Chemin Lin
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View article: USING MULTI-SCALE ENTROPY ANALYSIS IN FMRI DATA TO EXAMINE THE COGNITIVE FUNCTION IN PATIENTS OF LATE-LIFE DEPRESSION AFTER ONE-YEAR FISH OIL SUPPLEMENT
USING MULTI-SCALE ENTROPY ANALYSIS IN FMRI DATA TO EXAMINE THE COGNITIVE FUNCTION IN PATIENTS OF LATE-LIFE DEPRESSION AFTER ONE-YEAR FISH OIL SUPPLEMENT Open
Background Late-life depression (LLD) is a risk factor for dementia and cognitive decline. Fish oil supplement is efficacious for depressive symptoms with cognitive protective benefits. While there is limited strategy to deter cognitive de…
View article: Classification of internet addiction using machine learning on electroencephalography synchronization and functional connectivity
Classification of internet addiction using machine learning on electroencephalography synchronization and functional connectivity Open
Background Internet addiction (IA) refers to excessive internet use that causes cognitive impairment or distress. Understanding the neurophysiological mechanisms underpinning IA is crucial for enabling an accurate diagnosis and informing t…
View article: Differential neuropsychiatric associations of plasma biomarkers in older adults with major depression and subjective cognitive decline
Differential neuropsychiatric associations of plasma biomarkers in older adults with major depression and subjective cognitive decline Open
Older adults with major depressive disorder (MDD) or early cognitive decline during the subjective cognitive decline (SCD) stage may exhibit neuropsychiatric symptoms such as anxiety, depression, and subtle cognitive impairment. The clinic…
View article: Life After Traumatic Brain Injury: Effects on the Lifestyle and Quality of Life of Community-Dwelling Patients
Life After Traumatic Brain Injury: Effects on the Lifestyle and Quality of Life of Community-Dwelling Patients Open
Persons who have experienced traumatic brain injury (TBI) may encounter a range of changes in their physical, mental, and cognitive functions as well as high fatigue levels. To gain a comprehensive understanding of the challenges faced by …
View article: User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability Study
User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability Study Open
Background To safeguard the most vulnerable individuals during the COVID-19 pandemic, numerous governments enforced measures such as stay-at-home orders, social distancing, and self-isolation. These social restrictions had a particularly n…
View article: Predicting suicidality in late‐life depression by 3D convolutional neural network and cross‐sample entropy analysis of resting‐state fMRI
Predicting suicidality in late‐life depression by 3D convolutional neural network and cross‐sample entropy analysis of resting‐state fMRI Open
Background : Predicting suicide is a pressing issue among older adults; however, predicting its risk is difficult. Capitalizing on the recent development of machine learning, considerable progress has been made in predicting complex behavi…
View article: Serotonin Syndrome From the Complex Drug Interactions of Second-Generation Antipsychotics in Older Patients: Case Report and Literature Review
Serotonin Syndrome From the Complex Drug Interactions of Second-Generation Antipsychotics in Older Patients: Case Report and Literature Review Open
To the Editor: Serotonin syndrome is a state caused by an excess of serotonergic activity in the nervous system that may occur with the use of serotonergic medications. Symptoms vary widely, ranging from mild to severe, and from altered me…
View article: P23: Suicide Prediction in late-life depression by Machine learning and Complexity analysis in resting-state functional MRI data
P23: Suicide Prediction in late-life depression by Machine learning and Complexity analysis in resting-state functional MRI data Open
Objective: Late-life suicide is the most serious consequences of late-life depression (LLD). Nevertheless, suicidal behavior is complex and hard to predict. With the help of MRI scans and machine learning algorithm, we aim to examine the n…
View article: Potential Mobile Health Applications for Improving the Mental Health of the Elderly: A Systematic Review
Potential Mobile Health Applications for Improving the Mental Health of the Elderly: A Systematic Review Open
The rapid aging of the global population presents challenges in providing mental health care resources for older adults aged 65 and above. The COVID-19 pandemic has further exacerbated the global population's psychological distress due to …
View article: User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability Study (Preprint)
User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability Study (Preprint) Open
BACKGROUND To safeguard the most vulnerable individuals during the COVID-19 pandemic, numerous governments enforced measures such as stay-at-home orders, social distancing, and self-isolation. These social restrictions had a particularly …
View article: Multimodal brain connectome-based prediction of suicide risk in people with late-life depression
Multimodal brain connectome-based prediction of suicide risk in people with late-life depression Open
Suicidal ideation, plans and behavior are particularly serious health issues among the older population, resulting in a higher likelihood of deaths than in any other age group. The increasing prevalence of depression in late life reflects …
View article: Review of EEG-based neurofeedback as a therapeutic intervention to treat depression
Review of EEG-based neurofeedback as a therapeutic intervention to treat depression Open
Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, and its prevalence has increased during the lockdowns implemented to curb the COVID-19 pandemic. There is …
View article: Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI
Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI Open
Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach, cross-sample entropy (CSE) analysis shows the nonlinear property in fMRI signals between b…
View article: Classification of Major Depressive Disorder using Machine Learning on brain structure and functional connectivity
Classification of Major Depressive Disorder using Machine Learning on brain structure and functional connectivity Open
Background: Timely identification of the risk of having Major Depressive Disorder (MDD) using the advanced machine learning (ML) approach has been popularized to generate neural indicators of MDD. However, past ML studies have usually empl…
View article: Sex Differences in the Relationship between Excessive Alcohol Consumption and Metabolic Abnormalities: A Community-Based Study in Taiwan
Sex Differences in the Relationship between Excessive Alcohol Consumption and Metabolic Abnormalities: A Community-Based Study in Taiwan Open
Excessive alcohol consumption, as part of an unhealthy lifestyle, can contribute to metabolic abnormalities. This study investigated the sex differences in the relationship between excessive drinking and the risk of metabolic abnormalities…
View article: Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline
Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline Open
Background Subjective cognitive decline (SCD) appears in the preclinical stage of the Alzheimer's disease continuum. In this stage, dynamic features are more sensitive than static features to reflect early subtle changes in functional brai…
View article: Meta-analytic evidence for the cognitive control model of loneliness in emotion processing
Meta-analytic evidence for the cognitive control model of loneliness in emotion processing Open
Loneliness is strongly related to affective dysregulation. However, the neuropsychological mechanisms underpinning the loneliness-affective processing relationships remain unclear. Here, we first utilised the coordinate-based activation li…
View article: Normative Data of Mini-Mental State Examination, Montreal Cognitive Assessment, and Alzheimer’s Disease Assessment Scale-Cognitive Subscale of Community-Dwelling Older Adults in Taiwan
Normative Data of Mini-Mental State Examination, Montreal Cognitive Assessment, and Alzheimer’s Disease Assessment Scale-Cognitive Subscale of Community-Dwelling Older Adults in Taiwan Open
Introduction: Appropriate tools and references are essential for evaluating individuals’ cognitive levels. This study validated the Taiwan version of the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-cog) and provided norma…
View article: Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset
Resting-State EEG Signal for Major Depressive Disorder Detection: A Systematic Validation on a Large and Diverse Dataset Open
Major depressive disorder (MDD) is a global healthcare issue and one of the leading causes of disability. Machine learning combined with non-invasive electroencephalography (EEG) has recently been shown to have the potential to diagnose MD…
View article: Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression
Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression Open
Gray matter reductions in the default mode network and lateral prefrontal regions and the ventrolateral prefrontal cortex-caudate connectivity alterations characterized suicidal thoughts and actions in patients with late-life depression.
View article: Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma
Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma Open
This study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tr…
View article: White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline
White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline Open
Objective: Although previous studies postulated that physical and cognitive decline codeveloped in preclinical dementia, the interconnected relationship among subjective cognitive complaints (SCCs), objective cognitive performance, and phy…
View article: Validation of the Traditional Chinese Version of the Pittsburgh Fatigability Scale for Older Adults
Validation of the Traditional Chinese Version of the Pittsburgh Fatigability Scale for Older Adults Open
Our results indicate that the TC-PFS is a valid instrument to measure perceived physical and mental fatigability in older Taiwanese adults.Clinical implications: Perceived fatigability reflects the underlying physical, mental or cognitive …
View article: Taiwanese Depression Questionnaire and AD8 Questionnaire for Screening Late-Life Depression in Communities
Taiwanese Depression Questionnaire and AD8 Questionnaire for Screening Late-Life Depression in Communities Open
The self-reported response to the TDQ is a feasible approach of identifying MDD in community-dwelling people. Combining TDQ and AD8 scores further improved depression detection in elderly people.
View article: 348 - Increased White Matter Hyperintensity and Brain Resting-state fMRI Topology Changes in Suicide Attempters of Late-life Depression
348 - Increased White Matter Hyperintensity and Brain Resting-state fMRI Topology Changes in Suicide Attempters of Late-life Depression Open
Supported by (1) medical research grants CMRPG3C0041/42 from Chang Gung Memorial Hospital and NRRPG2H0031 from Ministry of Science and Technology, Taiwan to Chemin Lin (2) NMRPG3G6031/32 from Ministry of Science and Technology, Taiwan to S…