Shuwei Chen
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View article: The methyltransferase N6amt1 regulates hippocampal neurogenesis through 6 mA modification of Txnrd3 DNA
The methyltransferase N6amt1 regulates hippocampal neurogenesis through 6 mA modification of Txnrd3 DNA Open
N6-methyladenine (6 mA), the most prevalent DNA modification in mammals and other eukaryotes, regulates DNA mismatch repair, chromosome replication, and transcription. However, its role in adult hippocampal neurogenesis remains unkown. Her…
View article: Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas
Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas Open
Lymphatic metastasis is a well-known factor for initiating distant metastasis of head and neck squamous cell carcinoma (HNSCC), which caused major death in most patients with cancer. Meanwhile, metabolic reprogramming to support metastasis…
View article: Factors Associated with IgG/IgM Levels after SARS-CoV-2 Vaccination in Patients with Head and Neck Cancer
Factors Associated with IgG/IgM Levels after SARS-CoV-2 Vaccination in Patients with Head and Neck Cancer Open
This study evaluated the factors influencing IgG/IgM antibody levels in 120 patients with head and neck cancer (HNC) following vaccination with inactivated SARS-CoV-2 vaccines. Each patient’s demographic and clinical data were documented, …
View article: Deciphering the interplay of HPV infection, MHC-II expression, and CXCL13+ CD4+ T cell activation in oropharyngeal cancer: implications for immunotherapy
Deciphering the interplay of HPV infection, MHC-II expression, and CXCL13+ CD4+ T cell activation in oropharyngeal cancer: implications for immunotherapy Open
Background Human papillomavirus (HPV) infection has become an important etiological driver of oropharyngeal squamous cell carcinoma (OPSCC), leading to unique tumor characteristics. However, the interplay between HPV-associated tumor cells…
View article: m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA Open
Background N 1 -Methyladenosine (m 1 A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m 1 A modification in adult hippocampal …
View article: Clinicopathologic characteristics of HPV-associated head and neck squamous cell carcinoma in Southern China: long-term retrospective study of 400 cases
Clinicopathologic characteristics of HPV-associated head and neck squamous cell carcinoma in Southern China: long-term retrospective study of 400 cases Open
Background: Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is an evolving and growing disease, especially in developing countries. However, the clinical characteristics of HPV-associated HNSCC in regard…
View article: Resection of rectal metastasis after previous radical surgery for pancreatic cancer: Case report and literature review
Resection of rectal metastasis after previous radical surgery for pancreatic cancer: Case report and literature review Open
Rationale: Pancreatic ductal adenocarcinoma (PDAC) is the main type of pancreatic cancer with a poor prognosis. Rectal metastasis after radical resection of PDAC is comparatively rare, and the understanding of such cases is currently not u…
View article: Light and endogenous enzyme triggered plasmonic antennas for accurate subcellular molecular imaging with enhanced spatial resolution
Light and endogenous enzyme triggered plasmonic antennas for accurate subcellular molecular imaging with enhanced spatial resolution Open
Light and endogenous APE1-triggered plasmonic antennas were developed for accurate tumor-specific subcellular molecular imaging with enhanced spatial resolution.
View article: Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery
Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery Open
Objective Transoral robotic surgery (TORS) has become an effective treatment for early‐stage oropharyngeal squamous cell carcinomas (OPSCCs). We aimed to analyze the clinical safety and efficacy of TORS for human papilloma virus (HPV)‐posi…
View article: Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection
Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection Open
The significance of postoperative radiotherapy (PORT) to the neck for pN1 status head and neck squamous cell carcinomas (HNSCC) after neck dissection is unclear. A total of 208 patients with pN1 status HNSCC treated from January 1, 2001, t…
View article: A novel systemic inflammatory-nutritional score (INS) and nomogram for the prognostic prediction of adult head and neck soft tissue sarcoma in patients undergoing R0 surgery
A novel systemic inflammatory-nutritional score (INS) and nomogram for the prognostic prediction of adult head and neck soft tissue sarcoma in patients undergoing R0 surgery Open
Background Head and neck soft tissue sarcoma (HNSTS) comprises a rare group of malignancies with high risks of recurrence and mortality. However, the biomarkers predicting the prognosis of HNSTS patients received R0 resection are limited. …
View article: Selenite Induces Cell Cycle Arrest and Apoptosis via Reactive Oxygen Species-Dependent Inhibition of the AKT/mTOR Pathway in Thyroid Cancer
Selenite Induces Cell Cycle Arrest and Apoptosis via Reactive Oxygen Species-Dependent Inhibition of the AKT/mTOR Pathway in Thyroid Cancer Open
Thyroid cancer is the most common endocrine malignancy, and its incidence has increased in the past decades. Selenium has been shown to have therapeutic effects against several tumors. However, its role in thyroid cancer and its underlying…
View article: Single‐cell transcriptomics reveal the intratumoral landscape of infiltrated T‐cell subpopulations in oral squamous cell carcinoma
Single‐cell transcriptomics reveal the intratumoral landscape of infiltrated T‐cell subpopulations in oral squamous cell carcinoma Open
Systematic analysis of tumor‐infiltrating lymphocytes is essential for the development of new cancer treatments and the prediction of clinical responses to immunotherapy. Immunomodulatory drugs are used for the treatment of oral squamous c…
View article: Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p
Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p Open
Background Myeloid-derived suppressor cells (MDSCs) have become increasingly recognized as facilitators of tumor development. However, the role of MDSCs in papillary thyroid carcinoma (PTC) progression has not been clearly explored. Object…
View article: High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma
High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma Open
According to our previous study, GOLPH3 is markedly up‐expressed in tongue squamous cell carcinoma (TSCC), which is also associated with poor survival. However, it remains unclear about key upstream and downstream mechanisms of GOLPH3. Thi…
View article: TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion
TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion Open
Background . Ten-eleven translocation (TET) enzymes catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) promoting demethylation in cells. However, the expression pattern and biologic significance of TET in pa…
View article: Expression of PD-1/PD-L1 in head and neck squamous cell carcinoma and its clinical significance
Expression of PD-1/PD-L1 in head and neck squamous cell carcinoma and its clinical significance Open
Objective: To investigate the role of programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), and P16 in patients with head and neck squamous cell carcinoma (HNSCC). Methods: A total of 95 paraffin-embedded samples of tumorous tissue…
View article: miR-3619-3p promotes papillary thyroid carcinoma progression via Wnt/β-catenin pathway
miR-3619-3p promotes papillary thyroid carcinoma progression via Wnt/β-catenin pathway Open
miR-3619-3p promoted PTC cell migration and invasion as an oncogene via activating the Wnt/β-catenin pathway through increasing the stability of β-catenin.
View article: <p>Secreted TGF-beta-induced protein promotes aggressive progression in bladder cancer cells</p>
Secreted TGF-beta-induced protein promotes aggressive progression in bladder cancer cells Open
Background: Transforming growth factor-beta-induced (TGFBI) is an exocrine protein, which has been found to be able to promote the development of nasopharyngeal carcinoma, glioma, pancreatic cancer, and other tumors. However, there is curr…
View article: Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution
Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution Open
The survival rate has steadily improved for OCC patients at this cancer center.
View article: Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study
Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study Open
To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A tot…
View article: A model combining TNM stage and tumor size shows utility in predicting recurrence among patients with hepatocellular carcinoma after resection
A model combining TNM stage and tumor size shows utility in predicting recurrence among patients with hepatocellular carcinoma after resection Open
We established a novel and effective equation for predicting the probability of recurrence and OS after curative resection. Patients with a high recurrence score, based on this equation, should undergo additional high-end imaging examinati…
View article: Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy Open
Second primary gingival squamous cell carcinoma after radiotherapy demonstrated particular clinicopathologic features, such as prominent sites and TNM stage; and there was statistically significant difference in 5-year overall survival and…
View article: Co-integration Analysis of Rural Labor Non-agricultural Activities and Household Income
Co-integration Analysis of Rural Labor Non-agricultural Activities and Household Income Open
\nThe role of non-agricultural activities of rural labors in their household income is a noteworthy topic. This paper focuses on the long-term and stable equilibrium relationship between the two. Based on 1985 - 2012 Statistical Yearbook d…