Jack Chen
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View article: Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow
Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow Open
SUMMARY During mouse development, hematopoietic stem and progenitor cells (HSPC) originate from hemogenic endothelial cells (ECs) through a process of endothelial-to-hematopoietic transition. These HSPC are thought to fully sustain adult h…
View article: The Intersection of <scp>HIV</scp> and Migration: Conceptualising Quality of Life Among Asian‐Born Men Who Have Sex With Men Living With <scp>HIV</scp> in Australia
The Intersection of <span>HIV</span> and Migration: Conceptualising Quality of Life Among Asian‐Born Men Who Have Sex With Men Living With <span>HIV</span> in Australia Open
This qualitative study aimed to understand how migration experiences shape wellbeing and quality of life (QoL) for Asian‐born men who have sex with men (MSM) who are living with HIV in Australia, and to identify relevant support needs. Dra…
View article: Improving detection of carcinoma <i>in situ</i> in bladder cancer: urinary cytology vs the Xpert® <scp>BC</scp> Monitor
Improving detection of carcinoma <i>in situ</i> in bladder cancer: urinary cytology vs the Xpert® <span>BC</span> Monitor Open
Objective To investigate and compare the performance of urinary cytology and the Xpert BC Monitor test in the detection of bladder cancer in various clinically significant patient cohorts, including patients with carcinoma in situ (CIS), i…
View article: Potential of an mRNA-Based Urine Assay (Xpert<sup>®</sup> Bladder Cancer Detection<sup>1</sup>) in Hematuria Patients - Results from a Cohort Study
Potential of an mRNA-Based Urine Assay (Xpert<sup>®</sup> Bladder Cancer Detection<sup>1</sup>) in Hematuria Patients - Results from a Cohort Study Open
BACKGROUND AND OBJECTIVE: Assessment of patients with hematuria (aH) remains a challenge in urological practice, balancing the benefits of diagnosing a potentially underlying bladder cancer (UCa) against the risks of possibly unnecessary d…
View article: Review 2: "SARS-CoV-2 ORF8 Modulates Lung Inflammation and Clinical Disease Progression"
Review 2: "SARS-CoV-2 ORF8 Modulates Lung Inflammation and Clinical Disease Progression" Open
In this manuscript, McGrath, et al. studied the SARS-CoV-2 ORF8 gene on modulating clinical disease progression and concluded that SARS-CoV-2 lacking this ORF8 protein and virus possessing naturally occurring point mutations impacts pathog…
View article: Implementation and Evaluation of a 24/7 eICU (Enhanced ICU) Model of Care in Regional and Rural NSW ICUs
Implementation and Evaluation of a 24/7 eICU (Enhanced ICU) Model of Care in Regional and Rural NSW ICUs Open
Background The global COVID 19 pandemic was associated with an increased demand for respiratory support in Intensive Care Units (ICU) and measures were put in place in all jurisdictions to enhance ICU bed capacity. In NSW, a need was ident…
View article: Cost-effective Mobile Solution for Autonomous and Continuous Vital Signs Monitoring
Cost-effective Mobile Solution for Autonomous and Continuous Vital Signs Monitoring Open
The Covid-19 Pandemic has renewed interest in contactless vital signs monitoring using state-of-the-art computer vision, which can efficiently screen for symptoms while reducing the risk of disease transmission. Despite the promising perfo…
View article: Cost-effective Mobile Solution for Autonomous and Continuous Vital Signs Monitoring
Cost-effective Mobile Solution for Autonomous and Continuous Vital Signs Monitoring Open
The Covid-19 Pandemic has renewed interest in contactless vital signs monitoring using state-of-the-art computer vision, which can efficiently screen for symptoms while reducing the risk of disease transmission. Despite the promising perfo…
View article: Acceptance of a computer vision facilitated protocol to measure adherence to face mask use: a single-site, observational cohort study among hospital staff
Acceptance of a computer vision facilitated protocol to measure adherence to face mask use: a single-site, observational cohort study among hospital staff Open
Objectives Mask adherence continues to be a critical public health measure to prevent transmission of aerosol pathogens, such as SARS-CoV-2. We aimed to develop and deploy a computer vision algorithm to provide real-time feedback of mask w…
View article: Impact of a standardised rapid response system on clinical outcomes of female patients: an interrupted time series approach
Impact of a standardised rapid response system on clinical outcomes of female patients: an interrupted time series approach Open
Background This study aimed to assess the impact of a standardised rapid response systems (the Between the Flags (BTF)) implemented across New South Wales (NSW), Australia, among female patients. Methods We conducted an interrupted time se…
View article: Navigating the Complex Web of Prescribing Amyloidosis Therapeutics: A Primer
Navigating the Complex Web of Prescribing Amyloidosis Therapeutics: A Primer Open
Advancement in the diagnosis and treatment of transthyretin amyloid cardiomyopathy has made great strides in recent years. Novel therapeutics for transthyretin amyloidosis such as tafamidis, patisiran, and inotersen have shown significant …
View article: Cultivating “Webside Manner” at the UME-GME Transition Point During the COVID-19 Pandemic: A Novel Virtual Telemedicine Curriculum
Cultivating “Webside Manner” at the UME-GME Transition Point During the COVID-19 Pandemic: A Novel Virtual Telemedicine Curriculum Open
BACKGROUND Telemedicine use in the US has continued to grow over the past few years with the development of new technology and in response to the COVID-19 pandemic. This has led to a growing need for formal training in telemedicine for cli…
View article: Bolt: Bridging the Gap between Auto-tuners and Hardware-native Performance
Bolt: Bridging the Gap between Auto-tuners and Hardware-native Performance Open
Today's auto-tuners (e.g., AutoTVM, Ansor) generate efficient tensor programs by navigating a large search space to identify effective implementations, but they do so with opaque hardware details. Thus, their performance could fall behind …
View article: Impact of an acute geriatric outreach service to residential aged care facilities on hospital admissions
Impact of an acute geriatric outreach service to residential aged care facilities on hospital admissions Open
Introduction Residential aged care facility (RACF) residents frequently present to the emergency department (ED) and are often admitted to hospital. Some presentations and admissions may be avoidable. In 2013, Bankstown‐Lidcombe Hospital i…
View article: Genome Sequence, Transcriptome, and Annotation of Rodent Malaria Parasite Plasmodium Yoelii Nigeriensis N67
Genome Sequence, Transcriptome, and Annotation of Rodent Malaria Parasite Plasmodium Yoelii Nigeriensis N67 Open
Background : Rodent malaria parasites are important models for studying host-malaria parasite interactions such as host immune response, mechanisms of parasite evasion of host killing, and vaccine development. One of the rodent malaria par…
View article: Mask-wearing and control of SARS-CoV-2 transmission in the USA: a cross-sectional study
Mask-wearing and control of SARS-CoV-2 transmission in the USA: a cross-sectional study Open
Flu Lab, Google.org (via the Tides Foundation), National Institutes for Health, National Science Foundation, Morris-Singer Foundation, MOOD, Branco Weiss Fellowship, Ending Pandemics, Centers for Disease Control and Prevention (USA).
View article: Additional file 1 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67
Additional file 1 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67 Open
Additional file 1: Figure S1. Strategies of genome assembly and annotation, and plot of contig length distributions of the Plasmodium y. yoelii N67 parasite genome assembly. a, Diagram illustrating the processes of aligning N67 CCS reads (…
View article: Additional file 12 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67
Additional file 12 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67 Open
Additional file 12: Table S11. Single nucleotide substitutions and indels between Plasmodium y. nigeriensis N67 (ALT) and P. y. yoelii 17XNL (REF) or P. y. yoelii YM parasites with predicted medium and high functional impacts.
View article: Additional file 3 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67
Additional file 3 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67 Open
Additional file 3: Table S2. Predicted gene and protein sequences from Plasmodium y. nigeriensis N67 parasite genome and transcriptome.
View article: Additional file 6 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67
Additional file 6 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67 Open
Additional file 6: Table S5. Lists of Plasmodium y. nigeriensis N67 genes clustered into selected Reactome pathways.
View article: Additional file 4 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67
Additional file 4 of Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67 Open
Additional file 4: Table S3. Predicted proteins of Plasmodium y. nigeriensis N67 matching IntrPro domains.