognitive decline among adult intracranial tumor patients: A voxel-based approach
Radiotherapy-induced neurocognitive decline among adult intracranial tumor patients: A voxel-based approach Open
Background Cranial irradiation is a key component of neuro-oncological treatment but can result in cognitive side effects. Preserving cognition from radiotherapy-(RT)-induced toxicity remains an ongoing debate. To spatially map radiotoxic …
View article: The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions
The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions Open
Background Emerging evidence suggests that cognitive dysfunction may result from damage to the brain’s functional network. This study explores the dose-dependent susceptibility of functional hubs to radiotherapy (RT) and associations with …
View article: Identity formation, personality, and well-being in adolescent and emerging adult siblings of survivors of pediatric cancer
Identity formation, personality, and well-being in adolescent and emerging adult siblings of survivors of pediatric cancer Open
Background: Siblings of pediatric cancer survivors are increasingly recognized as a potential vulnerable group requiring focused psychosocial support. However, little is known whether the experience of having a sibling with cancer affects …
View article: Quality of Life Priorities of Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC Studies, and a Comparison of Instruments
Quality of Life Priorities of Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC Studies, and a Comparison of Instruments Open
Purpose Survivors of childhood cancer can suffer from long‐term sequelae or decline in quality of life (QoL), for which careful and standardized selection of outcome measures become more important. This study aims to assess different QoL‐r…
View article: A systematic review of interventions for neurocognitive dysfunctions in patients and survivors of a pediatric brain tumor.
A systematic review of interventions for neurocognitive dysfunctions in patients and survivors of a pediatric brain tumor. Open
Due to a high burden of neurocognitive impairment on patients with a pediatric brain tumor, interventions mitigating these symptoms are highly needed. Currently, evidence on the efficacy and feasibility of such interventions remain scarce.…
View article: IMG-17. CHANGES IN GRAY MATTER VOLUMES AND THEIR RELATION WITH NEUROPSYCHOLOGICAL DOMAIN SCORES IN SURVIVORS OF A CHILDHOOD POSTERIOR FOSSA TUMOR
IMG-17. CHANGES IN GRAY MATTER VOLUMES AND THEIR RELATION WITH NEUROPSYCHOLOGICAL DOMAIN SCORES IN SURVIVORS OF A CHILDHOOD POSTERIOR FOSSA TUMOR Open
Posterior fossa tumors (PFT) often need neurotoxic radiotherapy (RT). These may affect the brain and contribute to neurocognitive impairment later in life. Therefore, we investigated region-based gray matter volumes (GMV) and their relatio…
View article: Changes in leukoencephalopathy and serum neurofilament after (neo)adjuvant chemotherapy for breast cancer
Changes in leukoencephalopathy and serum neurofilament after (neo)adjuvant chemotherapy for breast cancer Open
View article: Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations
Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations Open
View article: Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis
Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis Open
Background Cognitive functioning is increasingly assessed as a secondary outcome in neuro-oncological trials. However, which cognitive domains or tests to assess, remains debatable. In this meta-analysis, we aimed to elucidate the longer-t…
View article: A Systematic Review on the Potential Acceleration of Neurocognitive Aging in Older Cancer Survivors
A Systematic Review on the Potential Acceleration of Neurocognitive Aging in Older Cancer Survivors Open
As survival rates increase, more emphasis has gone to possible cognitive sequelae in older cancer patients, which could be explained by accelerated brain aging. In this review, we provide a complete overview of studies investigating neuroi…
View article: Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia; a meta‐analysis
Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia; a meta‐analysis Open
Objective This meta‐analysis assesses cognitive functioning in children with acute lymphoblastic leukemia post‐treatment who were treated with either chemotherapy‐only (CT‐only) or in combination with radiation therapy (CTRT). Methods The …
View article: Physical fitness throughout chemotherapy in children with acute lymphoblastic leukaemia and lymphoma
Physical fitness throughout chemotherapy in children with acute lymphoblastic leukaemia and lymphoma Open
View article: Neurocognition in adults with intracranial tumors: does location really matter?
Neurocognition in adults with intracranial tumors: does location really matter? Open
Objective As preservation of cognitive functioning increasingly becomes important in the light of ameliorated survival after intracranial tumor treatments, identification of eloquent brain areas would enable optimization of these treatment…
View article: Quality of life of long‐term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls
Quality of life of long‐term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls Open
Objective Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long‐term quality of life (QoL) and domains of com…
View article: Cancer-related cognitive impairment in non-CNS cancer patients: Targeted review and future action plans in Europe
Cancer-related cognitive impairment in non-CNS cancer patients: Targeted review and future action plans in Europe Open
View article: Correction to: Better detection of reduced motor functioning in brain tumor survivors based on objective motor assessments: an incentive for improved standardized follow-up
Correction to: Better detection of reduced motor functioning in brain tumor survivors based on objective motor assessments: an incentive for improved standardized follow-up Open
View article: Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring
Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring Open
Background. The connectome, constituting a unique fingerprint of a person’s brain, may be influenced by its prenatal environment, potentially affecting later-life resilience and mental health. Methods. We conducted a prospective resting-st…
View article: QOL-16. A 6-year longitudinal study of neurocognition in children treated for a brain tumor
QOL-16. A 6-year longitudinal study of neurocognition in children treated for a brain tumor Open
Long-term neurocognitive difficulties in children treated for a brain tumor are well documented and known to be affected by treatment. However, longitudinal studies of these neurocognitive difficulties are scarce. In the present study, we …
View article: Better detection of reduced motor functioning in brain tumor survivors based on objective motor assessments: an incentive for improved standardized follow-up
Better detection of reduced motor functioning in brain tumor survivors based on objective motor assessments: an incentive for improved standardized follow-up Open
View article: Recommendations for the surveillance of education and employment outcomes in survivors of childhood, adolescent, and young adult cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Recommendations for the surveillance of education and employment outcomes in survivors of childhood, adolescent, and young adult cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group Open
Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guidelin…
View article: Neuroinflammation as potential precursor of leukoencephalopathy in early-stage breast cancer patients: A cross-sectional PET-MRI study
Neuroinflammation as potential precursor of leukoencephalopathy in early-stage breast cancer patients: A cross-sectional PET-MRI study Open
View article: Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies
Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies Open
Background: due to increasing survival rates in childhood acute lymphoblastic leukemia (ALL), the number of survivors has been expanding. A significant proportion of these survivors can experience long-term emotional and psychosocial probl…
View article: Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review
Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review Open
View article: Long term fMRI adaptation depends on adapter response in face-selective cortex
Long term fMRI adaptation depends on adapter response in face-selective cortex Open
Repetition suppression (RS) reflects a neural attenuation during repeated stimulation. We used fMRI and the subsequent memory paradigm to test the predictive coding hypothesis for RS during visual memory processing by investigating the int…
View article: Brain network hubs and cognitive performance of survivors of childhood infratentorial tumors
Brain network hubs and cognitive performance of survivors of childhood infratentorial tumors Open
View article: Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors
Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors Open
This retrospective correlation study investigated the putative link between methylene tetrahydrofolate reductase (MTHFR) A1298C mutations and chemotherapy-related brain function changes in adult childhood-leukemia survivors. To this end, w…
View article: Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment
Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment Open
Pediatric cancer and its treatment are associated with increased risk for acute and chronic cognitive impairments. Neuroimaging studies indicate a common biologic pathway of candidate mechanisms underlying these impairments is diffuse brai…
View article: Age- and Intravenous Methotrexate-Associated Leukoencephalopathy and Its Neurological Impact in Pediatric Patients with Lymphoblastic Leukemia
Age- and Intravenous Methotrexate-Associated Leukoencephalopathy and Its Neurological Impact in Pediatric Patients with Lymphoblastic Leukemia Open
Methotrexate (MTX) is associated with leukoencephalopathy (LE) in children treated for lymphoblastic leukemia/lymphoma (ALL/LBL). However, large-scale studies with systematic MR acquisition and quantitative volumetric lesion information re…