Heyan Chen
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View article: A population-based analysis of a risk stratification system for predicting radiotherapy benefits in invasive breast carcinoma of no special type with medullary pattern
A population-based analysis of a risk stratification system for predicting radiotherapy benefits in invasive breast carcinoma of no special type with medullary pattern Open
We developed and validated a prognostic nomogram for IBC-NST with medullary pattern that accurately stratifies patients by risk. Our findings indicate that radiotherapy is associated with a survival benefit primarily in low-risk patients, …
View article: Clinicopathological characteristics and survival outcomes in spindle cell carcinoma (SpCC) of the breast: A SEER population-based study
Clinicopathological characteristics and survival outcomes in spindle cell carcinoma (SpCC) of the breast: A SEER population-based study Open
Spindle cell carcinoma (SpCC) of the breast is a rare entity. The aim of this study was to provide more information for understanding this disease and to improve the management of it in the clinic. Patients with SpCC and invasive ductal ca…
View article: A Population-Based Analysis of a Risk Stratification System for Predicting Radiotherapy Benefits in Medullary Breast Carcinoma
A Population-Based Analysis of a Risk Stratification System for Predicting Radiotherapy Benefits in Medullary Breast Carcinoma Open
Background Medullary breast carcinoma (MBC), a rare histological subtype representing 3-5% of breast malignancies, presents unique therapeutic challenges due to its distinct clinicopathological characteristics and uncertain radiotherapy (R…
View article: Clinicopathological features and risk factors for local recurrence of breast phyllodes tumors: a dual-center, 12-year, retrospective study
Clinicopathological features and risk factors for local recurrence of breast phyllodes tumors: a dual-center, 12-year, retrospective study Open
Purpose To clarify the risk factors of phyllodes tumor (PT) for local recurrence (LR). Methods Data from 829 patients with pathologically confirmed benign, borderline and malignant PT of the breast, diagnosed from between 2011 to 2023, wer…
View article: Correlation Analysis between Serum NLRP1 Inflammasome and Depression in Acute Stage of Stroke
Correlation Analysis between Serum NLRP1 Inflammasome and Depression in Acute Stage of Stroke Open
Introduction: The aim of this study was to investigate the correlation between serum NLRP1 inflammasome level and depressive state in acute stage of stroke. Methods: A total of 102 patients with acute stroke who were hospitalized for the f…
View article: Identification of Mitochondrial and Succinylation Modification-Related Gene Signature in Ischemic Stroke
Identification of Mitochondrial and Succinylation Modification-Related Gene Signature in Ischemic Stroke Open
Ischemic stroke (IS) is a leading cause of death and disability worldwide, often associated with immune dysregulation, mitochondrial dysfunction, and altered protein succinylation. This study aimed to identify mitochondrial and succinylati…
View article: Exploring the role of mitophagy-related genes in breast cancer: subtype classification and prognosis prediction
Exploring the role of mitophagy-related genes in breast cancer: subtype classification and prognosis prediction Open
Background: Breast cancer (BC) is the most common cancer among women globally and poses the leading health threat to women worldwide, with persistently high incidence rates. Mitophagy is a selective autophagy process that specifically targ…
View article: The nodal positivity rate in breast pCR patients with initially, clinically node-negative breast cancer after neoadjuvant systemic therapy: A systematic review and meta-analysis
The nodal positivity rate in breast pCR patients with initially, clinically node-negative breast cancer after neoadjuvant systemic therapy: A systematic review and meta-analysis Open
Background The axillary lymph node positive (ypN+) rate in patients with clinically node-negative (cN0) breast cancer who have achieved breast pathologic complete response (bpCR) after neoadjuvant systemic therapy (NST) is extremely low, a…
View article: Evaluation of outcome of chemotherapy for breast cancer patients older than 70 years: A SEER-based study
Evaluation of outcome of chemotherapy for breast cancer patients older than 70 years: A SEER-based study Open
Background With the aging of the population, the number of elderly breast cancer cases has increased. However, there is a lack of effective randomized clinical trial data to support whether elderly patients should receive chemotherapy. Our…
View article: Nomogram for predicting axillary upstaging in clinical node-negative breast cancer patients receiving neoadjuvant chemotherapy
Nomogram for predicting axillary upstaging in clinical node-negative breast cancer patients receiving neoadjuvant chemotherapy Open
Purpose The prediction of axillary lymph node status after neoadjuvant chemotherapy (NAC) becoming critical because of the advocation of the de-escalation of axillary management. We investigate associated factors of axillary upstaging in c…
View article: The outcome of neoadjuvant chemotherapy and the current trend of surgical treatment in young women with breast cancer: A multicenter real-world study (CSBrS-012)
The outcome of neoadjuvant chemotherapy and the current trend of surgical treatment in young women with breast cancer: A multicenter real-world study (CSBrS-012) Open
Background and objectives The relationship between age and the outcome of breast cancer neoadjuvant chemotherapy (NAC) remains controversial, and little is known about the choice of surgical treatment for young patients. In this multicente…
View article: Efficacy analysis of neoadjuvant chemotherapy with or without anthracyclines in female patients with HER2-positive breast cancer in China: a nationwide, multicenter, 10-year retrospective study (CSBrS-012)
Efficacy analysis of neoadjuvant chemotherapy with or without anthracyclines in female patients with HER2-positive breast cancer in China: a nationwide, multicenter, 10-year retrospective study (CSBrS-012) Open
Background: In the era of targeted therapy, whether patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer are exempted from anthracycline usage in the neoadjuvant setting is controversial. Objectives: Our obj…
View article: Elevated ADAM-like Decysin-1 (ADAMDEC1) expression is associated with increased chemo-sensitivity and improved prognosis in breast cancer patients
Elevated ADAM-like Decysin-1 (ADAMDEC1) expression is associated with increased chemo-sensitivity and improved prognosis in breast cancer patients Open
Elevated ADAMDEC1 expression is associated with increased chemosensitivity and better prognosis in breast cancer patients.
View article: A nomogram to identify appropriate candidates for breast-conserving surgery among young women with breast cancer: A large cohort study
A nomogram to identify appropriate candidates for breast-conserving surgery among young women with breast cancer: A large cohort study Open
Background There is a gradual increase of female breast cancer under 35 years old, who was characterized as poor prognosis. Whether young patients could obtain greater survival benefits from breast-conserving surgery (BCS) than mastectomy …
View article: A Novel Risk-Scoring System to Identify the Potential Population Benefiting From Adjuvant Chemotherapy for Node-Negative TNBC Patients With Tumor Size Less Than 1 cm
A Novel Risk-Scoring System to Identify the Potential Population Benefiting From Adjuvant Chemotherapy for Node-Negative TNBC Patients With Tumor Size Less Than 1 cm Open
Background and Objectives Whether chemotherapy is needed in node-negative triple-negative breast cancer (TNBC) patients with tumor size less than 1 cm is still controversial. In our research, we constructed a novel risk-scoring system to i…
View article: Evaluation of outcome of chemotherapy for breast cancer patients older than 70 years: A SEER-based study
Evaluation of outcome of chemotherapy for breast cancer patients older than 70 years: A SEER-based study Open
Background: With the aging of the population, the number of elderly breast cancer cases has increased. However, there is a lack of effective randomized clinical trial data to support whether elderly patients should receive chemotherapy. Ou…
View article: Effect of the Nipple-Excising Breast-Conserving Therapy in Female Breast Cancer: A Competing Risk Analysis and Propensity Score Matching Analysis of Results Based on the SEER Database
Effect of the Nipple-Excising Breast-Conserving Therapy in Female Breast Cancer: A Competing Risk Analysis and Propensity Score Matching Analysis of Results Based on the SEER Database Open
Introduction Due to the lack of randomized controlled trial, the effectiveness and oncological safety of nipple-excising breast-conserving therapy (NE-BCT) for female breast cancer (FBC) remains unclear. We aimed to explore and investigate…
View article: Protective effect of Rhus chinensis Mill. extract against liver cirrhosis in rats
Protective effect of Rhus chinensis Mill. extract against liver cirrhosis in rats Open
Purpose: To study the effect of Rhus chinensis Mill. extract (RCME) on diethylnitrosamine (DEN)-induced liver cirrhosis in rats.
Methods: RCME was obtained by extracting the dried Rhus chinensis Mill. in water. Liver cirrhosis rat…
View article: Bioinformatics analysis for the role of CALR in human cancers
Bioinformatics analysis for the role of CALR in human cancers Open
Cancer is one of the most important public health problems in the world. The curative effect of traditional surgery, radiotherapy and chemotherapy is limited and has inevitable side effects. As a potential target for tumor therapy, few stu…
View article: Research on Effectiveness of Prior Cancer on Survival Outcomes for Patients with Nonmetastatic Triple-Negative Breast Cancer: A Competing Risk Analysis and Propensity Score Matching Analysis of the SEER Database
Research on Effectiveness of Prior Cancer on Survival Outcomes for Patients with Nonmetastatic Triple-Negative Breast Cancer: A Competing Risk Analysis and Propensity Score Matching Analysis of the SEER Database Open
Introduction. Knowledge of the effect of prior cancer on long-term survival outcomes for patients with nonmetastatic triple-negative breast cancer (TNBC) remained unclear. The aim of this study was to explore and identify the effectiveness…
View article: A Comprehensive Pan-Cancer Analysis of RBM8A Based on Data Mining
A Comprehensive Pan-Cancer Analysis of RBM8A Based on Data Mining Open
Background. As a member of the exon junction complex (EJC), RNA-binding motif protein 8A (RBM8A) plays a crucial role in the maintenance of mRNA and multiple activities of an organism. Immunotherapy has been proven to be a staple type of c…
View article: A nomogram based on CENPP expression for survival prediction in breast cancer
A nomogram based on CENPP expression for survival prediction in breast cancer Open
Our study showed that CENPP was a novel prognostic factor for patients with BC, and the established nomogram could provide valuable information on prognostic prediction for patients with BC.
View article: Nomogram Predicts the Role of Contralateral Prophylactic Mastectomy in Male Patients With Unilateral Breast Cancer Based on SEER Database: A Competing Risk Analysis
Nomogram Predicts the Role of Contralateral Prophylactic Mastectomy in Male Patients With Unilateral Breast Cancer Based on SEER Database: A Competing Risk Analysis Open
Background Contralateral prophylactic mastectomy (CPM) in female breast cancer (FBC) is supported by multiple clinical studies and consensus guidelines, but knowledge of preventive contralateral mastectomy in male breast cancer (MaBC) is v…
View article: A systematic analysis of a potential metabolism-related prognostic signature for breast cancer patients
A systematic analysis of a potential metabolism-related prognostic signature for breast cancer patients Open
In summary, we systematically developed a potential metabolism-related gene risk model for predicting prognosis in breast cancer patients.
View article: Research on the Role of Combined Chemotherapy and Radiotherapy in Patients With N+ Non-Metastatic Metaplastic Breast Carcinoma: A Competing Risk Analysis Model Based on the SEER database, 2000 to 2015
Research on the Role of Combined Chemotherapy and Radiotherapy in Patients With N+ Non-Metastatic Metaplastic Breast Carcinoma: A Competing Risk Analysis Model Based on the SEER database, 2000 to 2015 Open
Purpose Due to the rarity of metaplastic breast carcinoma (MpBC), no randomized trials have investigated the role of combined chemotherapy and radiotherapy (CCRP) in this condition. We aimed to explore and identify the effectiveness of CCR…
View article: Nomogram-derived prediction of pathologic complete response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy (NCT)
Nomogram-derived prediction of pathologic complete response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy (NCT) Open
Background Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insufficient. Combining mult…