Chen Lesnik
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View article: Enhanced Branched-Chain Amino Acid Metabolism Improves Age-Related Reproduction in<i>C. elegans</i>
Enhanced Branched-Chain Amino Acid Metabolism Improves Age-Related Reproduction in<i>C. elegans</i> Open
Reproductive aging is one of the earliest human aging phenotypes, and mitochondrial dysfunction has been linked to oocyte quality decline. However, it is not known which mitochondrial metabolic processes are critical for oocyte quality mai…
View article: Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells
Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells Open
Embryonic stem cell (ESC) self-renewal and cell fate decisions are driven by a broad array of molecular signals. While transcriptional regulators have been extensively studied in human ESCs (hESCs), the extent to which RNA-binding proteins…
View article: Horizontal and vertical transmission of transgenerational memories via the<i>Cer1</i>transposon
Horizontal and vertical transmission of transgenerational memories via the<i>Cer1</i>transposon Open
Animals face both external and internal dangers: pathogens threaten from the environment, and unstable genomic elements threaten from within. Previously, we discovered that C. elegans protects itself from pathogens by “reading” bacterial s…
View article: Localized translation near the mitochondrial outer membrane: An update
Localized translation near the mitochondrial outer membrane: An update Open
Local synthesis of proteins near their activity site has been demonstrated in many biological systems, and has diverse contributions to cellular functions. Studies in recent years have revealed that hundreds of mitochondria-destined protei…