Explanipedia

Gag proteins encoded by endogenous retroviruses are required for zebrafish development Open

Ni‐Chen Chang, Jonathan N. Wells, Aili Wang, Phillip Schofield, Yi-Chia Huang , et al. · 2025

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. The process by which TEs become coopted remains obscure because most cases involve ancient, …

Gag proteins encoded by endogenous retroviruses are required for zebrafish development Open

Ni‐Chen Chang, Jonathan N. Wells, Andrew Y. Wang, Phillip Schofield, Yi-Chia Huang , et al. · 2024

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. The process by which TEs become coopted remains obscure because most cases involve ancient, …

Transposable elements drive the evolution of metazoan zinc finger genes Open

Jonathan N. Wells, Ni‐Chen Chang, John K. McCormick, Caitlyn Coleman, Nathalie Ramos , et al. · 2023

Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and contraction of numerous subfamilies across the animal phylogeny.…

Transposable elements drive the evolution of metazoan zinc finger genes Open

Jonathan N. Wells, Ni‐Chen Chang, John K. McCormick, Caitlyn Coleman, Nathalie Ramos , et al. · 2022

Cys2-His2 Zinc finger genes (ZNFs) form the largest family of transcription factors in metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and contraction of numerous subfamilies across the animal phylogeny.…

Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression Open

Ni-Chen Chang, Quirze Rovira, Jonathan Wells, Cedric Feschotte, Juan M. Vaquerizas , et al. · 2022

There is considerable interest in understanding the effect of transposable elements (TEs) on embryonic development. Studies in humans and mice are limited by the difficulty of working with mammalian embryos and by the relative scarcity of …

phiC31 integrase for recombination-mediated single-copy insertion and genome manipulation in Caenorhabditis elegans Open

Fang-Jung Yang, Chiao-Nung Chen, Tiffany Chang, Ting-Wei Cheng, Ni‐Chen Chang , et al. · 2021

Caenorhabditis elegans benefits from a large set of tools for genome manipulation. Yet, the precise single-copy insertion of very large DNA constructs (>10 kb) and the generation of inversions are still challenging. Here, we adapted the…

A genomic portrait of zebrafish transposable elements and their spatiotemporal embryonic expression Open

Ni‐Chen Chang, Quirze Rovira, Jonathan N. Wells, Cédric Feschotte, Juan M. Vaquerizas · 2021

There is considerable interest in understanding the effect of transposable elements (TEs) on embryonic development. Studies in humans and mice are limited by the difficulty of working with mammalian embryos, and by the relative scarcity of…

phiC31 integrase for recombination mediated single copy insertion and genome manipulation inC. elegans Open

Fang-Jung Yang, Chiao-Nung Chen, Tiffany Chang, Ting-Wei Cheng, Ni‐Chen Chang , et al. · 2020

C. elegans benefits from a large set of tools for genome manipulation. Yet, the insertion of large DNA constructs and the generation of inversions is still challenging. Here, we adapted the phiC31 integrase system for C. elegans. We genera…

Host–transposon interactions: conflict, cooperation, and cooption Open

Rachel Cosby, Ni‐Chen Chang, Cédric Feschotte · 2019

Transposable elements (TEs) are mobile DNA sequences that colonize genomes and threaten genome integrity. As a result, several mechanisms appear to have emerged during eukaryotic evolution to suppress TE activity. However, TEs are ubiquito…

Multiple large inversions and breakpoint rewiring of gene expression in the evolution of the fire ant social supergene Open

Yu‐Ching Huang, Viet Dai Dang, Ni‐Chen Chang, John Wang · 2018

Supergenes consist of co-adapted loci that segregate together and are associated with adaptive traits. In the fire ant Solenopsis invicta , two ‘social’ supergene variants regulate differences in colony queen number and other traits. Suppr…

orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants Open

Waring Trible, Leonora Olivos-Cisneros, Sean K. McKenzie, Jonathan Saragosti, Ni‐Chen Chang , et al. · 2017

orcomutagenesis causes loss of antennal lobe glomeruli and impaired social behavior in ants Open

Waring Trible, Ni‐Chen Chang, Benjamin J. Matthews, Sean K. McKenzie, Leonora Olivos-Cisneros , et al. · 2017

Life inside ant colonies is orchestrated with a diverse set of pheromones, but it is not clear how ants perceive these social cues. It has been proposed that pheromone perception in ants evolved via expansions in the numbers of odorant rec…

Additional file 1: of Evolution of long centromeres in fire ants Open