Yu Ko
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View article: Comparative effectiveness of minimally invasive therapies for plantar fasciitis: A systematic review and network meta-analysis
Comparative effectiveness of minimally invasive therapies for plantar fasciitis: A systematic review and network meta-analysis Open
Plantar fasciitis is a common and often disabling condition that affects both general and athletic populations, with chronic cases significantly impairing function and quality of life. Although a wide range of conservative and minimally in…
View article: CoPL: Collaborative Preference Learning for Personalizing LLMs
CoPL: Collaborative Preference Learning for Personalizing LLMs Open
Personalizing large language models (LLMs) is important for aligning outputs with diverse user preferences, yet existing methods struggle with flexibility and generalization. We propose CoPL (Collaborative Preference Learning), a graph-bas…
View article: Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real‐World Evidence From Regorafenib and Trifluridine/Tipiracil Use
Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real‐World Evidence From Regorafenib and Trifluridine/Tipiracil Use Open
Objective This study aims to evaluate the real‐world effectiveness and safety of sequential treatment with regorafenib and trifluridine/tipiracil (FTD‐TPI) in patients with metastatic colorectal cancer (mCRC) in Taiwan. Methods Data were o…
View article: CoPL: Collaborative Preference Learning for Personalizing LLMs
CoPL: Collaborative Preference Learning for Personalizing LLMs Open
View article: Effectiveness and Safety of Regorafenib and TAS-102 in Patients with Metastatic Colorectal Cancer: A Nationwide Population-Based Study in Taiwan
Effectiveness and Safety of Regorafenib and TAS-102 in Patients with Metastatic Colorectal Cancer: A Nationwide Population-Based Study in Taiwan Open
Purpose This study aimed to examine the real-world effectiveness and safety of regorafenib and trifluridine/tipiracil (TAS-102) in metastatic colorectal cancer (mCRC) patients in Taiwan.Materials and Methods Data were extracted from Taiwan…
View article: Cost-effectiveness analysis of granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced febrile neutropenia in patients with breast cancer in Taiwan
Cost-effectiveness analysis of granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced febrile neutropenia in patients with breast cancer in Taiwan Open
Objectives To examine the cost-effectiveness of using granulocyte colony-stimulating factor (G-CSF) for primary or secondary prophylaxis in patients with breast cancer from the perspective of Taiwan’s National Health Insurance Administrati…
View article: Prescription patterns of granulocyte colony–stimulating factors in patients with breast cancer: A real-world study
Prescription patterns of granulocyte colony–stimulating factors in patients with breast cancer: A real-world study Open
Background and objectives Myelosuppressive chemotherapy is effective for breast cancer but carries a potential risk of febrile neutropenia (FN). Clinical practice guidelines have recommended prophylaxis with granulocyte colony-stimulating …
View article: Health Utilities of Bilateral Severe-to-Profound Hearing Loss with Assistive Devices
Health Utilities of Bilateral Severe-to-Profound Hearing Loss with Assistive Devices Open
Hearing loss is a common sensory disorder in newborns. Early intervention with assistive devices benefits children’s auditory and speech performance. This study aimed to measure the health utilities of children with bilateral severe-to-pro…
View article: Effectiveness and cost-effectiveness of trastuzumab emtansine in women with HER2-positive locally advanced or metastatic breast cancer
Effectiveness and cost-effectiveness of trastuzumab emtansine in women with HER2-positive locally advanced or metastatic breast cancer Open
Background: Trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor-2 targeted antibody-drug conjugate that contains a monoclonal antibody, trastuzumab, covalently linked to DM1, a small molecule cytotoxin. Methods: We co…
View article: Talent cultivation in health technology assessment: an expert survey
Talent cultivation in health technology assessment: an expert survey Open
View article: An investigation of physicians' prescribing behaviors related to antidiabetic agents for Type 2 diabetes mellitus patients and associated factors in Taiwan
An investigation of physicians' prescribing behaviors related to antidiabetic agents for Type 2 diabetes mellitus patients and associated factors in Taiwan Open
This study aimed to examine the factors that may influence physicians’ choice of antidiabetic agents. In addition, we investigated physicians’ decision-making process and treatment of T2DM patients with chronic kidney disease (CKD). Finall…
View article: Health Utilities in Patients with Type 2 Diabetes in Taiwan
Health Utilities in Patients with Type 2 Diabetes in Taiwan Open
We aimed to measure health utilities in patients with diabetes mellitus (DM) in Taiwan and to estimate the impact of common DM-related complications and adverse effects (AEs) on health utilities. The present study was a cross-sectional sur…
View article: Assessing Knowledge and Attitude of Healthcare Professionals on Biosimilars: A National Survey for Pharmacists and Physicians in Taiwan
Assessing Knowledge and Attitude of Healthcare Professionals on Biosimilars: A National Survey for Pharmacists and Physicians in Taiwan Open
Despite the first approval of biosimilars’ in 2010, biosimilar products usage has remained low in Taiwan. This cross-sectional survey study assessed healthcare professionals’ (HCPs)—hospital pharmacists, oncologists, and rheumatologists—kn…
View article: An evaluation of the healthcare costs of metastatic breast cancer
An evaluation of the healthcare costs of metastatic breast cancer Open
To determine the economic burden of metastatic breast cancer (MBC) in Taiwan, we conducted a national retrospective claim database analysis to evaluate the incremental healthcare costs and utilization of MBC patients as compared to their b…
View article: Effectiveness and healthcare costs of eribulin versus capecitabine among metastatic breast cancer patients in Taiwan
Effectiveness and healthcare costs of eribulin versus capecitabine among metastatic breast cancer patients in Taiwan Open
Although eribulin showed an attenuated effect in the real-world setting in Taiwan, it may serve as an alternative for capecitabine in a heavy pretreated population. The total healthcare and medication costs were found to be higher with eri…
View article: Cardiovascular outcomes and healthcare costs of liraglutide versus basal insulin for type 2 diabetes patients at high cardiovascular risk
Cardiovascular outcomes and healthcare costs of liraglutide versus basal insulin for type 2 diabetes patients at high cardiovascular risk Open
We aimed to compare the (1) clinical outcomes including composite cardiovascular outcomes, cardiovascular death, and all-cause death, and (2) healthcare costs of using liraglutide and basal insulin as an initial treatment for patients with…
View article: Conceptualization, Development and Psychometric Evaluations of a New Medication-Related Health Literacy Instrument: The Chinese Medication Literacy Measurement
Conceptualization, Development and Psychometric Evaluations of a New Medication-Related Health Literacy Instrument: The Chinese Medication Literacy Measurement Open
There is a need for valid and reliable instruments to focus on medication aspects of health literacy and help healthcare professionals address patients’ barriers to medication use. This cross-sectional study describes the conceptualization…
View article: The Misconceptions and Determinants of Diabetes Knowledge in Patients with Diabetes in Taiwan
The Misconceptions and Determinants of Diabetes Knowledge in Patients with Diabetes in Taiwan Open
Aim . This study aimed at (1) examining the misconceptions of patients with diabetes in Taiwan and (2) examining the association between patients’ diabetes knowledge and their demographic characteristics. Methods . A cross-sectional survey…
View article: Costs and length of sepsis-related hospitalizations in Taiwan
Costs and length of sepsis-related hospitalizations in Taiwan Open
To investigate the healthcare expenditures and length of stay (LOS) of sepsis-related hospitalizations in Taiwan. This is a retrospective claim database study. Data were obtained from the two-million-sample longitudinal health and welfare …
View article: Health state utilities for metastatic breast cancer in Taiwan
Health state utilities for metastatic breast cancer in Taiwan Open
This study obtained health state utility values for MBC and grade 3/4 ADRs using both the TTO and the VAS, which provides useful data for future CUAs.
View article: Dataset used in the economic evaluation trastuzumab-based regimens for HER-2 positive metastatic breast cancer patients in the Taiwanese healthcare setting
Dataset used in the economic evaluation trastuzumab-based regimens for HER-2 positive metastatic breast cancer patients in the Taiwanese healthcare setting Open
The present data article aims to describe the input parameters for a Markov model assessing the cost-effectiveness of four treatment sequences for patients with HER-2 positive metastatic breast cancer. The model input parameters include co…
View article: Relationship Between Metformin Use and Lactic Acidosis in Advanced Chronic Kidney Disease: The REMIND-TMU Study
Relationship Between Metformin Use and Lactic Acidosis in Advanced Chronic Kidney Disease: The REMIND-TMU Study Open
View article: Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin
Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin Open
There are significant differences in costs and effectiveness among the second-line treatment options for type 2 diabetes (T2DM). We aimed to evaluate the cost-effectiveness of the second-line anti-diabetic therapy in T2DM patients inadequa…
View article: A cost-effectiveness analysis of trastuzumab-containing treatment sequences for HER-2 positive metastatic breast cancer patients in Taiwan
A cost-effectiveness analysis of trastuzumab-containing treatment sequences for HER-2 positive metastatic breast cancer patients in Taiwan Open
View article: Costs and Length of Stay of Hospitalizations due to Diabetes-Related Complications
Costs and Length of Stay of Hospitalizations due to Diabetes-Related Complications Open
Background . Diabetes mellitus (DM) has become a significant worldwide public health problem and economic burden because a great proportion of healthcare costs has been spent on the treatment of DM and its related complications. The aim of…
View article: Epidemiology of sepsis in Taiwan
Epidemiology of sepsis in Taiwan Open
To investigate the epidemiology trend and characteristics of sepsis-related hospitalizations in Taiwan, and to compare the differences among different severity levels of sepsis. This study is a retrospective national claim database analysi…
View article: Evaluation of the Healthcare Costs and Utilization of Patients with Metastatic Breast Cancer
Evaluation of the Healthcare Costs and Utilization of Patients with Metastatic Breast Cancer Open
View article: Healthcare costs and utilization of diabetes-related complications in Taiwan
Healthcare costs and utilization of diabetes-related complications in Taiwan Open
To estimate the healthcare utilization and costs of major diabetes mellitus (DM)-related complications in Taiwan in the year of first occurrence and in subsequent years.This study is a retrospective claim database analysis using the longit…
View article: Translation, revision, and validation of the Chinese version of the Satisfaction with Oral Anti-Diabetic Agent Scale (C-SOADAS) in patients with type 2 diabetes mellitus
Translation, revision, and validation of the Chinese version of the Satisfaction with Oral Anti-Diabetic Agent Scale (C-SOADAS) in patients with type 2 diabetes mellitus Open
The 5-item C-SOADAS appears to be a psychometrically acceptable measure of OAD treatment satisfaction among type 2 DM patients in Taiwan. The tool may be incorporated into clinical practice to quickly assess treatment outcomes from patient…
View article: Development and validation of a Chinese medication literacy measure
Development and validation of a Chinese medication literacy measure Open
Background Despite the impact of medication literacy ( ML ) on patients’ safe use of medications, existing instruments are mostly for general health literacy measurement or designed for specific disease populations, with few specifically d…