Christopher A. Miller
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View article: Persistent binding of DNMT1 to chromatin causes replication dysfunction in TP53-mutated myeloid neoplasms
Persistent binding of DNMT1 to chromatin causes replication dysfunction in TP53-mutated myeloid neoplasms Open
Mutations in TP53 are the worst prognostic factor for myeloid malignancies, with a median survival of 6-9 months. Treatment with a hypomethylating agent (decitabine or azacitidine) is the standard of care for TP53-MNs, but responses are us…
View article: Mechanisms of chemotherapy resistance driven by Mecom overexpression
Mechanisms of chemotherapy resistance driven by Mecom overexpression Open
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that causes >11,000 deaths per year in the United States. Front-line therapy for young, medically fit patients involves intensive induction chemotherapy with an anthra…
View article: Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers
Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers Open
Whole-genome sequencing (WGS) is a comprehensive approach for the genomic evaluation of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). We recently described a streamlined tumor-only WGS assay (ChromoSeq) that uses Illumi…
View article: 5-006 Individualised NT-proBNP thresholds for the diagnosis of heart failure
5-006 Individualised NT-proBNP thresholds for the diagnosis of heart failure Open
View article: Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression
Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression Open
Mutations that initiate acute myeloid leukemia (AML) can cause clonal expansion without transformation (clonal hematopoiesis). Cooperating mutations, usually in signaling genes, are needed to cause overt disease, but these may require a sp…
View article: Prognostic impact of atrio-ventricular conduction abnormalities in non-ischemic cardiomyopathy
Prognostic impact of atrio-ventricular conduction abnormalities in non-ischemic cardiomyopathy Open
Background There is an urgent need to improve the risk-stratification for ventricular arrhythmias (VA) and sudden death (SD) in non-ischaemic cardiomyopathy (NICM), moving beyond left ventricular ejection fraction (LVEF). Late gadolinium e…
View article: pVACview: an interactive visualization tool for efficient neoantigen prioritization and selection
pVACview: an interactive visualization tool for efficient neoantigen prioritization and selection Open
Background Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these …
View article: Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis
Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis Open
Importance Development of myocardial fibrosis in patients with aortic stenosis precedes left ventricular decompensation and is associated with an adverse long-term prognosis. Objective To investigate whether early valve intervention reduce…
View article: Considerations for drug trials in hypertrophic cardiomyopathy
Considerations for drug trials in hypertrophic cardiomyopathy Open
Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden car…
View article: MOSAIC at the ELT: a unique instrument for the largest ground-based telescope
MOSAIC at the ELT: a unique instrument for the largest ground-based telescope Open
Pelló, Roser et al.-- Full list of authors: Pelló, Roser; Puech, Mathieu; Prieto, Éric; Rodrigues, Myriam; Sanchez-Janssen, Rubén.; Dalton, Gavin B.; Ducret, Franck; El Hadi, Kacem; García-Vargas, María. L.; Lynn, Jeff; Bharmal, Nazim A.; …
View article: PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells Open
The underlying mechanism(s) by which the PML::RARA fusion protein initiates acute promyelocytic leukemia is not yet clear. We defined the genomic binding sites of PML::RARA in primary mouse and human hematopoietic progenitor cells with V5-…
View article: Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes Open
Not available.
View article: Jugular venous flow dynamics during acute weightlessness
Jugular venous flow dynamics during acute weightlessness Open
The absence of hydrostatic pressure gradients in the vascular system and loss of tissue weight during weightlessness results in altered flow dynamics in the left internal jugular vein in some astronauts that may contribute to an increased …
View article: Rapid and accurate remethylation of DNA in <i>Dnmt3a-</i> deficient hematopoietic cells with restoration of DNMT3A activity
Rapid and accurate remethylation of DNA in <i>Dnmt3a-</i> deficient hematopoietic cells with restoration of DNMT3A activity Open
Here, we characterize the DNA methylation phenotypes of bone marrow cells from mice with hematopoietic deficiency of Dnmt3a or Dnmt3b (or both enzymes) or expressing the dominant-negative Dnmt3a R878H mutation [R882H in humans; the most co…
View article: Remote myocardial fibrosis predicts adverse outcome in patients with myocardial infarction on clinical cardiovascular magnetic resonance imaging
Remote myocardial fibrosis predicts adverse outcome in patients with myocardial infarction on clinical cardiovascular magnetic resonance imaging Open
Myocardial fibrosis, measured using CMR ECV, is a strong predictor of HHF and death in patients with evidence of MI. The mechanisms underlying remote myocardial fibrosis formation post-MI remain poorly understood, but factors other than in…
View article: Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB::MYH11 oncofusion protein
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB::MYH11 oncofusion protein Open
Several canonical translocations produce oncofusion genes that can initiate acute myeloid leukemia (AML). Although each translocation is associated with unique features, the mechanisms responsible remain unclear. While proteins interacting…
View article: FIGURE 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Mutations in AID motifs at SOCS1. A, Schematic of SOCS1 gene structure. Middle track shows where SOCS1 SNVs are located. Zoomed-in tracks (top and bottom) show the location of WRC/GYW motifs and the mutations that lie …
View article: Supplementary Figure 17 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 17 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Diagram of observed mutated components of the PI3K signaling cascade
View article: FIGURE 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
JAK/STAT signaling. A, Diagram of components of the JAK/STAT signaling cascade. Identified SMGs are shown in red; genes mutated in at least one non-hypermutated sample are shown in yellow; genes mutated only in the hypermutated samp…
View article: Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Observed COSMIC v.3 mutation signatures
View article: Supplementary Figure 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome Tumor VAF Distribution Partitioned by Validation Status
View article: Supplementary Figure 9 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 9 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Co-Occurrence and Mutual Exclusivity Among Significantly Mutated Genes
View article: FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Recurrently mutated genes in Hodgkin lymphoma. The frequency and type of mutations affecting genes mutated in 3 or more patients in our cohort are shown in each row. Genes determined to be significantly mutated using MuSiC and/or dN/dScv (…
View article: Supplementary Figure 8 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 8 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Comparison of Genes Shown to be Recurrently Mutated in Studies of Adult cHL
View article: FIGURE 6 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 6 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Regulating Hippo. A, Diagram of pathways that regulate Hippo signaling. Identified SMGs are shown in red; genes mutated in at least one non-hypermutated sample are shown in yellow; genes only mutated in the hypermutated sample (HL-5…
View article: Supplementary Figure 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome VAF and Depth of Coverage
View article: Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome Tumor VAF Distribution and Exome Tumor Coverage Partitioned by Validation Status
View article: Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Observed COSMIC v.3 mutation signatures
View article: Supplementary Figure 15 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 15 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
VAF Distribution of JAK/STAT and Hippo/TAZ/YAP regulation associated variants
View article: Supplementary Data File 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Data File 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Haloplex amplicons