Ta‐Chen Su
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View article: CD147 at the crossroads of glycoprotein networks, metabolic reprogramming, and metastatic progression
CD147 at the crossroads of glycoprotein networks, metabolic reprogramming, and metastatic progression Open
CD147 (also known as EMMPRIN or Basigin), a transmembrane glycoprotein of the immunoglobulin superfamily, functions as a pivotal regulator of tumor progression. It coordinates key oncogenic processes—including metabolic adaptation, chemore…
View article: Associations Between PFAS Exposure and HPG Axis Hormones in U.S. Women
Associations Between PFAS Exposure and HPG Axis Hormones in U.S. Women Open
Purpose: This study aimed to investigate the associations between serum per- and polyfluoroalkyl substances (PFAS) and reproductive hormones, including follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), estradiol, and proges…
View article: Vitamin D and Central Blood Pressure: U-Shaped Risk and Copper Mediation
Vitamin D and Central Blood Pressure: U-Shaped Risk and Copper Mediation Open
Background Vitamin D deficiency has been implicated in cardiovascular risk, but its association with central blood pressure (cBP) and incident of hypertension in young Taiwanese adults remains unclear. Methods We analyzed 1,034 participant…
View article: Association Between Serum per- and Polyfluoroalkyl Substances and Iron Status Biomarkers in a Representative Sample of U.S. Adults: NHANES 2013–2018
Association Between Serum per- and Polyfluoroalkyl Substances and Iron Status Biomarkers in a Representative Sample of U.S. Adults: NHANES 2013–2018 Open
Purpose: Per- and polyfluoroalkyl substances (PFAS) comprise a class of man-made compounds widely utilized in manufacturing everyday consumer products. Experimental studies indicate that PFAS may interfere with iron regulation by hindering…
View article: Investigating the associations of blood lead and cadmium with smoking-related DNA methylation and mortality among U.S. adults
Investigating the associations of blood lead and cadmium with smoking-related DNA methylation and mortality among U.S. adults Open
Drawing from a nationally representative cohort of older U.S. adults, this study provides robust evidence linking blood lead and cadmium levels to smoking-related DNAm and increased mortality risk. Moreover, the analysis revealed additive …
View article: Wastewater SARS-CoV-2 monitoring in a university hospital forecasts multilevel epidemic curves in Taipei City, Taiwan
Wastewater SARS-CoV-2 monitoring in a university hospital forecasts multilevel epidemic curves in Taipei City, Taiwan Open
As COVID-19 shifts toward endemicity, ongoing surveillance remains critical to identifying and containing potential outbreaks, particularly in high-risk settings. Wastewater monitoring at targeted institutions offers a promising approach f…
View article: Medical accessibility and underreporting of occupational diseases: effect of travel distance and travel time
Medical accessibility and underreporting of occupational diseases: effect of travel distance and travel time Open
Objectives Underreporting of occupational diseases (ODs) could be attributed to poor medical accessibility, which is rarely discussed previously. Our cross-sectional study aims to evaluate how OD reporting is impeded by long travel distanc…
View article: Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018
Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018 Open
In this comprehensive analysis of NHANES data, our study identifies a potentially harmful relationship between glyphosate exposure and whole blood selenium levels. Notably, excessively high whole blood selenium levels may not only reduce t…
View article: Trajectories of cardiovascular risk factors during childhood as predictors of subclinical atherosclerosis in young adults
Trajectories of cardiovascular risk factors during childhood as predictors of subclinical atherosclerosis in young adults Open
Introduction Studies on cardiovascular risk factors in childhood/adolescence and subclinical cardiovascular disease in young Asian adults remain limited. The aim of this study was to investigate the effects of childhood cardiovascular risk…
View article: Modelling COVID-19 epidemic curve in Taipei City, Taiwan by a citywide wastewater SARS-CoV-2 Surveillance
Modelling COVID-19 epidemic curve in Taipei City, Taiwan by a citywide wastewater SARS-CoV-2 Surveillance Open
[[abstract]]Over 70 countries have adopted wastewater surveillance during the COVID-19 pandemic as a novel tool to detect unidentified cases and monitor epidemic curves. However, epidemic prediction models are highly site-specific, necessi…
View article: Cross-sectional study on the association between neutrophil-percentage-to-albumin ratio (NPAR) and prevalence of stroke among US adults: NHANES 1999–2018
Cross-sectional study on the association between neutrophil-percentage-to-albumin ratio (NPAR) and prevalence of stroke among US adults: NHANES 1999–2018 Open
The neutrophil-to-albumin ratio (NPAR) is a relatively novel composite biomarker of inflammation, which has been used for prognostication in cardiovascular diseases and may also be associated with stroke. A cross-sectional analysis was con…
View article: Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry
Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry Open
Background and Aims Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH…
View article: Genetic Variants in Severe Hypertriglyceridemia Among Taiwanese Participants ― Insights From Genome-Wide Association and Whole-Exome Sequencing Analyses ―
Genetic Variants in Severe Hypertriglyceridemia Among Taiwanese Participants ― Insights From Genome-Wide Association and Whole-Exome Sequencing Analyses ― Open
Our study confirms the role of known genetic loci in triglyceride metabolism and hypertriglyceridemia while uncovering novel loci, offering new perspectives on lipid regulation and potential avenues for therapeutic advancements.
View article: The Role of Lipid Metabolism in Dyslipidemias and Atherosclerosis
The Role of Lipid Metabolism in Dyslipidemias and Atherosclerosis Open
Atherosclerotic cardiovascular disease is a major burden of morbidity and, despite recent therapeutic advances, is the leading cause of mortality worldwide [...]
View article: 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part II.
2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part II. Open
For the primary prevention of atherosclerotic cardiovascular disease (ASCVD), the recommended treatment target for each modifiable risk factor is as follows: reducing body weight by 5-10%; blood pressure < 130/80 mmHg (systolic pressure < …
View article: 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.
2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I. Open
Atherosclerotic cardiovascular disease (ASCVD) is one of the leading causes of death worldwide and in Taiwan. It is highly prevalent and has a tremendous impact on global health. Therefore, the Taiwan Society of Cardiology developed these …
View article: Impaired lung function and lung cancer risk in 461 183 healthy individuals: a cohort study
Impaired lung function and lung cancer risk in 461 183 healthy individuals: a cohort study Open
Background It has been known that smoking and various lung diseases including lung cancer can cause lung function impairment. However, the impact of different types of lung function impairments, such as preserved ratio impaired spirometry …
View article: COVID‐19 Infection Risk Assessment in a Kindergarten Utilizing Continuous Air Quality Monitoring Data
COVID‐19 Infection Risk Assessment in a Kindergarten Utilizing Continuous Air Quality Monitoring Data Open
Researchers and transnational public health organizations have recognized aerosol transmission as an essential route of COVID‐19 transmission. Therefore, improving ventilation systems is now adopted as a core preventive measure. As young c…
View article: Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults
Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults Open
This study provides evidence of an association between vitamin D deficiency and atherogenic dyslipidemia in young adults. It further highlights that individuals with serum 25(OH)D levels below 30 ng/mL are at a significantly higher risk of…