Jianmin Chen
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View article: Characterization of VOCs at Shaoxing in the Winter Campaign: Sources and Chemical Reactivity
Characterization of VOCs at Shaoxing in the Winter Campaign: Sources and Chemical Reactivity Open
Despite recent improvements in particulate matter (PM) pollution, haze events still frequently occur in many regions of China. Volatile organic compounds (VOCs), as key precursors in atmospheric photochemistry, play a crucial role in haze …
View article: Neutrophil extracellular traps released by CD177+ neutrophils aggravated inflammation and neuronal impairment post-SCI
Neutrophil extracellular traps released by CD177+ neutrophils aggravated inflammation and neuronal impairment post-SCI Open
Spinal cord injury (SCI) causes irreversible motor and sensory dysfunction. Initial mechanical injury breaches the blood-spinal cord barrier (BSCB), triggering a rapid influx of neutrophils. However, previous studies on neutrophils after S…
View article: Regulation of NAD+ Homeostasis by SsNrtR in Streptococcus Sobrinus: A Critical Determinant of Its Cariogenic Potential
Regulation of NAD+ Homeostasis by SsNrtR in Streptococcus Sobrinus: A Critical Determinant of Its Cariogenic Potential Open
Nicotinamide adenine dinucleotide (NAD+) serves as a critical cofactor in redox reactions and metabolic transformations catalyzed by NAD-dependent enzymes and is essential for bacterial survival and virulence. The biosynthesis of NAD+ in t…
View article: A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants
A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants Open
The detection of hepatitis B surface antigen (HBsAg) is fundamental for the diagnosis of chronic hepatitis B (CHB). However, current diagnostic assays that rely on antibodies targeting the conformational "a" determinant of HBsAg are freque…
View article: Online molecular insights into sources and formation of organic aerosol in Shanghai
Online molecular insights into sources and formation of organic aerosol in Shanghai Open
Organic aerosols (OA) constitute a large portion of atmospheric aerosols. The detailed sources of OA, especially precursors and formation processes of secondary OA (SOA) in megacities remain unclear, largely due to lack of molecular compos…
View article: Managing Rare Postoperative Complications in Cornual Heterotopic Pregnancy: Two Case Reports
Managing Rare Postoperative Complications in Cornual Heterotopic Pregnancy: Two Case Reports Open
Minimally invasive surgery is effective for CHP, but complications such as AVF and persistent ectopic tissue can arise and require timely reintervention. Transvaginal ultrasonography is essential for early detection. With multidisciplinary…
View article: ACLY regulates autolysosome acidification through tubulin acetylation‐mediated assembly of V‐ATPase subunits in Alzheimer's disease model mice
ACLY regulates autolysosome acidification through tubulin acetylation‐mediated assembly of V‐ATPase subunits in Alzheimer's disease model mice Open
INTRODUCTION Faulty autolysosome acidification leads to dystrophic neurites—an early event propelling Alzheimer's disease (AD) progression—yet the underlying mechanism remains elusive. METHODS To elucidate the physiological functions of ne…
View article: Sudy on the Extraction of High-Purity 226 Ra Solutions from Uranium Ore
Sudy on the Extraction of High-Purity 226 Ra Solutions from Uranium Ore Open
This study investigated the enrichment of radium ( 226 Ra) from uranium ore using hydrochloric acid. 226 Ra was leached from the ore and then isolated through barium sulphate co-precipitation. A subsequent thermal conversion transformed in…
View article: Toxic dust emission from drought-exposed lake beds – a new air pollution threat from dried lakes
Toxic dust emission from drought-exposed lake beds – a new air pollution threat from dried lakes Open
Many lakes worldwide are shrinking rapidly due to climate change and human activities. Pollutants accumulated in dried lake bed sediments may be released into the atmosphere as dust aerosols. However, whether lake bed dust carries sufficie…
View article: Atmospheric water cluster–catalyzed formation of nitroaromatics as a secondary aerosol source
Atmospheric water cluster–catalyzed formation of nitroaromatics as a secondary aerosol source Open
Nitroaromatic compounds (NACs) are an abundant class of compounds in atmospheric particulate matter, exerting considerable impacts on air quality, climate, and public health. They are typically derived from secondary formation, which is ge…
View article: Characteristics and Genetic Mechanism of Dolomite Reservoirs:the case study of the Third Member of the Feixianguan Formation in the Puguang Gas Field, Sichuan, China
Characteristics and Genetic Mechanism of Dolomite Reservoirs:the case study of the Third Member of the Feixianguan Formation in the Puguang Gas Field, Sichuan, China Open
This study focuses on the dolomite reservoirs of the Third Member of the Feixianguan Formation in the Puguang Gas Field. Based on outcrop, core, and thin-section observations, combined with cathodoluminescence, scanning electron microscopy…
View article: Increasing Contribution of Condensable Particulate Matter From Stationary Combustion Sources Under Strict Control Standards in China
Increasing Contribution of Condensable Particulate Matter From Stationary Combustion Sources Under Strict Control Standards in China Open
China's implementation of stringent emission control measures during 2014–2020 has effectively reduced filterable particulate matter (FPM) emissions from stationary combustion sources, while increasing the contribution of condensable parti…
View article: Pregnancy outcomes and recurrence following surgical treatment of cesarean scar pregnancy: a retrospective analysis
Pregnancy outcomes and recurrence following surgical treatment of cesarean scar pregnancy: a retrospective analysis Open
Background Cesarean scar pregnancy (CSP) is a high-risk ectopic pregnancy, and the influence of surgical treatments on subsequent fertility and pregnancy outcomes remains poorly understood. This study aimed to investigate the impact of dif…
View article: Chitosan scaffolds for bone applications: a detailed review of main types, features and multifaceted uses
Chitosan scaffolds for bone applications: a detailed review of main types, features and multifaceted uses Open
Chitosan scaffolds, derived from the exoskeletons of crustaceans, have become a foundational element in bone tissue engineering, celebrated for their exceptional biocompatibility, biodegradability, and inherent osteoconductive properties. …
View article: Advances in the Application of Graphene and Its Derivatives in Drug Delivery Systems
Advances in the Application of Graphene and Its Derivatives in Drug Delivery Systems Open
Graphene, owing to its exceptionally high specific surface area, abundant surface functional groups, and outstanding biocompatibility, exhibits tremendous potential in the development of nanodrug delivery systems. This review systematicall…
View article: Diverse Nitrogen‐Containing Organic Compounds in Cloud Water Formed via Nucleophilic Addition Reaction Between Carboxylic Acid and Ammonia
Diverse Nitrogen‐Containing Organic Compounds in Cloud Water Formed via Nucleophilic Addition Reaction Between Carboxylic Acid and Ammonia Open
Cloud droplets serve as a significant sink for atmospheric organic matter due to gas‐liquid transformations and interfacial reactions, containing abundant nitrogen‐containing organic compounds (NOCs). However, the formation mechanisms of N…
View article: Measurement of charged hadron multiplicity in Au+Au collisions at $$ \sqrt{{\textrm{s}}_{\textrm{NN}}} $$ = 200 GeV with the sPHENIX detector
Measurement of charged hadron multiplicity in Au+Au collisions at $$ \sqrt{{\textrm{s}}_{\textrm{NN}}} $$ = 200 GeV with the sPHENIX detector Open
A bstract The pseudorapidity distribution of charged hadrons produced in Au+Au collisions at a center-of-mass energy of $$ \sqrt{{\textrm{s}}_{\textrm{NN}}} $$ = 200 GeV is measured using data collected by the sPHENIX detector. Charge…
View article: Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial
Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial Open
We aimed to assess the tolerability and efficacy of finotonlimab (an anti-programmed cell death protein-1 antibody) in combination with SCT510, a bevacizumab biosimilar, versus sorafenib in unresectable advanced HCC. This randomized phase …
View article: 108. SELECTIVE POTENTIATION OF α5-GABAA RECEPTORS CONTRIBUTES TO REDUCTION OF COGNITIVE BURDEN AND NEURONAL LOSS IN AGING MICE
108. SELECTIVE POTENTIATION OF α5-GABAA RECEPTORS CONTRIBUTES TO REDUCTION OF COGNITIVE BURDEN AND NEURONAL LOSS IN AGING MICE Open
Background Reduced GABA/somatostatin (SST) signaling is reported in aging as well as in psychiatric, stress-related and neurodegenerative disorders. Cortical SST+ interneurons inhibit the dendrites of excitatory neurons, largely through α5…
View article: Analysis of clinicopathological characteristics and prognosis of appendiceal neuroendocrine tumors: a retrospective cohort study based on the SEER database
Analysis of clinicopathological characteristics and prognosis of appendiceal neuroendocrine tumors: a retrospective cohort study based on the SEER database Open
ANETs patients generally present with early-stage disease and favorable prognosis. However, the males and the elders tend to have worse prognosis than their female and younger counterparts. These findings suggest that closer monitoring and…
View article: Predicting hemorrhage expansion in patients with hypertensive intracerebral hemorrhage: the HE-VSD-A2TP score
Predicting hemorrhage expansion in patients with hypertensive intracerebral hemorrhage: the HE-VSD-A2TP score Open
Background Hematoma expansion (HE) in hypertensive intracerebral hemorrhage (HICH) is significantly associated with patient mortality. Early identification of HE would be planning for appropriate and aggressive management for improving out…
View article: Pharmacological Intervention with 4-Phenylbutyrate Ameliorates TiAl6V4 Nanoparticles-Induced Inflammatory Osteolysis by Promoting Macrophage Apoptosis
Pharmacological Intervention with 4-Phenylbutyrate Ameliorates TiAl6V4 Nanoparticles-Induced Inflammatory Osteolysis by Promoting Macrophage Apoptosis Open
Macrophage apoptosis, along with inflammation in the interface membrane, has been demonstrated to be significant in the pathogenesis and development of particle-induced periprosthetic osteolysis and aseptic loosening. Additionally, the apo…
View article: CCDC 2401084: Experimental Crystal Structure Determination
CCDC 2401084: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The MASTL/YBX1/PAK4 axis regulated by stress-activated STK24 triggers lenvatinib resistance and tumor progression in HCC
The MASTL/YBX1/PAK4 axis regulated by stress-activated STK24 triggers lenvatinib resistance and tumor progression in HCC Open
Background and Aims: Many patients with HCC present inadequate responses to lenvatinib therapy. Therefore, it is important to elucidate the underlying mechanisms of resistance and to formulate effective reversal strategies. Approach and Re…
View article: P-343 Progesterone resistance related Renin-angiotensin system activation is involved in endometriosis
P-343 Progesterone resistance related Renin-angiotensin system activation is involved in endometriosis Open
Study question Whether renin-angiotensin system activation could be involved in endometriosis development and act as the key linking hypertension with endometriosis. Summary answer We proved that progesterone resistance related AGT-HEY1-GA…
View article: Aqueous-phase secondary organic aerosol formation on mineral dust
Aqueous-phase secondary organic aerosol formation on mineral dust Open
Secondary organic aerosol (SOA) is a significant component of airborne particles that impacts air quality, health, and climate globally. Aqueous-phase reactions contribute substantially to SOA mass. However, this process is primarily treat…