Chelin Hu
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View article: Pure Vision Language Action (VLA) Models: A Comprehensive Survey
Pure Vision Language Action (VLA) Models: A Comprehensive Survey Open
The emergence of Vision Language Action (VLA) models marks a paradigm shift from traditional policy-based control to generalized robotics, reframing Vision Language Models (VLMs) from passive sequence generators into active agents for mani…
View article: 16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves
16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves Open
Introduction Diarrhea is a prevalent disease among calves, which significantly hinders their growth and development, thereby impacting farm productivity and revenue. This study aimed to investigate the impact of diarrhea on calf growth. Me…
View article: Data from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy
Data from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy Open
Previous studies have shown that the DNA repair component Metnase (SETMAR) mediates resistance to DNA damaging cancer chemotherapy. Metnase has a nuclease domain that shares homology with the Transposase family. We therefore virtually scre…
View article: Supplementary Figures 1 - 4 from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy
Supplementary Figures 1 - 4 from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy Open
PDF file - 670K, Figure S1. The composite approach for in silico compound selection. Figure S2. Superposition of the 3D structures of Metnase (model, blue) and MOS-1 active sites (2F7T, orange). Figure S3. Comparison between two metnase st…
View article: Supplementary Figures 1 - 4 from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy
Supplementary Figures 1 - 4 from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy Open
PDF file - 670K, Figure S1. The composite approach for in silico compound selection. Figure S2. Superposition of the 3D structures of Metnase (model, blue) and MOS-1 active sites (2F7T, orange). Figure S3. Comparison between two metnase st…
View article: Data from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy
Data from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy Open
Previous studies have shown that the DNA repair component Metnase (SETMAR) mediates resistance to DNA damaging cancer chemotherapy. Metnase has a nuclease domain that shares homology with the Transposase family. We therefore virtually scre…
View article: The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells
The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells Open
The goal of this study is to examine bisphenol AF (BPAF)-induced multinucleation (MNC) in comparison with dibutyl phthalate (DBP), known to induce MNC in mouse gonocytes in vivo. We performed image-based single-cell high content analysis (…
View article: Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes
Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes Open
Human obesity has become a global health epidemic, with few safe and effective pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in women after menopause greatly increases the risk of obesity and me…
View article: Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced <i>Nfe2l1</i> expression
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced <i>Nfe2l1</i> expression Open
The goal of this study was to determine if subunit displacement and/or alterations in proteasome biosynthesis could explain the changes observed in the levels of constitutive proteasomes (c‐20S) and immunoproteasomes (i‐20S) in the spinal …
View article: Reduced expression of the ferroptosis inhibitor glutathione peroxidase‐4 in multiple sclerosis and experimental autoimmune encephalomyelitis
Reduced expression of the ferroptosis inhibitor glutathione peroxidase‐4 in multiple sclerosis and experimental autoimmune encephalomyelitis Open
Glutathione peroxidase 4 ( GP x4) is the only enzyme capable of reducing toxic lipid hydroperoxides in biological membranes to the corresponding alcohols using glutathione as the electron donor. GP x4 is the major inhibitor of ferroptosis,…
View article: Nrf2‐dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis
Nrf2‐dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis Open
This study investigates the possible mechanism(s) underlying glutathione ( GSH ) deficiency in the mouse spinal cord during the course of myelin oligodendrocyte glycoprotein 35–55 peptide‐induced experimental autoimmune encephalomyelitis (…