Chenfei Yu
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View article: Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone
Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone Open
Despite the rapid evolution of therapeutic antibodies, their clinical efficacy in the treatment of bone tumors is hampered due to the inadequate pharmacokinetics and poor bone tissue accessibility of these large macromolecules. Here, we sh…
View article: ZipA Uses a Two-Pronged FtsZ-Binding Mechanism Necessary for Cell Division
ZipA Uses a Two-Pronged FtsZ-Binding Mechanism Necessary for Cell Division Open
The tubulin homolog FtsZ plays a central early role in organizing bacterial cell division proteins at the cytoplasmic membrane. However, FtsZ does not directly interact with the membrane itself, instead relying on proteins such as FtsA to …
View article: Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells
Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells Open
Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing glycans) on target cells. Despite the importance o…
View article: Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone
Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone Open
Therapeutic antibodies have gone a long way toward realizing their clinical potential and have become very useful for treating a variety of pathologies. Despite the rapid evolution of therapeutic antibodies, their clinical efficacy in trea…
View article: Precision Modification of Native Antibodies
Precision Modification of Native Antibodies Open
Antibodies, particularly of the immunoglobulin G (IgG) isotype, are a group of biomolecules that are extensively used as affinity reagents for many applications in research, disease diagnostics, and therapy. Most of these applications requ…
View article: Harnessing the power of antibodies to fight bone metastasis
Harnessing the power of antibodies to fight bone metastasis Open
Precision modification of antibodies with bone-targeting moieties unleashes their potential for the treatment of bone metastases.
View article: Harnessing the Power of Antibodies to Fight Bone Metastasis
Harnessing the Power of Antibodies to Fight Bone Metastasis Open
Over the past 20 years, antibody-based therapies have proved to be of great value in cancer treatment. Despite the clinical success of these biopharmaceuticals, reaching targets in the bone micro-environment has proved to be difficult perh…
View article: Synthesis of Precision Antibody Conjugates Using Proximity-Induced Chemistry
Synthesis of Precision Antibody Conjugates Using Proximity-Induced Chemistry Open
View article: Synthesis of precision antibody conjugates using proximity-induced chemistry
Synthesis of precision antibody conjugates using proximity-induced chemistry Open
Rationale: Therapeutic antibody conjugates allow for the specific delivery of cytotoxic agents or immune cells to tumors, thus enhancing the antitumor activity of these agents and minimizing adverse systemic effects. Most current an…
View article: Site‐Specific Incorporation of a Photoactivatable Fluorescent Amino Acid
Site‐Specific Incorporation of a Photoactivatable Fluorescent Amino Acid Open
Photoactivatable fluorophores are emerging optical probes for biological applications. Most photoactivatable fluorophores are relatively large in size and need to be activated by ultraviolet light; this dramatically limits their applicatio…