Chelsea M. Black
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View article: Developmental and behavioral phenotypes of pediatric patients with <scp><i>PTEN</i></scp> hamartoma tumor syndrome
Developmental and behavioral phenotypes of pediatric patients with <span><i>PTEN</i></span> hamartoma tumor syndrome Open
Our study characterized the neurodevelopmental spectrum of individuals with PTEN Hamartoma Tumor Syndrome (PHTS), a syndrome that predisposes to both neurodevelopmental phenotypes and cancer risk. We aim to better understand life‐impacting…
View article: Resilience in the Depths: First Example of Fin Regeneration in a Silky Shark (Carcharhinus falciformis) following Traumatic Injury
Resilience in the Depths: First Example of Fin Regeneration in a Silky Shark (Carcharhinus falciformis) following Traumatic Injury Open
Tissue regeneration and wound healing remain extremely understudied in elasmobranchs as many wounds are recorded through one-off opportunistic observations with an inability for long-term monitoring of individuals. This study demonstrates …
View article: Supplementary Figure Legends from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure Legends from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 84K
View article: Supplementary Figure 4 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 4 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 71K, Percent of adoptively transferred low avidity T cells present in the mice compared between untreated mice and mice treated with Cy+vaccine and Cy+vaccine+OX40.
View article: Supplementary Figure 4 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 4 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 71K, Percent of adoptively transferred low avidity T cells present in the mice compared between untreated mice and mice treated with Cy+vaccine and Cy+vaccine+OX40.
View article: Supplementary Figure 1 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 1 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 202K, Microarray data determining differences in gene expression between high and low avidity T cells.
View article: Data from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Data from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
A major barrier to vaccines in cancer treatment is their failure to activate and maintain a complete cancer-specific CD8+ effector T-cell repertoire. Low-avidity T cells are more likely to escape clonal deletion in the thymus when compared…
View article: Supplementary Figure 3 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 3 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 134K, Demonstration of the ability of alphaOX40 and alpha41BB agonists to temporarily eliminate established tumors.
View article: Supplementary Figure Legends from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure Legends from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 84K
View article: Supplementary Figure 1 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 1 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 202K, Microarray data determining differences in gene expression between high and low avidity T cells.
View article: Supplementary Figure 2 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 2 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 99K, Protein expression of DR5, FasL, and CD24 compared between naive low avidity T cells, low avidity T cell activated in vivo, and low avidity T cells activated in vitro.
View article: Supplementary Figure 3 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 3 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 134K, Demonstration of the ability of alphaOX40 and alpha41BB agonists to temporarily eliminate established tumors.
View article: Supplementary Figure 2 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Supplementary Figure 2 from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
PDF file - 99K, Protein expression of DR5, FasL, and CD24 compared between naive low avidity T cells, low avidity T cell activated in vivo, and low avidity T cells activated in vitro.
View article: Data from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice
Data from Apoptosis-Regulated Low-Avidity Cancer-Specific CD8<sup>+</sup> T Cells Can Be Rescued to Eliminate HER2/neu–Expressing Tumors by Costimulatory Agonists in Tolerized Mice Open
A major barrier to vaccines in cancer treatment is their failure to activate and maintain a complete cancer-specific CD8+ effector T-cell repertoire. Low-avidity T cells are more likely to escape clonal deletion in the thymus when compared…
View article: Bacterial Communities in Multiple Tissues Across the Body Surface of Three Coastal Shark Species.
Bacterial Communities in Multiple Tissues Across the Body Surface of Three Coastal Shark Species. Open
Bacteria are known to have explicit roles within the microbiomes of host tissues, therefore examining these communities may prove useful in assessing host health and responses to environmental change. The present study contributes to the e…
View article: MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential Open
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the functi…
View article: Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy Open
Antibodies that target cell-surface molecules on T cells can enhance anti-tumor immune responses, resulting in sustained immune-mediated control of cancer. We set out to find new cancer immunotherapy targets by phenotypic screening on huma…