Yilong Chen
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View article: Gut microbiota dysbiosis and metabolic perturbations of bile/glyceric acids in major depressive disorder with IBS comorbidity
Gut microbiota dysbiosis and metabolic perturbations of bile/glyceric acids in major depressive disorder with IBS comorbidity Open
Major depressive disorder (MDD) and irritable bowel syndrome (IBS) exhibit high comorbidity, yet their shared pathophysiology remains unclear. Previous studies have primarily focused on the psychological health in the IBS population, witho…
View article: #2522 KDASDB: a comprehensive and user-friendly database for alternative splicing in kidney diseases
#2522 KDASDB: a comprehensive and user-friendly database for alternative splicing in kidney diseases Open
Background and Aims Kidney disease has been a major public health concern for many years, and understanding its causes, mechanisms, and progression is crucial for developing effective prevention and treatment strategies. Alternative splici…
View article: Advantageous Parameter Expansion Training Makes Better Large Language Models
Advantageous Parameter Expansion Training Makes Better Large Language Models Open
Although scaling up the number of trainable parameters in both pre-training and fine-tuning can effectively improve the performance of large language models, it also leads to increased computational overhead. When delving into the paramete…
View article: Exploring oral microbiome in oral squamous cell carcinoma across environment-associated sample types
Exploring oral microbiome in oral squamous cell carcinoma across environment-associated sample types Open
The relationship between the oral microbiome and oral squamous cell carcinoma (OSCC) has been extensively investigated. Nonetheless, most previous studies were single-center, resulting in the absence of systematic evaluations. To address t…
View article: Transcription factor ATF3 aggravates kidney fibrosis by maintaining the state of histone H3 lysine 27 acetylation
Transcription factor ATF3 aggravates kidney fibrosis by maintaining the state of histone H3 lysine 27 acetylation Open
Background: Chronic kidney disease (CKD) is a global health issue, with renal fibrosis being a common pathway in CKD development. Histone modification plays crucial roles in transcriptional regulation, but their pathological functions and …
View article: KDASDB: A comprehensive and user-friendly database of alternative splicing dedicated to kidney diseases
KDASDB: A comprehensive and user-friendly database of alternative splicing dedicated to kidney diseases Open
Kidney disease has long been a major public health concern, making it crucial to understand its causes, pathogenesis and progression for the development of effective prevention and treatment strategies. Alternative splicing (AS), an import…
View article: Design and Research of a Parallel Cable-Driven Force Feedback Master Hand
Design and Research of a Parallel Cable-Driven Force Feedback Master Hand Open
Teleoperation systems enable operators to interact with remote environments or robots, allowing for remote control and task execution even when not physically present at the task location. Teleoperation robots with force feedback capabilit…
View article: <i>LungDiag</i>: Empowering artificial intelligence for respiratory diseases diagnosis based on electronic health records, a multicenter study
<i>LungDiag</i>: Empowering artificial intelligence for respiratory diseases diagnosis based on electronic health records, a multicenter study Open
Respiratory diseases pose a significant global health burden, with challenges in early and accurate diagnosis due to overlapping clinical symptoms, which often leads to misdiagnosis or delayed treatment. To address this issue, we developed…
View article: Reassessing anionic redox in conventional layered oxide cathodes for Li-ion batteries: ionic and covalent mechanisms
Reassessing anionic redox in conventional layered oxide cathodes for Li-ion batteries: ionic and covalent mechanisms Open
Using synchrotron-based techniques, we studied the charge compensation in Ni–Co–Mn cathodes by analyzing electronic and geometric structures, with a focus on anion redox and local structural changes.
View article: The role of Sod-2 in different types of neuronal damage and behavioral changes induced by polystyrene nanoplastics in Caenorhabditis elegans
The role of Sod-2 in different types of neuronal damage and behavioral changes induced by polystyrene nanoplastics in Caenorhabditis elegans Open
Polystyrene nanoplastics (PS-NPs) have been demonstrated to accumulate in organisms especially from soil and exhibit neurotoxicity. However, the specific mechanisms by which PS-NPs caused neurotoxic effects remain largely unexplored. In th…
View article: TNMpBC-NeoBCSS model: A Breast Cancer Specific Survival Prediction Model for Triple-negative Metaplastic Breast Carcinoma Patients with Neoadjuvant Therapy
TNMpBC-NeoBCSS model: A Breast Cancer Specific Survival Prediction Model for Triple-negative Metaplastic Breast Carcinoma Patients with Neoadjuvant Therapy Open
Background: The breast cancer specific survival (BCSS) benefits of Neoadjuvant therapy (NeoAT) for triple-negative metaplastic breast cancer (TNMpBC) was uncertain. This study aimed to develop a prediction model for assessing the BCSS for …
View article: The association between patterns of exposure to adverse life events and the risk of chronic kidney disease: a prospective cohort study of 140,997 individuals
The association between patterns of exposure to adverse life events and the risk of chronic kidney disease: a prospective cohort study of 140,997 individuals Open
Exposure to adverse life events is linked to somatic disorders. The study aims to evaluate the association between adverse events at varying life stages and the risk of chronic kidney disease (CKD), a condition affecting about 10% populati…
View article: Unleashing the Power of Emojis in Texts via Self-supervised Graph Pre-Training
Unleashing the Power of Emojis in Texts via Self-supervised Graph Pre-Training Open
Emojis have gained immense popularity on social platforms, serving as a common means to supplement or replace text. However, existing data mining approaches generally either completely ignore or simply treat emojis as ordinary Unicode char…
View article: Non-target Divergence Hypothesis: Toward Understanding Domain Gaps in Cross-Modal Knowledge Distillation
Non-target Divergence Hypothesis: Toward Understanding Domain Gaps in Cross-Modal Knowledge Distillation Open
Compared to single-modal knowledge distillation, cross-modal knowledge distillation faces more severe challenges due to domain gaps between modalities. Although various methods have proposed various solutions to overcome these challenges, …
View article: Bioinformatic approaches of liquid–liquid phase separation in human disease
Bioinformatic approaches of liquid–liquid phase separation in human disease Open
Biomolecular aggregation within cellular environments via liquid–liquid phase separation (LLPS) spontaneously forms droplet-like structures, which play pivotal roles in diverse biological processes. These structures are closely associated …
View article: [Cluster Analysis and Ablation Success Rate in Atrial Fibrillation Patients Undergoing Catheter Ablation].
[Cluster Analysis and Ablation Success Rate in Atrial Fibrillation Patients Undergoing Catheter Ablation]. Open
This study provided a unique classification of AF patients undergoing catheter ablation by cluster analysis. Age, chronic disease, sinus node dysfunction, heart failure and history of coronary artery revascularization contributed to the fo…
View article: Bacterial interactome disturbance in chronic obstructive pulmonary disease clinical stability and exacerbations
Bacterial interactome disturbance in chronic obstructive pulmonary disease clinical stability and exacerbations Open
Rationale Our understanding of airway dysbiosis in chronic obstructive pulmonary disease (COPD) remains incomplete, which may be improved by unraveling the complexity in microbial interactome. Objectives To characterize reproducible featur…
View article: Weakly Supervised LiDAR Semantic Segmentation via Scatter Image Annotation
Weakly Supervised LiDAR Semantic Segmentation via Scatter Image Annotation Open
Weakly supervised LiDAR semantic segmentation has made significant strides with limited labeled data. However, most existing methods focus on the network training under weak supervision, while efficient annotation strategies remain largely…
View article: Beyond Gait: Learning Knee Angle for Seamless Prosthesis Control in Multiple Scenarios
Beyond Gait: Learning Knee Angle for Seamless Prosthesis Control in Multiple Scenarios Open
Deep learning models have become a powerful tool in knee angle estimation for lower limb prostheses, owing to their adaptability across various gait phases and locomotion modes. Current methods utilize Multi-Layer Perceptrons (MLP), Long-S…
View article: Enhanced oxygen reduction activity of <i>α</i>-MnO<sub>2</sub> by NH<sub>3</sub> plasma treatment
Enhanced oxygen reduction activity of <i>α</i>-MnO<sub>2</sub> by NH<sub>3</sub> plasma treatment Open
Oxygen vacancies and heteroatom doping play important role in oxygen reduction activity of metal oxides. Developing efficient modification method is one of the key issues in catalysts research. Room temperature plasma treatment, with the a…
View article: Predicting the distribution and characteristics of Chinese pangolin habitat in China: Implications for conservation
Predicting the distribution and characteristics of Chinese pangolin habitat in China: Implications for conservation Open
The Chinese pangolin (Manis pentadactyla) is on the verge of extinction. Overuse and habitat loss have decimated the pangolin population across China. Understanding the habitat status of pangolins is a prerequisite for conservation, but th…
View article: Towards Large-scale Probabilistic Set Covering Problem: An Efficient Benders Decomposition Approach
Towards Large-scale Probabilistic Set Covering Problem: An Efficient Benders Decomposition Approach Open
In this paper, we investigate the probabilistic set covering problems (PSCP) in which the right-hand side is a random vector ξ and the covering constraint is required to be satisfied with a prespecified probability. We consider the case ar…
View article: A novel fast and efficient adaptive shuffled complex evolution algorithm for model parameter calibration
A novel fast and efficient adaptive shuffled complex evolution algorithm for model parameter calibration Open
The research and optimization of hydrological forecasting models are among the most crucial components in the scope of water management and flood protection. Optimizing the calibration of hydrological forecasting models is crucial for fore…
View article: Predicting suicidal behavior in individuals with depression over 50 years of age: Evidence from the UK biobank
Predicting suicidal behavior in individuals with depression over 50 years of age: Evidence from the UK biobank Open
Objective To construct applicable models suitable for predicting the risk of suicidal behavior among individuals with depression, particularly on the progression from no history of suicidal behavior to suicide attempts, as well as from sui…
View article: The Time-Varying Impact of COVID-19 on the Acute Kidney Disorders: A Historical Matched Cohort Study and Mendelian Randomization Analysis
The Time-Varying Impact of COVID-19 on the Acute Kidney Disorders: A Historical Matched Cohort Study and Mendelian Randomization Analysis Open
Background: This study aimed to explore the time-varying impact of COVID-19 on acute kidney disorders, including acute kidney injury and other acute kidney diseases. Methods: From the UK Biobank, 10,121 participants with COVID-19 were matc…