Aimin Chen
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Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort Open
We used a regression calibration method to leverage robust, repeated lead exposure data in our prospective pregnancy and birth cohort. In this cohort with low levels of lead exposure, cumulative childhood lead exposure estimate was negativ…
View article: Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies Open
Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these chemicals diff…
View article: Associations of endocrine disrupting chemical biomarkers and their mixture with vitamin D biomarker concentrations in childhood: The HOME Study
Associations of endocrine disrupting chemical biomarkers and their mixture with vitamin D biomarker concentrations in childhood: The HOME Study Open
Findings suggest that EDCs may alter the childhood vitamin D system. Associations with higher vitamin D biomarker levels may indicate competitive receptor binding and altered cellular transport with potential adverse downstream health impa…
View article: Prenatal exposure to phthalates and preschool children’s intellectual scores: Effect modification by child sex
Prenatal exposure to phthalates and preschool children’s intellectual scores: Effect modification by child sex Open
Findings from this pan-Canadian cohort provide some evidence that gestational ΣDiDPm is adversely associated with child cognition, with sex-specific vulnerabilities. The positive associations with MMP and MBzP warrant further research.
Associations of prenatal per- and polyfluoroalkyl substances with whole blood folate levels in pregnant women in the Health Outcomes and Measures of the Environment (HOME) Study Open
Background: Folate plays a critical role during pregnancy, preventing neural tube defects and possibly adverse neurodevelopment. Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that may decrease folate levels. Although s…
View article: Association between gestational environmental chemical mixtures and folate exposures with autistic behaviors in a Canadian birth cohort
Association between gestational environmental chemical mixtures and folate exposures with autistic behaviors in a Canadian birth cohort Open
Background: Prenatal exposure to environmental chemicals may be associated with autism or autistic-like behaviors. Previous studies suggest that these associations are stronger when folic acid (FA) supplementation is lower. Methods: We use…
View article: Associations of gestational and childhood urinary triclosan concentrations with atopic and allergic symptoms in Health Outcomes and Measures of the Environment (HOME) Study participants ages 1–12 years
Associations of gestational and childhood urinary triclosan concentrations with atopic and allergic symptoms in Health Outcomes and Measures of the Environment (HOME) Study participants ages 1–12 years Open
Childhood urinary triclosan concentrations were associated with caregiver reported eczema, and more weakly with allergic rhinitis. Associations of gestational triclosan with allergic outcomes differed by child sex, suggesting heightened su…
P-098 Impact of low-lactate culture medium on embryo development and euploidy rates in sibling oocytes Open
Study question Does low-lactate culture medium have any effects on embryo development and the euploidy rates of blastocysts? Summary answer Low-lactate culture medium appears to accelerate embryo development, resulting in a higher yield of…
View article: Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta Open
The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environmen…
View article: Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study
Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study Open
Our study suggests that adolescence is a unique window for gut microbial composition and that it may be shaped by both early-life and concurrent exposures, highlighting its potential in future epidemiologic research.
View article: Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies
Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies Open
Background Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these che…
View article: Associations of Urban Blue and Green Spaces With Coronary Artery Calcification in Black Individuals and Disadvantaged Neighborhoods
Associations of Urban Blue and Green Spaces With Coronary Artery Calcification in Black Individuals and Disadvantaged Neighborhoods Open
BACKGROUND: Proximity to urban blue and green spaces has been associated with improved cardiovascular health; however, few studies have examined the role of race and socioeconomic status in these associations. METHODS: Data were from the C…
View article: Prenatal and Childhood Phthalate Mixtures and Adolescent Sleep Health in the HOME Study
Prenatal and Childhood Phthalate Mixtures and Adolescent Sleep Health in the HOME Study Open
Phthalate metabolite concentrations during pregnancy and childhood were associated with poorer adolescent sleep health. https://doi.org/10.1289/EHP15221.
View article: Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns Open
Background Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways r…
Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015–2016 Open
Background: Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological studies have explored these effects. Methods: National Health and Nutrition Examination Survey (NHANES) 2015–2016 …
View article: Personal care product use and per- and polyfluoroalkyl substances in pregnant and lactating people in the Maternal-Infant Research on Environmental Chemicals study
Personal care product use and per- and polyfluoroalkyl substances in pregnant and lactating people in the Maternal-Infant Research on Environmental Chemicals study Open
Our results show that PCP use may be a modifiable source of PFAS exposure in pregnant and lactating populations. These results along with growing scientific evidence can help inform PFAS regulation and guide individual choices to reduce PF…
Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents’ eating behaviors Open
Per- and polyfluoroalkyl substances (PFAS), persistent environmental chemicals, may act as obesogens by interacting with neuroendocrine pathways regulating energy homeostasis and satiety signals influencing adolescent eating behaviors. In …