Yong Q. Chen
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View article: Human herpesvirus 6B infection in an adult with hemophagocytic lymphohistiocytosis carrying an UNC13D mutation: a case report and literature review
Human herpesvirus 6B infection in an adult with hemophagocytic lymphohistiocytosis carrying an UNC13D mutation: a case report and literature review Open
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. The cause of onset broadly distinguishes primary from acquired HLH. However, an increasing number of carrying HLH gene mutation cases have been repo…
View article: A 3D-Printed Transoral Guide Device to Aid Single-Person Fiberoptic Intubation: A Randomized Clinical Trial
A 3D-Printed Transoral Guide Device to Aid Single-Person Fiberoptic Intubation: A Randomized Clinical Trial Open
BACKGROUND Fiberoptic bronchoscopy-guided intubation (FOI) is a reliable method for managing difficult airways, typically requiring a 2-operator technique using jaw thrust. This study introduces a novel 3D-printed transoral guiding device …
View article: The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K/AKT signaling pathway
The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K/AKT signaling pathway Open
Extensive research has confirmed that omega-3 fatty acids provide cardiovascular protection primarily by activating the G protein-coupled receptor 120 (GPR120) signaling pathway. However, natural activators of this receptor often lack suff…
View article: Analysis of factors influencing tumor volume doubling time in hepatocellular carcinoma and its predictive value for progression-free survival
Analysis of factors influencing tumor volume doubling time in hepatocellular carcinoma and its predictive value for progression-free survival Open
This study aims to identify and analyze the factors that affect tumor volume doubling time (TVDT) in hepatocellular carcinoma (HCC) and evaluate how these factors impact progression-free survival. We performed a retrospective study on 183 …
View article: Assessment of the Impact of Dexmedetomidine on Myocardial Injury in TAVI Patients: A Retrospective Cohort Study Utilizing PSM-DID
Assessment of the Impact of Dexmedetomidine on Myocardial Injury in TAVI Patients: A Retrospective Cohort Study Utilizing PSM-DID Open
Dexmedetomidine administration during TAVI was associated with reduced levels of myocardial injury markers, indicating a potential cardioprotective role. By reducing myocardial injury, DEX may contribute to improved perioperative outcomes,…
View article: Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism
Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism Open
A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocortico…
View article: Effect of serratus anterior plane block combined with oxycodone for transition analgesia on preventing emergence agitation after video-assisted thoracoscopic surgery: a randomized controlled trial
Effect of serratus anterior plane block combined with oxycodone for transition analgesia on preventing emergence agitation after video-assisted thoracoscopic surgery: a randomized controlled trial Open
Emergence agitation (EA) is more commonly observed after thoracic surgeries and can lead to serious complications. This study aimed to evaluate the effectiveness of serratus anterior plane block (SAPB) combined with oxycodone for transitio…
View article: Macrophage polarization and its impact on idiopathic pulmonary fibrosis
Macrophage polarization and its impact on idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing fibrosis in the lungs and ultimately resulting in respiratory failure and a high risk of death. Macrophages play a crucial role in the immune system, sho…
View article: Characterization of Three Types of Elongases from Different Fungi and Site-Directed Mutagenesis
Characterization of Three Types of Elongases from Different Fungi and Site-Directed Mutagenesis Open
Fatty acid elongases play crucial roles in synthesizing long-chain polyunsaturated fatty acids. Identifying more efficient elongases is essential for enhancing oleaginous microorganisms to produce high yields of target products. We charact…
View article: Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome Open
Metabolic syndrome (MetS) is closely associated with an increased risk of dementia and cognitive impairment, and a complex interaction of genetic and environmental dietary factors may be implicated. Free fatty acid receptor 4 (Ffar4) may b…
View article: miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes [Retraction]
miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes [Retraction] Open
[This retracts the article DOI: 10.2147/JIR.S393646.].
View article: Coastal upwelling and redox variations in the northwestern Tarim Basin (northwest China) during the Middle-Late Ordovician: implication for paleo-depositional conditions of the organic matter enrichment in the Saergan Formation
Coastal upwelling and redox variations in the northwestern Tarim Basin (northwest China) during the Middle-Late Ordovician: implication for paleo-depositional conditions of the organic matter enrichment in the Saergan Formation Open
The black shales of the Saergan Formation, which represent one of the main hydrocarbon source rocks in the Tarim Basin, witnessed a time span of organic matter enrichment by profound changes in the Earth System. A multi-proxy geochemistry …
View article: Identification of PRDX5 as A Target for The Treatment of Castration‐Resistant Prostate Cancer
Identification of PRDX5 as A Target for The Treatment of Castration‐Resistant Prostate Cancer Open
Treatment of castration‐resistant prostate cancer (CRPC) is a long‐standing clinical challenge. Traditionally, CRPC drugs work by either reducing dihydrotestosterone biosynthesis or blocking androgen receptor (AR) signaling. Here it is dem…
View article: Impact of Non-Emergency Surgical Timing on Postoperative Recovery Quality in Mild or Asymptomatic SARS-CoV-2 Infected Patients: A Grouped Cohort Study
Impact of Non-Emergency Surgical Timing on Postoperative Recovery Quality in Mild or Asymptomatic SARS-CoV-2 Infected Patients: A Grouped Cohort Study Open
Objective to explore the relationship between the timing of non-emergency surgery in mild or asymptomatic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infected individuals and the quality of postoperative recovery from the …
View article: T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation
T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation Open
T‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury…
View article: Heavy Li isotopic compositions of the terminal Ediacaran dolostones in the Tarim Basin and their possible link to dolomitizations
Heavy Li isotopic compositions of the terminal Ediacaran dolostones in the Tarim Basin and their possible link to dolomitizations Open
Dolostones are promising archives for recording paleo-seawater Li isotope compositions, and are especially important for the Cambrian and Precambrian periods when limestones are scarce. However, the effect of dolomitization on carbonate Li…
View article: <i>Akkermansia muciniphila</i> supplementation improves glucose tolerance in intestinal <i>Ffar4</i> knockout mice during the daily light to dark transition
<i>Akkermansia muciniphila</i> supplementation improves glucose tolerance in intestinal <i>Ffar4</i> knockout mice during the daily light to dark transition Open
Disruption of blood glucose utilization may lead to diabetes mellitus, which has complex genetic and environmental aspects, and free fatty acid receptors (FFARs) may bridge the genetic and dietary aspects. FFAR4 has been identified as a ne…