Chen Weller
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View article: Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation
Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation Open
Adoptive cell therapy (ACT) targeting tumor-specific antigens holds promise for solid tumors, but limited neoantigen presentation remains a key barrier to efficacy. Here, we identify and characterize a T cell receptor (TCR), T104, for the …
View article: Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer
Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer Open
New approaches that generate long-lasting therapeutic responses in patients with therapy-resistant metastatic cancer are urgently needed. To address this challenge, we developed Spot Neoantigens in Metastases (SpotNeoMet), a novel data-dri…
View article: Translation dysregulation in cancer as a source for targetable antigens
Translation dysregulation in cancer as a source for targetable antigens Open
Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized as foreign by T cells. Protein synthesis in malignant cells is dysregulated, which may r…
View article: Supplementary Table 3 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 3 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Pathway enrichment in samples at day 0 post-inoculation.
View article: Supplementary Table 8 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 8 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
List of antibodies used for IHC staining.
View article: Supplementary Figure 11 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 11 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Analysis of tissue microarray of biopsies from cancer patients.
View article: Supplementary Table 10 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 10 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
List of antibodies used for IHC staining of human samples.
View article: Supplementary Figure 8 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 8 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Supplementary data linked to the in vivo CRISPR screen.
View article: Supplementary Figure 7 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 7 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Rejection and non-rejection gene sets identified in the scRNA sequencing analysis can stratify patients with high/low ITH and hot/cold tumor annotations.
View article: Supplementary Table 9 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 9 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
List of antibodies used for CODEX multiplexed tissue imaging
View article: Supplementary Figure 12 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 12 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Evaluation of Mif expression in stromal cells, and its effect on patient survival.
View article: Supplementary Table 4 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 4 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Pathway enrichment in samples at days 6, 10, 16, and 20 post-inoculation.
View article: Supplementary Table 6 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 6 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
CRISPR pooled guide library constructs
View article: Supplementary Figure 14 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 14 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Transcriptional changes in the Mif KO compared to Mif WT tumors.
View article: Supplementary Figure 15 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 15 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
CyTOF analysis comparing tumors derived from Mif WT and Mif KO validating the scRNAseq findings.
View article: Supplementary Figure 2 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 2 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Immunopeptidomics and TCR sequencing analyses showed similar results for the rejected and non-rejected SCCs.
View article: Supplementary Table 5 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 5 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Differentially expressed genes in tumor compartment at days 0, 6, 10, and 16 post-inoculation.
View article: Supplementary Figure 3 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 3 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Cell types from scRNA-seq of tumors from mice inoculated with rejected or non-rejected SCCs.
View article: Supplementary Table 7 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 7 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
List of primers used for sgRNA library generation
View article: Data from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Data from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Low intratumor heterogeneity correlates with increased patient survival and immunotherapy response. However, even highly homogeneous tumors are variably aggressive, and the immunologic factors impacting aggressiveness remain understudied. …
View article: Supplementary Figure 10 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 10 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Highest Mif expression was found in tumor cells, compared to other cell types.
View article: Supplementary Figure 16 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 16 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
CD8+ T cell depletion data. Supplemental figure to Figure 6F.
View article: Supplementary Table 1 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 1 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
WES analysis for all mouse SCCs and UVB-treated samples.
View article: Supplementary Table 2 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Table 2 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Non-silent mutations per SCC.
View article: Supplementary Figure 4 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 4 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Opal and CODEX multiplexed tissue imaging data shows infiltration of proliferative CD8+ T-cells to the rejected SCCs.
View article: Supplementary Figure 13 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 13 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
scRNA-seq characterization of Mif KO tumor clones.
View article: Supplementary Figure 9 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 9 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
CellChat and CellPhoneDB analyses reveal increased MIF signaling from tumor cells to macrophages in non-rejected clones.
View article: Supplementary Figure 6 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 6 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Differential expression analysis of rejected vs. non-rejected tumor cells.
View article: Supplementary Figure 1 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Supplementary Figure 1 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma Open
Clinical data and characterization of the single-cell clones.