Che Martin
YOU?
Author Swipe
View article: Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans
Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accumulated genomic mutations at an approximately linear rate since it first infected human populations in late 2019. Controversies remain regarding the identity, proportion,…
View article: Somatic Mutations in Renal Cyst Epithelium in Autosomal Dominant Polycystic Kidney Disease
Somatic Mutations in Renal Cyst Epithelium in Autosomal Dominant Polycystic Kidney Disease Open
Background Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy caused by mutations in PKD1 and PKD2 that is characterized by renal tubular epithelial cell proliferation and progressive CKD. Although the molecular mechanism…
View article: Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology
Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology Open
Background The recent outbreak of Ebola has been cited as the largest in history. Despite this global health crisis, few drugs are available to efficiently treat Ebola infections. Drug repurposing provides a potentially efficient solution …
View article: Erratum for Martin et al., Phylogenomic Identification of Regulatory Sequences in Bacteria: an Analysis of Statistical Power and an Application to Borrelia burgdorferi <i>Sensu Lato</i>
Erratum for Martin et al., Phylogenomic Identification of Regulatory Sequences in Bacteria: an Analysis of Statistical Power and an Application to Borrelia burgdorferi <i>Sensu Lato</i> Open
Volume 6, no. 2, doi: [10.1128/mBio.00011-15][1], 2015. The middle initial of the first author was incorrect. The byline should appear as shown above.
[1]: /lookup/doi/10.1128/mBio.00011-15
View article: Phylogenomic Identification of Regulatory Sequences in Bacteria: an Analysis of Statistical Power and an Application to Borrelia burgdorferi <i>Sensu Lato</i>
Phylogenomic Identification of Regulatory Sequences in Bacteria: an Analysis of Statistical Power and an Application to Borrelia burgdorferi <i>Sensu Lato</i> Open
Phylogenomic footprinting is an approach for ab initio identification of genome-wide regulatory elements in bacterial species based on sequence conservation. The statistical power of the phylogenomic approach depends on the degree of seque…
View article: Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4
Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4 Open
Significance Mutant p53 (mtp53) is a driver oncogene of breast cancer. Here, for the first time, to our knowledge, using an inducible endogenous knockdown system, we explore the mtp53 driven proteome. We report this key data set that highl…