Charly Gaul
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View article: Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine
Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine Open
Importance Placebo effects contribute substantially to the therapeutic success of many treatments, particularly in pain-related conditions. Open-label placebos (OLPs) offer an ethically acceptable approach to harness this potential without…
View article: Welche Migränepatienten werden mit CGRP(R)-Antikörpern behandelt?
Welche Migränepatienten werden mit CGRP(R)-Antikörpern behandelt? Open
Zusammenfassung Hintergrund Antikörper gegen CGRP oder seinen Rezeptor (Eptinezumab, Erenumab, Fremanezumab, Galcanezumab, im Folgenden: „CGRP(R)-Antikörper“) sind moderne, spezifische Migräneprophylaktika, die im GKV-Bereich nur für thera…
View article: Efficacy and safety of kinetic oscillation stimulation in the nasal cavity for the treatment of acute migraine attacks: A randomized, placebo-controlled, double-blind investigation
Efficacy and safety of kinetic oscillation stimulation in the nasal cavity for the treatment of acute migraine attacks: A randomized, placebo-controlled, double-blind investigation Open
Background Migraine attacks present a problem for patients who are unable to benefit from drug treatment. The Chordate System S020 delivers kinetic oscillation to the nasal mucosa, which is supposed to modulate the parasympathetic outflow …
View article: Psychological transdiagnostic factors and migraine characteristics as predictors of migraine-related disability
Psychological transdiagnostic factors and migraine characteristics as predictors of migraine-related disability Open
Background Migraine is a prevalent primary headache disorder that significantly impairs daily life. Research on factors contributing to migraine-related disability remains limited, particularly from a biopsychosocial perspective. This stud…
View article: Identifying cognitive‐affective mechanisms underlying disability in episodic migraine: Using the fear avoidance model to examine interactions
Identifying cognitive‐affective mechanisms underlying disability in episodic migraine: Using the fear avoidance model to examine interactions Open
Objective Using the fear‐avoidance model (FAM) as a theoretical framework, this study examined the interactions between empirical factors contributing to disability in episodic migraine. It was tested whether pain catastrophizing, fear of …
View article: Real-World Safety and Efficacy of 156 U – 195 U OnabotulinumtoxinA in Adults With Chronic Migraine: Results From the REPOSE Study
Real-World Safety and Efficacy of 156 U – 195 U OnabotulinumtoxinA in Adults With Chronic Migraine: Results From the REPOSE Study Open
View article: Der DMKG-Kopfschmerzfragebogen
Der DMKG-Kopfschmerzfragebogen Open
Zusammenfassung Für die Diagnosestellung, Therapie und Verlaufsbeurteilung von Kopfschmerzerkrankungen müssen in der Anamnese zahlreiche Informationen erfragt werden. Dies wird wesentlich erleichtert, wenn die Patient:innen diese Informati…
View article: Kinetic Oscillation Stimulation for the Preventive Treatment of Chronic Migraine
Kinetic Oscillation Stimulation for the Preventive Treatment of Chronic Migraine Open
This study provides Class I evidence that weekly intranasal K.O.S is associated with a reduced number of headache days per month in patients with CM.
View article: Efficacy of Digital Therapeutic sinCephalea for Personalised Nutrition Versus Control for Migraine Prevention: A 12-Week Open-Label Randomised Clinical Trial
Efficacy of Digital Therapeutic sinCephalea for Personalised Nutrition Versus Control for Migraine Prevention: A 12-Week Open-Label Randomised Clinical Trial Open
View article: German language adaptation of the Cluster Headache Quality of Life Scale (CH-QoL)
German language adaptation of the Cluster Headache Quality of Life Scale (CH-QoL) Open
Background Cluster headache (CH) can lead to high disability and reduced quality of life (QoL). QoL should be assessed as an important outcome both in research and in clinical care. The 28-item Cluster Headache Quality of Life Scale (CH-Qo…
View article: Real-World Experience of Erenumab in Patients with Migraine in Germany: The SPECTRE Study
Real-World Experience of Erenumab in Patients with Migraine in Germany: The SPECTRE Study Open
Most patients with migraine were prescribed erenumab 70 mg as the starting dose. No new safety signals were observed for erenumab versus the previous trials.
View article: Household income is associated with attack frequency, but not with the prevalence of headache: an analysis of self-reported headache in the general population in Germany
Household income is associated with attack frequency, but not with the prevalence of headache: an analysis of self-reported headache in the general population in Germany Open
View article: The impact of fear of attacks on pain‐related disability in cluster headache: Insights from the fear avoidance model
The impact of fear of attacks on pain‐related disability in cluster headache: Insights from the fear avoidance model Open
Objective This study utilized the theoretical framework of the “fear avoidance model” (FAM) and investigated the role of fear of attack in pain‐related disability. To this end, a measurement specific to cluster headache (CH) was used to in…
View article: German language adaptation of the Cogniphobia Scale for Headache Disorders ( <scp>CS‐HD</scp> ) and development of a new short form ( <scp>CS‐HD</scp> ‐6)
German language adaptation of the Cogniphobia Scale for Headache Disorders ( <span>CS‐HD</span> ) and development of a new short form ( <span>CS‐HD</span> ‐6) Open
Objective This study is part of the ODIN‐migraine (Optimization of Diagnostic Instruments in migraine) project. It is a secondary, a priori analysis of previously collected data, and aimed to assess the psychometric properties and factor s…
View article: Correlation of effectiveness and tolerability assessments from a pharmacy-based observational study investigating the fixed-dose combination of 400 mg ibuprofen plus 100 mg caffeine for the treatment of acute headache
Correlation of effectiveness and tolerability assessments from a pharmacy-based observational study investigating the fixed-dose combination of 400 mg ibuprofen plus 100 mg caffeine for the treatment of acute headache Open
Introduction Observational studies are valuable for investigating correlations between patient-reported treatment outcomes. In this study, we report a secondary analysis of a published pharmacy-based observational (patient-centered “real-w…
View article: Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry
Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry Open
View article: Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article
Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article Open
View article: Therapeutic Exercise Parameters, Considerations, and Recommendations for Migraine Treatment: An International Delphi Study
Therapeutic Exercise Parameters, Considerations, and Recommendations for Migraine Treatment: An International Delphi Study Open
Objective The goal of this study was to reach consensus about the best exercise prescription parameters, the most relevant considerations, and other recommendations that could be useful for prescribing exercise to patients with migraine. M…
View article: Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial
Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial Open
Background While growing evidence suggests the efficacy of various behavioral approaches to the preventive treatment of migraine, it remains largely unclear which behavioral interventions are indicated for which type of patient. This explo…
View article: Real-world effectiveness of fremanezumab in patients with migraine switching from another mAb targeting the CGRP pathway: a subgroup analysis of the Finesse Study
Real-world effectiveness of fremanezumab in patients with migraine switching from another mAb targeting the CGRP pathway: a subgroup analysis of the Finesse Study Open
Background Monoclonal antibodies targeting the CGRP pathway are effective and safe for prophylactic treatment of episodic (EM) and chronic migraine (CM). In case of treatment failure of a CGRP pathway targeting mAb, physician has to decide…
View article: What do patients’ efficacy and tolerability ratings of acute migraine medication tell us? Cross-sectional data from the DMKG Headache Registry
What do patients’ efficacy and tolerability ratings of acute migraine medication tell us? Cross-sectional data from the DMKG Headache Registry Open
Background Most migraine patients need an effective acute medication. Real-world data can provide important information on the performance of acute migraine medication in clinical practice. Methods We used data from the German Migraine and…
View article: Real-world treatment patterns and healthcare resource utilization among migraine patients: a German claims database analysis
Real-world treatment patterns and healthcare resource utilization among migraine patients: a German claims database analysis Open
Disease burden was high in patients receiving CGRP mAbs suggesting that patients treated preventively with CGRP mAbs shortly after product launch in Germany were severely affected, chronic migraine patients. The same may be true for patien…
View article: Attackenangst bei Migräne: Diagnostik und Behandlung
Attackenangst bei Migräne: Diagnostik und Behandlung Open
Zusammenfassung Im Kontext von Kopfschmerzerkrankungen beschreibt der Begriff „Attackenangst“ die Furcht vor dem Auftreten einer Kopfschmerzattacke. Ein Übermaß an Attackenangst kann sich ungünstig auf den Krankheitsverlauf bei Migräne aus…
View article: Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG)
Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG) Open
Backgound Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socioeconomic status (SES…
View article: Erratum zu: Konsensusstatement der Migräne- und Kopfschmerzgesellschaften (DMKG, ÖKSG & SKG) zur Therapiedauer der medikamentösen Migräneprophylaxe
Erratum zu: Konsensusstatement der Migräne- und Kopfschmerzgesellschaften (DMKG, ÖKSG & SKG) zur Therapiedauer der medikamentösen Migräneprophylaxe Open
View article: Erratum zu: Konsensusstatement der Migräne- und Kopfschmerzgesellschaften (DMKG, ÖKSG & SKG) zur Therapiedauer der medikamentösen Migräneprophylaxe
Erratum zu: Konsensusstatement der Migräne- und Kopfschmerzgesellschaften (DMKG, ÖKSG & SKG) zur Therapiedauer der medikamentösen Migräneprophylaxe Open
View article: Real-world treatment patterns and healthcare resource utilization among migraine patients: a German claims database analysis
Real-world treatment patterns and healthcare resource utilization among migraine patients: a German claims database analysis Open
Despite migraine being one of the most common neurological diseases, affected patients are often not effectively treated. This analysis describes the burden of migraine in Germany and assesses real-world treatment patterns and healthcare r…
View article: Real-world treatment patterns and healthcare resource utilization among migraine patients: A German claims database analysis
Real-world treatment patterns and healthcare resource utilization among migraine patients: A German claims database analysis Open
Despite migraine being one of the most common neurological diseases, affected patients are often not effectively treated. This analysis describes the burden of migraine in Germany and assesses real-world treatment patterns and healthcare r…
View article: Is prednisone still a reasonable option in the treatment of withdrawal headache in patients with chronic migraine and medication overuse headache in the age of <scp>CGRP</scp> antibodies? A narrative review
Is prednisone still a reasonable option in the treatment of withdrawal headache in patients with chronic migraine and medication overuse headache in the age of <span>CGRP</span> antibodies? A narrative review Open
Objective Along with the development of novel migraine therapies as the monoclonal antibodies against calcitonin gene‐related peptide (CGRP) and its receptor, the question arises if the treatment of chronic migraine (CM) and medication ove…
View article: Cluster-Kopfschmerz nach COVID-19-Impfung?
Cluster-Kopfschmerz nach COVID-19-Impfung? Open