Sheng Chen
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View article: Case Report: Severe psittacosis in an elderly patient without avian exposure: diagnosis via metagenomic next-generation sequencing and rapid response to doxycycline
Case Report: Severe psittacosis in an elderly patient without avian exposure: diagnosis via metagenomic next-generation sequencing and rapid response to doxycycline Open
Chlamydia psittaci causes psittacosis in both birds and humans, typically following avian exposure. We present a case of severe psittacosis in a 73-year-old woman with no documented bird contact. The diagnosis was ultimately achieved throu…
View article: Real-world adverse event analysis of Adagrasib: Insights from the FAERS database
Real-world adverse event analysis of Adagrasib: Insights from the FAERS database Open
Adagrasib is a potent and orally available small-molecule inhibitor that irreversibly targets the KRAS G12C mutant isoform. This innovative therapeutic agent represents a significant advancement in the field of oncology, offering a targete…
View article: Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent <i>Klebsiella pneumoniae</i>
Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent <i>Klebsiella pneumoniae</i> Open
The emergence of hypervirulent carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) represents an alarming convergence of enhanced virulence and extensive drug resistance. Here, we present a comprehensive genomic analysis of 2563 clonal com…
View article: MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway
MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway Open
The MRPL35/ROS/JNK/NF-κB signaling pathway plays a critical role in the pathogenesis of PNAC. Targeting MRPL35 is expected to alleviate liver injury by blocking mitochondrial ROS signaling, offering a novel precision treatment model target…
View article: Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing
Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing Open
RNA modifications play crucial roles in prokaryotic cellular processes. In this study, we found that the recent advances in direct RNA sequencing have improved yield, accuracy, and signal-to-noise ratio in bacterial samples. By evaluating …
View article: Highly Expressed <scp>NELFE</scp> in Tumor Cells at the Invasive Tumor Front Was a Prognostic Biomarker for Oral Squamous Cell Carcinoma
Highly Expressed <span>NELFE</span> in Tumor Cells at the Invasive Tumor Front Was a Prognostic Biomarker for Oral Squamous Cell Carcinoma Open
Background Negative elongation factor E (NELFE) is a crucial subunit of the NELF complex, which plays pivotal roles in transcriptional regulation and cell fate. Despite the role of dysregulated NELFE in promoting the onset and progression …
View article: Exposure to the growth promoter tylosin elicits gut microbiota disruption and metabolic imbalance in mouse model
Exposure to the growth promoter tylosin elicits gut microbiota disruption and metabolic imbalance in mouse model Open
The environmental risk associated with the usage of the antibiotic tylosin as an animal growth promoter (AGPs) needs to be assessed because such agents are used in abundance and contamination of the environment is common, yet their effects…
View article: Transmission of tmexCD1-toprJ1-Positive Klebsiella pneumoniae Across Multiple Ecological Niches: A Global Epidemiological and Genomic Analysis
Transmission of tmexCD1-toprJ1-Positive Klebsiella pneumoniae Across Multiple Ecological Niches: A Global Epidemiological and Genomic Analysis Open
Tigecycline is one of the most critical drugs for treating Gram-negative bacterial infections; however, the emergence of the tigecycline resistance efflux pump TMexCD1-TOprJ1 poses a global health threat. The evolutionary relationships and…
View article: Microspheric hierarchical controlled-release system and cell growth platform achieves sequential dual-exosomes delivery and promote bone regeneration
Microspheric hierarchical controlled-release system and cell growth platform achieves sequential dual-exosomes delivery and promote bone regeneration Open
The repair of jaw bone defects faces dual challenges of functionality and aesthetics. The scarcity of jawbone-derived stem cells and imprecise regulation of these endogenous stem cells lead to uncertainties in osteogenic quality and speed.…
View article: Highly Expressed PARP1 in Tumor Cells at the Invasive Tumor Front Was a Prognostic Biomarker for Oral Squamous Cell Carcinoma
Highly Expressed PARP1 in Tumor Cells at the Invasive Tumor Front Was a Prognostic Biomarker for Oral Squamous Cell Carcinoma Open
Background: Poly(ADP-ribose) polymerase-1 (PARP-1) is a protein involved in multiple physiological processes. Elevated PARP-1 expression has been found in several tumors, being associated with stemness and tumorigenesis. Despite dysregulat…
View article: New Paradigm for Integrated Sensing and Communication with Rydberg Atomic Receiver
New Paradigm for Integrated Sensing and Communication with Rydberg Atomic Receiver Open
The RYDberg Atomic Receiver (RYDAR) has been demonstrated to surmount the limitation on both the sensitivity and operating bandwidth of the classical electronic counterpart, which can theoretically detect indiscernible electric signals bel…
View article: Influence of Potential Vorticity Generated by Diabatic Cooling over the Tibetan Plateau on the Surface Air Temperature of Eastern China during Boreal Winter
Influence of Potential Vorticity Generated by Diabatic Cooling over the Tibetan Plateau on the Surface Air Temperature of Eastern China during Boreal Winter Open
Using reanalysis and model data, this study investigates potential vorticity (PV) generated by diabatic cooling over the Tibetan Plateau (TP) and its associated climatic effects on adjacent regions. Results suggest that anomalous diabatic …
View article: Genetic insights into Shewanella spp., progenitor of the bla OXA-48-like genes: a large-scale study
Genetic insights into Shewanella spp., progenitor of the bla OXA-48-like genes: a large-scale study Open
Shewanella spp. played pivotal ecological roles and were reported to be the progenitor of bla OXA-48 -like carbapenemase genes. However, it remained unknown which species was the progenitor of different OXA-48 carbapenemase variants. To ad…
View article: Efgartigimod combined with steroids as a fast-acting therapy for anti-SRP immune-mediated necrotizing myopathy
Efgartigimod combined with steroids as a fast-acting therapy for anti-SRP immune-mediated necrotizing myopathy Open
Background Immune-mediated necrotizing myopathy (IMNM) is a rare autoimmune disease. Efgartigimod is a human IgG antibody Fc fragment, can enhance the degradation of IgG and thus may be a promising therapeutic agent for IMNM. Methods All t…
View article: Fabrication of a Lipopolysaccharide‐Targeting Peptide‐Based Colloid for Alleviating Carbapenem‐Resistant <i>Enterobacteriaceae</i>‐Induced Cutaneous Infection
Fabrication of a Lipopolysaccharide‐Targeting Peptide‐Based Colloid for Alleviating Carbapenem‐Resistant <i>Enterobacteriaceae</i>‐Induced Cutaneous Infection Open
Carbapenem‐resistant Enterobacteriaceae (CRE) becomes a growing threat to human health. Many clinical isolates have shown strong resistance to commonly used antibacterial agents. Inspired by cationic amphiphiles with tandem‐repeat sequence…
View article: Development and validation of a multivariate nomogram for predicting retinopathy of prematurity in infants with gestational age ≤34 weeks
Development and validation of a multivariate nomogram for predicting retinopathy of prematurity in infants with gestational age ≤34 weeks Open
Purpose To delineate risk factors and develop a predictive nomogram for retinopathy of prematurity (ROP) in infants with gestational age (GA) ≤34 weeks. Methods We conducted a comprehensive retrospective analysis of infants with GA ≤34 wee…
View article: Research on the Method of Air Traffic Control Instruction Keyword Extraction Based on the Roberta-Attention-BiLSTM-CRF Model
Research on the Method of Air Traffic Control Instruction Keyword Extraction Based on the Roberta-Attention-BiLSTM-CRF Model Open
In recent years, with the increasing complexity of air traffic management and the rapid development of automation technology, efficiently and accurately extracting key information from large volumes of air traffic control (ATC) instruction…
View article: Adaptive Helpfulness-Harmlessness Alignment with Preference Vectors
Adaptive Helpfulness-Harmlessness Alignment with Preference Vectors Open
Ensuring that large language models (LLMs) are both helpful and harmless is a critical challenge, as overly strict constraints can lead to excessive refusals, while permissive models risk generating harmful content. Existing approaches, su…
View article: Research on the dynamic evolution mechanism of disruptive technology based on the BERTopic model and Hidden Markov Model: A case study of industrial Internet technology
Research on the dynamic evolution mechanism of disruptive technology based on the BERTopic model and Hidden Markov Model: A case study of industrial Internet technology Open
Objective The development of key technologies for the Industrial Internet is a major concern for countries worldwide. This paper aims to comprehensively understand the technology of the Industrial Internet by analyzing its current applicat…
View article: Synthesis of <i>Campylobacter jejuni</i> capsular oligosaccharides and identification of a potential <i>O</i> -antigen against campylobacteriosis
Synthesis of <i>Campylobacter jejuni</i> capsular oligosaccharides and identification of a potential <i>O</i> -antigen against campylobacteriosis Open
The vaccines against campylobacteriosis are urgently needed because of the rising multidrug resistance of pathogenic Campylobacter jejuni . The capsular polysaccharides of these bacteria, containing unique 6-deoxy-β- d - ido -heptopyranosy…
View article: Fasting influences the muscle quality of fish during transportation by regulating the balance between energy metabolism and ammonia nitrogen stress
Fasting influences the muscle quality of fish during transportation by regulating the balance between energy metabolism and ammonia nitrogen stress Open
Our data concluded that fasting affects cell apoptosis by regulating the balance between energy metabolism and stress, ultimately impacting muscle quality. For long-distance transportation, a fasting period of 2-3 d is optimal.
View article: Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in <i>Klebsiella pneumoniae</i>
Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in <i>Klebsiella pneumoniae</i> Open
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hv Kp ) has led to a high mortality rate in the clinical setting and garnered significant attention in the clinical and scientific communities. It is still not clear which major …
View article: Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production
Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production Open
Klebsiella pneumoniae ( Kp ) is responsible for a wide range of infections, including pneumonia, sepsis, and urinary tract infections. However, the treatment options are limited due to the continuous evolution of drug-resistant and hypervi…
View article: Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023
Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023 Open
Our results highlight frequent clonal transmission of polymyxin-resistant CRKP within hospitals. Continuous surveillance of polymyxin resistance among CRKP should be implemented to prevent further dissemination of such strains in clinical …