Chenchen Li
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View article: Atomically engineered nanozymes (AEN): Revolutionizing catalytic immunemodulation for biomedical advances
Atomically engineered nanozymes (AEN): Revolutionizing catalytic immunemodulation for biomedical advances Open
View article: Unveiling the Distinct Effects of a Two-Dimensional Copper/Sodium Complex: Oxidative Stress on Erythrocytes and Cytotoxicity, Apoptosis, Drug Resistance, and Inflammation in Lung Cancer Cells
Unveiling the Distinct Effects of a Two-Dimensional Copper/Sodium Complex: Oxidative Stress on Erythrocytes and Cytotoxicity, Apoptosis, Drug Resistance, and Inflammation in Lung Cancer Cells Open
Introduction: Copper complexes, as endogenous metals, have potential in cancer therapy, addressing issues associated with cisplatin. Since cisplatin uses Copper Transporter 1 (CTR1) for cellular entry, copper complexes may utilize this pat…
View article: Oxygen Vacancy-Engineered Cu2O@CuS p–p Heterojunction Gas Sensor for Highly Sensitive n-Butanol Detection
Oxygen Vacancy-Engineered Cu2O@CuS p–p Heterojunction Gas Sensor for Highly Sensitive n-Butanol Detection Open
The sensitive detection of n-butanol is of high scientific and practical importance for ensuring safety in industrial production. In this study, hollow Cu2O@CuS core–shell nanocubic heterostructures were fabricated via a multistep templati…
View article: Geological Evaluation of In-Situ Pyrolysis Development of Oil-Rich Coal in Tiaohu Mining Area, Santanghu Basin, Xinjiang, China
Geological Evaluation of In-Situ Pyrolysis Development of Oil-Rich Coal in Tiaohu Mining Area, Santanghu Basin, Xinjiang, China Open
The applicability of the in-situ pyrolysis of oil-rich coal is highly dependent on regional geological conditions. In this study, six major geological factors and 19 key parameters influencing the in-situ pyrolysis of oil-rich coal were sy…
View article: Rationally Designed Carbon Nanomaterials for Electrically Driven Solid‐State Hydrogen Storage
Rationally Designed Carbon Nanomaterials for Electrically Driven Solid‐State Hydrogen Storage Open
Non‐dissociative chemisorption for solid‐state hydrogen storage is shown to surpass traditional methods, achieving both high hydrogen capacity and rapid uptake rate. However, current approaches often require low temperatures and high press…
View article: Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine Open
Cancer immunotherapy that activates the stimulator of interferon genes (STING) signaling pathway to resist tumors has recently attracted considerable attention. However, STING activation can induce opposing interferon functions that contri…
View article: High concentrations of fluorescent nanoprobes delayed <i>Oryzias melastigma</i> embryo hatching by modulating respiratory and metabolic pathways
High concentrations of fluorescent nanoprobes delayed <i>Oryzias melastigma</i> embryo hatching by modulating respiratory and metabolic pathways Open
A new graphene‐based fluorescent nanoprobe for tumor cell nucleus (GTTNs) was synthesized in our previous study that penetrates the tumor cell membrane and particularly targets cancer cell nucleus and displays tremendous potential for clin…
View article: Correction: The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
Correction: The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice Open
View article: Longitudinal scRNA-seq of retinal organoids derived from Stargardt disease patient with ABCA4 mutation
Longitudinal scRNA-seq of retinal organoids derived from Stargardt disease patient with ABCA4 mutation Open
Stargardt disease (STGD), predominantly caused by mutations in the ABCA4 gene, is a leading cause of inherited retinal degeneration. Although several lines of mice expressing disease-causing variants have been produced, mice due to the lac…
View article: Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study
Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study Open
Our findings suggested that targeted prevention and early intervention strategies should be implemented to reduce the risk of cancer-related deaths.
View article: Bio-inspired lotus-fiber and mussel-based multifunctional hydrogels for wound healing: super-stretchability, self-healing, adhesion and antibacterial properties
Bio-inspired lotus-fiber and mussel-based multifunctional hydrogels for wound healing: super-stretchability, self-healing, adhesion and antibacterial properties Open
Hydrogel-based wound dressings, which facilitate rapid wound closure and healing, are essential for effective wound management. However, the development of an ideal hydrogel that possesses excellent mechanical properties, effective self-he…
View article: Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe
Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe Open
Maintaining tissue homeostasis necessitates the coordinated efforts of various cell types to regulate inflammation. Endoplasmic reticulum (ER) stress, a hallmark of inflammation, exacerbates tissue pathology in various human diseases. Glut…
View article: Genome-Wide Identification and Analysis of Maize DnaJ Family Genes in Response to Salt, Heat, and Cold at the Seedling Stage
Genome-Wide Identification and Analysis of Maize DnaJ Family Genes in Response to Salt, Heat, and Cold at the Seedling Stage Open
DnaJ proteins, also known as HSP40s, play a key role in plant growth and development, and response to environmental stress. However, little comprehensive research has been conducted on the DnaJ gene family in maize. Here, we identify 91 Zm…
View article: A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform
A dual channel superoxide anion probe for the rapid visualization of scrap leather-induced neuroinflammation using an intramolecular electron transfer-integrated near-infrared platform Open
View article: Animal models, treatment options, and biomaterials for female stress urinary incontinence
Animal models, treatment options, and biomaterials for female stress urinary incontinence Open
In the quest to tackle stress urinary incontinence (SUI), the synthesis of cutting-edge biomaterials and regenerative materials has emerged as a promising frontier. Briefly, animal models like vaginal distension and bilateral ovariectomy s…
View article: Synergistic intravesical instillation for bladder cancer: CRISPR-Cas13a and fenbendazole combination therapy
Synergistic intravesical instillation for bladder cancer: CRISPR-Cas13a and fenbendazole combination therapy Open
Background CRISPR-Cas13a is renowned for its precise and potent RNA editing capabilities in cancer therapy. While various material systems have demonstrated efficacy in supporting CRISPR-Cas13a to execute cellular functions in vitro effici…
View article: A Dopamine‐Modified Hyaluronic Acid‐Based Mucus Carrying Phytoestrogen and Urinary Exosome for Thin Endometrium Repair
A Dopamine‐Modified Hyaluronic Acid‐Based Mucus Carrying Phytoestrogen and Urinary Exosome for Thin Endometrium Repair Open
Thin endometrium (TE) is closely associated with infertility in reproductive medicine. Estrogen therapy gains unsatisfactory outcomes. In this study, an artificial mucus based on dopamine (L‐DOPA)‐modified hyaluronic acid combining phytoes…
View article: The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment
The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment Open
Rheumatoid arthritis (RA) involves chronic joint inflammation. Combining acupuncture and medication for RA treatment faces challenges like spatiotemporal variability, limited drug loading in acupuncture needles, and premature or untargeted…
View article: ROK family regulator NagC promotes prodigiosin biosynthesis independent of <i>N</i> -acetylglucosamine in <i>Serratia</i> sp. ATCC 39006
ROK family regulator NagC promotes prodigiosin biosynthesis independent of <i>N</i> -acetylglucosamine in <i>Serratia</i> sp. ATCC 39006 Open
Serratia sp. ATCC 39006 is an important model strain for the study of prodigiosin production, whose prodigiosin biosynthesis genes ( pigA-O ) are arranged in an operon. Several transcription factors have been shown to control the transcrip…
View article: Functional studies on tandem carbohydrate-binding modules of a multimodular enzyme possessing two catalytic domains
Functional studies on tandem carbohydrate-binding modules of a multimodular enzyme possessing two catalytic domains Open
Although functional studies on carbohydrate-binding module (CBM) have been carried out extensively, the role of tandem CBMs in the enzyme containing multiple catalytic domains (CDs) is unclear. Here, we identified a multidomain enzyme (Lc2…
View article: Research on the mechanism of Guanyu Zhixie Granule in intervening gastric ulcers in rats based on network pharmacology and multi-omics
Research on the mechanism of Guanyu Zhixie Granule in intervening gastric ulcers in rats based on network pharmacology and multi-omics Open
Objective Guanyu Zhixie Granule (GYZXG) is a traditional Chinese medicine compound with definite efficacy in intervening in gastric ulcers (GUs). However, the effect mechanisms on GU are still unclear. This study aimed to explore its mecha…
View article: A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies Open
Splicing factor mutations are common in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but how they alter cellular functions is unclear. We show that the pathogenic SRSF2P95H/+ mutation disrupts the splicing of mitochondr…
View article: Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis
Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis Open
The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the i…
View article: Genetic dissection and identification of stripe rust resistance genes in the wheat cultivar Lanhangxuan 121, a cultivar selected from a space mutation population
Genetic dissection and identification of stripe rust resistance genes in the wheat cultivar Lanhangxuan 121, a cultivar selected from a space mutation population Open
View article: A tightly-coupled LIDAR-IMU SLAM method for quadruped robots
A tightly-coupled LIDAR-IMU SLAM method for quadruped robots Open
Aiming to address the issue of mapping failure resulting from unsmooth motion during SLAM (Simultaneous Localization and Mapping) performed by a quadruped robot, a tightly coupled SLAM algorithm that integrates LIDAR and IMU sensors is pro…
View article: Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications
Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications Open
Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials in catalytic…
View article: Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants
Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants Open
Inherited retinal diseases (IRDs) are a group of common primary retinal degenerative disorders. Conventional genetic testing strategies, such as panel-based sequencing and whole exome sequencing (WES), can only elucidate the genetic etiolo…
View article: Power generation Technology of condensed water Temperature Differences in central air conditioning
Power generation Technology of condensed water Temperature Differences in central air conditioning Open
With the rapid development of modern society, the improvement of people’s requirements for living comfort makes the utilization rate of central air conditioning in civil buildings and industrial plants greatly improved. The research and de…
View article: Lonicerae Japonicae Caulis: a review of its research progress of active metabolites and pharmacological effects
Lonicerae Japonicae Caulis: a review of its research progress of active metabolites and pharmacological effects Open
Lonicerae Japonicae Caulis is the aboveground stem part of the Lonicera Japonica Thunb, which belongs to the medicine food homology species in China. It has the effects of clearing away heat, toxic material, dredging wind and unblocking co…
View article: When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex
When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex Open
The Wnt signaling pathway is a highly conserved regulator of metazoan development and stem cell maintenance. Activation of Wnt signaling is an early step in diverse malignancies. Work over the past four decades has defined a “canonical” Wn…