Chenchen Handler
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Cellular mechanical properties in response to environmental viscosity imaged by Brillouin Microscopy Open
An increasing body of research in biomechanics has revealed that the stiffness of the surrounding environment influences cells fate and function. In this context, a recent study showed that cells exposed to highly viscous fluids migrated a…
Macrophages Mediate Mesoscale Brain Mechanical Homeostasis Open
Mechanical cues orchestrate cellular behavior in the brain, yet how they interface with immune regulation remains unresolved. Here, gigahertz‐frequency Brillouin microscopy with optical trap‐based active microrheology is integrated to map …
View article: Stimulated Brillouin scattering flow cytometry
Stimulated Brillouin scattering flow cytometry Open
We present the use of stimulated Brillouin scattering spectroscopy to achieve rapid measurements of cell biomechanics in a flow cytometer setup. Specifically, our stimulated Brillouin scattering flow cytometry can acquire at a rate of 200 …
Macrophage mediated mesoscale brain mechanical homeostasis mechanically imaged via optical tweezers and Brillouin microscopy<i>in vivo</i> Open
Tissues are active materials where epithelial turnover, immune surveillance, and remodeling of stromal cells such as macrophages all regulate form and function. Scattering modalities such as Brillouin microscopy (BM) can non-invasively acc…
Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo Open
Neural tube closure (NTC) is a critical process during embryonic development. Failure in this process can lead to neural tube defects, causing congenital malformations or even mortality. NTC involves a series of mechanisms on genetic, mole…
Time-lapse mechanical imaging of neural tube closure in live embryo using Brillouin microscopy Open
Neural tube closure (NTC) is a complex process of embryonic development involving molecular, cellular, and biomechanical mechanisms. While the genetic factors and biochemical signaling have been extensively investigated, the role of tissue…
Optimal Spin-Up Motion of Wind Turbine using Deterministic Dynamic Programming Open
Due to the depletion of fossil fuels and increasing demand for energy supply, as well as stricter environmental rules and regulations, wind energy has been widely implemented as a renewable energy source. The literature studies various con…
TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer Open
Metastasis is the primary cause of treatment failures and mortality in most cancers. Triple-negative breast cancer (TNBC) is refractory to treatment and rapidly progresses to disseminated disease. We utilized an orthotopic mouse model that…