Chenguang Ding
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View article: HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells
HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells Open
View article: Renal‐targeted exosomes inhibiting <scp>miR</scp>‐182‐5p for treatment of renal ischemia–reperfusion injury
Renal‐targeted exosomes inhibiting <span>miR</span>‐182‐5p for treatment of renal ischemia–reperfusion injury Open
Renal ischemia–reperfusion injury (IRI) is a significant condition that leads to acute kidney injury, exacerbating the progression of renal failure clinically and affecting the patient's prognosis. Following the identification of miR‐182‐5…
View article: Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation
Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation Open
Lyotropic liquid crystalline nanoparticles (LCNPs) have shown significant potential as nanocarriers for antibiotic delivery and as an alternative polytherapy strategy with antibiotics. Mechanistic studies indicate that these nanoparticles …
View article: Advancements in herbal medicine-based nanozymes for biomedical applications
Advancements in herbal medicine-based nanozymes for biomedical applications Open
Nanozymes are a distinct category of nanomaterials that exhibit catalytic properties resembling those of enzymes such as peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Nanozymes derived from…
View article: Honeysuckle‐Derived Carbon Dots With Robust Catalytic and Pharmacological Activities for Mitigating Lung Inflammation by Inhibition of Caspase11/GSDMD‐Dependent Pyroptosis
Honeysuckle‐Derived Carbon Dots With Robust Catalytic and Pharmacological Activities for Mitigating Lung Inflammation by Inhibition of Caspase11/GSDMD‐Dependent Pyroptosis Open
The catalytic activity of carbon dots (CDs) has generated significant interest regarding their potential applications within the biomedical field. However, the structure‐activity relationship of CDs and their pharmacological mechanisms in …
View article: An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4
An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4 Open
Rationale: Ischemia-reperfusion-induced acute kidney injury (IR-AKI), characterized by the abrupt decline in renal function, is distinguished by the intricate interplay between oxidative stress and inflammation. In this study, a rea…
View article: Scutellarin alleviates renal ischemia–reperfusion injury by inhibiting the <scp>MAPK</scp> pathway and pro‐inflammatory macrophage polarization
Scutellarin alleviates renal ischemia–reperfusion injury by inhibiting the <span>MAPK</span> pathway and pro‐inflammatory macrophage polarization Open
Renal ischemia–reperfusion injury (IRI) is an integral process in renal transplantation, which results in compromised graft survival. Macrophages play an important role in both the early inflammatory period and late fibrotic period in resp…
View article: Correction: Development and validation of a novel nomogram model for predicting delayed graft function in deceased donor kidney transplantation based on pre-transplant biopsies
Correction: Development and validation of a novel nomogram model for predicting delayed graft function in deceased donor kidney transplantation based on pre-transplant biopsies Open
View article: Antler blood enhances the ability of stem cell-derived exosomes to promote bone and vascular regeneration
Antler blood enhances the ability of stem cell-derived exosomes to promote bone and vascular regeneration Open
ALB enhances the ability of BMSCs-derived Exos to promote bone and vascular regeneration, which may be related to the up-regulation of miR-21-5p.
View article: Development and validation of a novel nomogram model for predicting delayed graft function in deceased donor kidney transplantation based on pre-transplant biopsies
Development and validation of a novel nomogram model for predicting delayed graft function in deceased donor kidney transplantation based on pre-transplant biopsies Open
Background Delayed graft function (DGF) is an important complication after kidney transplantation surgery. The present study aimed to develop and validate a nomogram for preoperative prediction of DGF on the basis of clinical and histologi…
View article: The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study
The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study Open
Background It has been reported that high blood pressure (HBP) and triglyceride (TG) are considered risk factors in immunoglobulin A nephropathy (IgAN). This study aimed to explore the causalities between HBP and TG, and IgAN on the basis …
View article: Defining the biogeographical map and potential bacterial translocation of microbiome in human ‘surface organs’
Defining the biogeographical map and potential bacterial translocation of microbiome in human ‘surface organs’ Open
View article: Inequalities in Chronic Kidney Disease in Asia: An Updated Meta-Analysis of Age, Sex, and Country
Inequalities in Chronic Kidney Disease in Asia: An Updated Meta-Analysis of Age, Sex, and Country Open
View article: Immune Cell Infiltration is Discriminative for ABMR and TCMR
Immune Cell Infiltration is Discriminative for ABMR and TCMR Open
Antibody-mediated rejection (ABMR) and T cell-mediated rejection (TCMR) are the important causes of kidney transplant failure. Here, we aimed to evaluate the different levels and composition of infiltrating immune cells in kidney allograft…
View article: Knowledge mapping of immunotherapy in castration-resistant prostate cancer: a bibliometric and visualized study (2003–2022)
Knowledge mapping of immunotherapy in castration-resistant prostate cancer: a bibliometric and visualized study (2003–2022) Open
Objective To utilize bibliometric analysis to examine the literature about immunotherapy for castration-resistant prostate cancer published within the past two decades. Through this method, we aim to visualize and analyze the research prog…
View article: Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis
Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis Open
View article: Effect of ureteral stricture in transplant kidney and choice of treatment on long-term graft survival
Effect of ureteral stricture in transplant kidney and choice of treatment on long-term graft survival Open
Background To explore the risk factors of ureteral stricture in transplant kidney and the clinical effects of different treatment methods. Methods The 62 patients with transplant kidney ureteral stenosis as the experimental group, and anot…
View article: Diagnostic and therapeutic strategies for vascular complications after renal transplantation: a single-center experience in 2,304 renal transplantations
Diagnostic and therapeutic strategies for vascular complications after renal transplantation: a single-center experience in 2,304 renal transplantations Open
Vascular complications after renal transplantation are one of the serious surgical complications, which can affect the transplantation outcome and even endanger life if not treated properly. We performed a retrospective analysis of the 2,3…
View article: A multi-center randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients
A multi-center randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients Open
Although the triple immunosuppressive regimen based on calcineurin inhibitors (CNIs) has greatly improved the short-term prognosis of renal transplantation, the long-term prognosis of renal transplantation has not significantly improved. C…
View article: Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species
Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species Open
View article: Postoperative fasting plasma glucose and family history diabetes mellitus can predict post-transplantation diabetes mellitus in kidney transplant recipients
Postoperative fasting plasma glucose and family history diabetes mellitus can predict post-transplantation diabetes mellitus in kidney transplant recipients Open
Purpose To explore whether glycated albumin (GA) or fasting plasma glucose (FPG), both routinely monitored during patients’ hospital stay, can be used to predict post-transplantation diabetes mellitus (PTDM). Methods All kidney transplanta…
View article: Postoperative day 1 serum cystatin C level predicts postoperative delayed graft function after kidney transplantation
Postoperative day 1 serum cystatin C level predicts postoperative delayed graft function after kidney transplantation Open
Background Delayed graft function (DGF) commonly occurs after kidney transplantation, but no clinical predictors for guiding post-transplant management are available. Materials and methods Data including demographics, surgery, anesthesia, …
View article: A randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients
A randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients Open
Background: The calcineurin inhibitor (CNI)-based immune maintenance regimen that is commonly used after renal transplantation has greatly improved early graft survival after transplantation; however, the long-term prognosis of grafts has …
View article: Immune-Related Genes for Predicting Future Kidney Graft Loss: A Study Based on GEO Database
Immune-Related Genes for Predicting Future Kidney Graft Loss: A Study Based on GEO Database Open
Objective We aimed to identify feature immune-related genes that correlated with graft rejection and to develop a prognostic model based on immune-related genes in kidney transplantation. Methods Gene expression profiles were obtained from…
View article: WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway
WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway Open
Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment. This project investigated the regulatory function of WNT1-inducibl…
View article: Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts
Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts Open
Background: The complement system plays an important role in the immune response to transplantation, and the diagnostic significance of peritubular capillary (PTC) C4d deposition (C4d+) in grafts is controversial. The study aimed to fully …
View article: Sustained low‐dose interleukin‐2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus
Sustained low‐dose interleukin‐2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus Open
Objectives Low‐dose interleukin‐2 (IL‐2) has shown promising clinical benefits in the treatment of systemic lupus erythematosus (SLE), but how this therapy alleviates pathogenic humoral immunity remains not well understood. The dilemma is …
View article: Exosomal MicroRNA-374b-5p From Tubular Epithelial Cells Promoted M1 Macrophages Activation and Worsened Renal Ischemia/Reperfusion Injury
Exosomal MicroRNA-374b-5p From Tubular Epithelial Cells Promoted M1 Macrophages Activation and Worsened Renal Ischemia/Reperfusion Injury Open
Tubular epithelial cells (TECs) represent the primary site of renal ischemia/reperfusion injury (RIRI). However, whether the damage of TECs could drive the initiation of inflammation was unclear. Here we investigated the role of the TECs a…
View article: Islet transplantation modulates macrophage to induce immune tolerance and angiogenesis of islet tissue in type I diabetes mice model
Islet transplantation modulates macrophage to induce immune tolerance and angiogenesis of islet tissue in type I diabetes mice model Open
Objective To investigate the dual mechanism of islet transplantation in T1D by regulating the immune tolerance of macrophages and inducing the neovascularization. Methods NC group, T1D model group and T1D model + islet group were construct…
View article: miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury
miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury Open