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View article: 55 Tracking Cognitive Change in Huntington’s Disease with the Mini Mental State Exam and the Montreal Cognitive Assessment
55 Tracking Cognitive Change in Huntington’s Disease with the Mini Mental State Exam and the Montreal Cognitive Assessment Open
Objective: To assess the utility of the Mini Mental State Exam (MMSE) and Montreal Cognitive Assessment (MoCA) for tracking cognitive changes Huntington’s Disease. Participants and Methods: Currently, the most frequently used brief assessm…
View article: 59 Preliminary Findings of Semantic Interference in Learning and Memory Processes in Manifest Huntington’s Disease
59 Preliminary Findings of Semantic Interference in Learning and Memory Processes in Manifest Huntington’s Disease Open
Objective: To explore the usefulness of the Lowenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) [Crocco et al, 2013], a novel memory-based cognitive stress test capitalizing on semantic interference, in Huntington’s …
View article: Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease Open
Background Individuals with Huntington's disease (HD) experience motoric, cognitive, and psychiatric dysfunction. These difficulties can cause maladaptive behaviors that can be very distressing to family and caregivers. Capturing these beh…
View article: Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s Disease
Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s Disease Open
Introduction Measuring Huntingtin (Htt) protein in peripheral cells represents an essential step in biomarker discovery for Huntington’s Disease (HD), however to date, investigations into the salivary expression of Htt has been lacking. Me…
View article: Plasma neurofilament light in Huntington's disease: A marker for disease onset, but not symptom progression
Plasma neurofilament light in Huntington's disease: A marker for disease onset, but not symptom progression Open
These findings implicate plasma NfL as a peripheral prognostic marker for premanifest-HD. Notably, we show that significant correlations between NfL and clinical symptoms are detected only when PM + HD subjects are combined, but not within…
View article: Central Cognitive Processing Speed Is an Early Marker of Huntington's Disease Onset
Central Cognitive Processing Speed Is an Early Marker of Huntington's Disease Onset Open
Background Several studies have suggested that cognitive processing speed may be useful for assessing early cognitive change in premanifest Huntington's disease (HD); however, current measures lack the ability to control for the effects of…
View article: Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington’s Disease Patients and Healthy Control Subjects
Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington’s Disease Patients and Healthy Control Subjects Open
Growing evidence suggests that inflammatory responses, in both the brain and peripheral tissues, contribute to disease pathology in Huntington’s disease (HD), an inherited, progressive neurodegenerative disorder typically affecting adults …
View article: Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients
Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients Open
Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated …
View article: Handwriting Movement Abnormalities in Symptomatic and Premanifest Huntington's Disease
Handwriting Movement Abnormalities in Symptomatic and Premanifest Huntington's Disease Open
Background Kinematic measures of handwriting movements are sensitive to mild subclinical motor abnormalities stemming from a wide range of disorders involving the basal ganglia including Huntington's disease (HD). Prior research has not in…