Yaping Chen
YOU?
Author Swipe
View article: Differential Effects of Endothelial Cell- as opposed to Neutrophil-Lineage Restricted PD-L1 Gene Expression on Experimental Murine Shock/ Sepsis-Induced Lung Injury
Differential Effects of Endothelial Cell- as opposed to Neutrophil-Lineage Restricted PD-L1 Gene Expression on Experimental Murine Shock/ Sepsis-Induced Lung Injury Open
Introduction: Our laboratory and others have shown that Programmed cell death receptor-Ligand 1 (PD-L1), contributes to the development of shock/ sepsis induced morbidity/ mortality, but its role appears to vary across organ/cell type. Obj…
View article: Physcion-8-O-β-D-monoglucoside protects hepatocytes from TNF-α-mediated apoptosis by suppressing the PI3K/AKT /NF-κB signaling pathway
Physcion-8-O-β-D-monoglucoside protects hepatocytes from TNF-α-mediated apoptosis by suppressing the PI3K/AKT /NF-κB signaling pathway Open
Physcion-8-O-β-D-monoglucoside (PMG) is one of the active ingredients of Radix et Rhizoma Rhei, which had been used for treating liver disorders for hundreds of years in China. However, the hepatoprotective effects of PMG remain poorly und…
View article: Isorhamnetin attenuates renal interstitial fibrosis by targeting TWEAK/Fn14-mediated epithelial–mesenchymal transition
Isorhamnetin attenuates renal interstitial fibrosis by targeting TWEAK/Fn14-mediated epithelial–mesenchymal transition Open
Introduction Isorhamnetin (ISO), a prominent active compound found in the fruits of Hippophae rhamnoides L., exhibits various pharmacological activities. Recent studies have demonstrated that ISO possesses a significant renoprotective effe…
View article: Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathway
Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathway Open
Fibroblast‑like synoviocytes (FLSs) are the primary drivers of synovial tissue hyperplasia in rheumatoid arthritis (RA). Activation of the tumor necrosis factor‑like weak inducer of apoptosis (TWEAK)/fibroblast growth factor‑inducible imme…
View article: <scp>HIV</scp>‐negative primary effusion lymphoma: a series of seven cases
<span>HIV</span>‐negative primary effusion lymphoma: a series of seven cases Open
Aims Primary effusion lymphoma (PEL) is a rare aggressive, human herpesvirus‐8 (HHV8)‐associated neoplasm of post‐germinal centre B cell origin. It usually presents as a serous effusion in human immunodeficiency virus (HIV)‐positive patien…
View article: Rapid Radiation of a Plant Lineage Sheds Light on the Assembly of Dry Valley Biomes
Rapid Radiation of a Plant Lineage Sheds Light on the Assembly of Dry Valley Biomes Open
Southwest China is characterized by high plateaus, large mountain systems, and deeply incised dry valleys formed by major rivers and their tributaries. Despite the considerable attention given to alpine plant radiations in this region, the…
View article: Surveillance of Adverse Events Following Varicella Vaccine Immunization in Zhejiang Province, China, from 2020 to 2022
Surveillance of Adverse Events Following Varicella Vaccine Immunization in Zhejiang Province, China, from 2020 to 2022 Open
Background: China has a high incidence rate of varicella yet a low coverage rate of the varicella vaccine (VarV), with safety concerns being a leading cause of the lack of vaccination willingness. This study aimed to describe VarV-related …
View article: Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo
Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo Open
Object Neuroinflammation mediated by microglia has emerged as a critical factor in ischemic stroke and neuronal damage. Gualou Guizhi Granule (GLGZG) has been shown to suppress inflammation in lipopolysaccharide (LPS)-activated microglia, …
View article: Integrating D-Dimer Thresholds into the Revised Caprini Risk Stratification to Predict Deep Vein Thrombosis Risk in Preoperative Knee Osteoarthritis Patients
Integrating D-Dimer Thresholds into the Revised Caprini Risk Stratification to Predict Deep Vein Thrombosis Risk in Preoperative Knee Osteoarthritis Patients Open
Introduction Preoperative patients with knee osteoarthritis have a significantly increased risk of venous thromboembolism (VTE). While the Caprini risk assessment model offers some clinical guidance in predicting deep vein thrombosis (DVT)…
View article: Rheological Performance and UV Aging Resistance of Buton Rock Asphalt and Styrene-Butadiene-Styrene Composite Modified Asphalt Under High Temperature
Rheological Performance and UV Aging Resistance of Buton Rock Asphalt and Styrene-Butadiene-Styrene Composite Modified Asphalt Under High Temperature Open
This study aims to investigate the high-temperature rheological properties and ultraviolet (UV) aging resistance of Buton rock asphalt (BRA) and styrene-butadiene-styrene (SBS) composite modified asphalt. Initially, the surface morphology …
View article: The potential value of a quantitative PCR assay for assessing respiratory samples in approaching a laboratory diagnosis of pulmonary mucormycosis
The potential value of a quantitative PCR assay for assessing respiratory samples in approaching a laboratory diagnosis of pulmonary mucormycosis Open
•Mucorales qPCR aids in the aetiological diagnosis of breakthrough invasive fungal infections not responding to Aspergillus-targeted therapy.•Narrow hyphal widths (3−7 μm) were observed on histology of mucormycosis caused by Cunninghamella…
View article: Pudilan Anti-inflammatory Oral Liquid and Organic Acid Component from Taraxaci Herba Attenuate Allergic Asthma in Young Mice Through Toll-like Receptor 2/Toll-like Receptor 4 Signaling Pathway
Pudilan Anti-inflammatory Oral Liquid and Organic Acid Component from Taraxaci Herba Attenuate Allergic Asthma in Young Mice Through Toll-like Receptor 2/Toll-like Receptor 4 Signaling Pathway Open
Objective: Allergic asthma (AA) is a chronic airway inflammatory disease characterized by airway hyper-responsiveness (AHR). Pudilan anti-inflammatory oral liquid (PDL), along with its main medicinal material, Taraxaci Herba ( Taraxacum mo…
View article: Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy
Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy Open
Background Organoid technology is an emerging and rapidly growing field that shows promise in studying organ development and screening therapeutic regimens. Although organoids have been proposed for a decade, concerns exist, including batc…
View article: Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway
Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway Open
This study provides evidence that the combination of AM and its small molecule ononin can enhance the sensitivity of lung cancer to radiation. Additionally, it has been observed that this combination can specifically target HIF-1α and exer…
View article: Cost-effectiveness analysis of introducing rotavirus vaccine into immunization program in Zhejiang province, China: A decision tree-Markov model study
Cost-effectiveness analysis of introducing rotavirus vaccine into immunization program in Zhejiang province, China: A decision tree-Markov model study Open
Two RV vaccines have been licensed in Zhejiang province, China, including the pentavalent RotaTeq (RV5) and the monovalent RV vaccine (RV1). This study aimed to evaluate the cost-effectiveness of RV1 and RV5 to inform the prioritization of…
View article: Safety and Immunogenicity of Enterovirus 71 Vaccine (Vero Cell) Administered Simultaneously with Trivalent Split-Virion Influenza Vaccine in Infants Aged 6–7 Months: A Phase 4, Randomized, Controlled Trial
Safety and Immunogenicity of Enterovirus 71 Vaccine (Vero Cell) Administered Simultaneously with Trivalent Split-Virion Influenza Vaccine in Infants Aged 6–7 Months: A Phase 4, Randomized, Controlled Trial Open
Objective: To assess the immunogenicity and safety of the enterovirus 71 vaccine (Vero cell) (EV71 vaccine) and trivalent split-virion influenza vaccine (IIV3). Methods: Healthy infants aged 6–7 months were recruited from Zhejiang Province…
View article: Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung
Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung Open
Introduction Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a commonly occurring sequelae of traumatic injury resulting from indirect insults like hypovolemic shock and/or extrapulmonary sepsis. The high lethality ra…
View article: Signatures of immune cell infiltration for predicting immune escape and immunotherapy in cervical cancer
Signatures of immune cell infiltration for predicting immune escape and immunotherapy in cervical cancer Open
The cervical cancer tumor microenvironment is a diverse and complex ecosystem. Tumor-immune cell infiltration (ICI) may influence immune escape and immunotherapeutic responses. However, the relationship between immune cell infiltrations, i…
View article: The CXCL10/CXCR3 Pathway Contributes to the Synergy of Thermal Ablation and PD-1 Blockade Therapy against Tumors
The CXCL10/CXCR3 Pathway Contributes to the Synergy of Thermal Ablation and PD-1 Blockade Therapy against Tumors Open
As a practical local therapeutic approach to destroy tumor tissue, thermal ablation can activate tumor-specific T cells via enhancing tumor antigen presentation to the immune system. In the present study, we investigated changes in infiltr…
View article: Omicron variant of SARS-COV-2 in Shanghai: Clinical features and inactivated vaccine efficacy in 13,120 elderly patients
Omicron variant of SARS-COV-2 in Shanghai: Clinical features and inactivated vaccine efficacy in 13,120 elderly patients Open
Background: Few reports concerning inactivated vaccine efficacy in elderly patients with Omicron infection. We aimed at demonstrating the clinical characteristics of elderly patients with mild disease and assessing the protective effect of…
View article: Real-world safety profile of the 9-valent human papillomavirus vaccine: A study in Zhejiang, China from 2019 to 2021
Real-world safety profile of the 9-valent human papillomavirus vaccine: A study in Zhejiang, China from 2019 to 2021 Open
The safety profile of the 9-valent human papillomavirus vaccine (9vHPV) was evaluated based on the reporting rate of adverse events following immunization (AEFI) obtained from the passive surveillance data in Zhejiang. The 9vHPV AEFI repor…
View article: Immunogenicity and safety of an inactivated enterovirus 71 vaccine coadministered with trivalent split-virion inactivated influenza vaccine: A phase 4, multicenter, randomized, controlled trial in China
Immunogenicity and safety of an inactivated enterovirus 71 vaccine coadministered with trivalent split-virion inactivated influenza vaccine: A phase 4, multicenter, randomized, controlled trial in China Open
Background Few data exist on the immunogenicity and safety of an inactivated enterovirus 71 vaccine (EV71 vaccine) coadministered with trivalent split-virion inactivated influenza vaccine (IIV3) in infants. Methods This trial was a phase 4…