Cheng Chen
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View article: Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases
Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases Open
Single-cell multiomics provides critical insights into how disease-associated variants identified through genome-wide association studies (GWASs) influence transcription factor eRegulons within a specific cellular context; however, the reg…
View article: Ultrafast spectroscopic signatures for <i>off</i> -to- <i>on</i> photoswitchable species in a green-to-red photoconvertible fluorescent protein
Ultrafast spectroscopic signatures for <i>off</i> -to- <i>on</i> photoswitchable species in a green-to-red photoconvertible fluorescent protein Open
Ultrafast electronic and Raman spectroscopies on least evolved ancestor (LEA) fluorescent proteins reveal a distorted photoswitched off state returning to on state upon photoexcitation via proton transfer and isomerization, hindering photo…
View article: Internet-delivered cognitive behavioral therapy for insomnia: The future of insomnia treatment with large language models
Internet-delivered cognitive behavioral therapy for insomnia: The future of insomnia treatment with large language models Open
With the rise in the prevalence of insomnia, cognitive behavioral therapy for insomnia (CBT-I) has become an important non-pharmacological approach to the treatment of insomnia patients. Traditional CBT-I faces challenges such as low patie…
View article: Electronic and Steric Tuning of Molecular Acidity toward Unified Models for Excited State Proton Transfer
Electronic and Steric Tuning of Molecular Acidity toward Unified Models for Excited State Proton Transfer Open
Photoinduced proton transfer powers a myriad of functional processes from bioimaging to photocatalysis. However, the elusive structure‐photoacidity and thermodynamics‐kinetics relationships remain the hurdle for developing such useful tool…
View article: Placebo effect of sham acupuncture in patients with insomnia and influence of varying stimulation intensities and locations: A systematic review and meta-analysis
Placebo effect of sham acupuncture in patients with insomnia and influence of varying stimulation intensities and locations: A systematic review and meta-analysis Open
Sham acupuncture produces a measurable and relatively stable placebo effect in insomnia patients. The effectiveness varied across different sham protocols, with low-intensity stimulation and medium-frequency regimens (13-20 sessions) showi…
View article: Disorder‐Induced Targeted Formation of Amorphous Lithium Sulfide for Ah‐Level Lithium–Sulfur Batteries
Disorder‐Induced Targeted Formation of Amorphous Lithium Sulfide for Ah‐Level Lithium–Sulfur Batteries Open
Efficient bidirectional conversion of lithium sulfide (Li 2 S) is of paramount importance for constructing high‐energy‐density lithium–sulfur (Li–S) batteries, but the sluggish reaction kinetics stemming from its intrinsic insulation and a…
View article: A twisted chromophore powers a turn-on fluorescent protein chloride sensor
A twisted chromophore powers a turn-on fluorescent protein chloride sensor Open
Fluorescent proteins (FPs) are noninvasive genetically encodable probes that have revolutionized bioimaging and health fields with vivid images and an ever-growing repertoire from jellyfish to sea anemones and corals. Inside the protein ma…
View article: Morphological and Genetic Characterisation of Seahorse Species (Syngnathidae: Hippocampus spp.) in the Waters of Sabah, Malaysia
Morphological and Genetic Characterisation of Seahorse Species (Syngnathidae: Hippocampus spp.) in the Waters of Sabah, Malaysia Open
Seahorse are teleosts belonging to the genus Hippocampus which consists of 57 species. Among the 57 species, only 12 species exist in Malaysian waters and 11 species in the coastal waters of Sabah. These records and checklists pre-date 201…
View article: Preparation of Cl-Doped g-C3N4 Photocatalyst and Its Photocatalytic Degradation of Rhodamine B
Preparation of Cl-Doped g-C3N4 Photocatalyst and Its Photocatalytic Degradation of Rhodamine B Open
The increasing global demand for clean water is driving the development of advanced wastewater treatment technologies. Graphitic carbon nitride (g-C3N4) has emerged as an efficient photocatalyst for degrading organic pollutants, such as sy…
View article: Potential-dependent interfacial specific adsorption accelerates charge transfer in sodium-ion batteries
Potential-dependent interfacial specific adsorption accelerates charge transfer in sodium-ion batteries Open
Fast-charging capabilities of sodium-ion batteries have emerged as a pivotal objective within the energy storage fields. Sodium layered P2-type oxide cathodes have the most potential for fast charging due to their inherent fast Na+ mobilit…
View article: Microplastics Contamination in Wild Fish Caught from Urbanised Sepanggar River of Kota Kinabalu, Sabah
Microplastics Contamination in Wild Fish Caught from Urbanised Sepanggar River of Kota Kinabalu, Sabah Open
Urban areas with high populations generate high levels of plastic waste from human activities, entering and raising microplastic levels in riverine systems. Microplastic contamination in rivers poses serious risks to fish through ingestion…
View article: Enhanced Reversibility of Iron Metal Anode with a Solid Electrolyte Interphase in Concentrated Chloride Electrolytes
Enhanced Reversibility of Iron Metal Anode with a Solid Electrolyte Interphase in Concentrated Chloride Electrolytes Open
Iron is a promising candidate for a cost‐effective anode for large‐scale energy storage systems due to its natural abundance and well‐established mass production. Recently, Fe‐ion batteries (FeIBs) that use ferrous ions as the charge carri…
View article: Proton Pachinko: Probing Excited‐State Intramolecular Proton Transfer of St. John's Wort‐Derived Fluorescent Photosensitizer Hypericin with Ultrafast Spectroscopy**
Proton Pachinko: Probing Excited‐State Intramolecular Proton Transfer of St. John's Wort‐Derived Fluorescent Photosensitizer Hypericin with Ultrafast Spectroscopy** Open
Hypericin from St. John's wort has been used as a potent photosensitizer, but its working mechanism remains elusive which hinders its rational design for improved functionality. We implement ultrafast spectroscopy and quantum calculations …
View article: Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia
Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia Open
Background and Hypothesis Disorganized thinking is a prominent feature of schizophrenia that becomes persistent in the presence of treatment resistance. Disruption of the default mode network (DMN), which regulates self-referential thinkin…
View article: Meta effect enables redder and larger Stokes shift chromophores by enhanced aromaticity reversal
Meta effect enables redder and larger Stokes shift chromophores by enhanced aromaticity reversal Open
Compact fluorescent molecules with meta-positioned donor (D) and acceptor (A) groups have recently demonstrated extraordinary photophysical properties such as red emission and large Stokes shifts for advanced bioimaging and optoelectronic …
View article: Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases
Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases Open
Advancements in single-cell multimodal techniques have greatly enhanced our understanding of disease-relevant loci identified through genome-wide association studies (GWASs). To investigate the biological connections between the eye and br…
View article: Stabilized Oxygen Vacancy Chemistry toward High-Performance Layered Oxide Cathodes for Sodium-Ion Batteries
Stabilized Oxygen Vacancy Chemistry toward High-Performance Layered Oxide Cathodes for Sodium-Ion Batteries Open
Anionic redox has emerged as a transformative paradigm for high-energy layered transition-metal (TM) oxide cathodes, but it is usually accompanied by the formation of anionic redox-mediated oxygen vacancies (OVs) due to irreversible oxygen…
View article: Developing 1,4-Diethyl-1,2,3,4-tetrahydroquinoxalin-substituted Fluorogens Based on GFP Chromophore for Endoplasmic Reticulum and Lysosome Staining
Developing 1,4-Diethyl-1,2,3,4-tetrahydroquinoxalin-substituted Fluorogens Based on GFP Chromophore for Endoplasmic Reticulum and Lysosome Staining Open
In the present study, we demonstrated that the introduction of a 1,4-diethyl-1,2,3,4-tetrahydroquinoxalin moiety into the arylidene part of GFP chromophore-derived compounds results in the formation of environment-sensitive fluorogens. The…
View article: A Twisted Chromophore that Powers a Fluorescent Protein Chloride Sensor
A Twisted Chromophore that Powers a Fluorescent Protein Chloride Sensor Open
Chromophore nonplanarity and flexibility have long been argued to govern the fluorescence efficiency of fluorescent proteins (FPs), yet their relative importance has been elusive. Herein, we tackle this question by investigating two FP-bas…
View article: Ultrafast planarization of photoexcited ligands in metal–organic frameworks gates charge transfer to promote photocatalysis
Ultrafast planarization of photoexcited ligands in metal–organic frameworks gates charge transfer to promote photocatalysis Open
Metal–organic frameworks (MOFs) have emerged as a highly tunable class of porous materials with wide-ranging applications from gas capture to photocatalysis. Developing these exciting properties to their fullest extent requires a thorough …
View article: Cultural facial expressions dynamically convey emotion category and intensity information
Cultural facial expressions dynamically convey emotion category and intensity information Open
Communicating emotional intensity plays a vital ecological role because it provides valuable information about the nature and likelihood of the sender's behavior.1,2,3 For example, attack often follows signals of intense aggression if rece…
View article: Discovering a Herbicide Terminator: The Role of Metals in Eliminating Glyphosate by Metal-Organic Frameworks
Discovering a Herbicide Terminator: The Role of Metals in Eliminating Glyphosate by Metal-Organic Frameworks Open
The impact of metals within a family of isostructural metal-organic frameworks (MOFs) on the adsorption and photodegradation of the herbicide glyphosate (GP) is presented in this study. Four MOFs, namely Sc-TBAPy, Al-TBAPy, Y-TBAPy, and Fe…
View article: Front Cover: Targeting Ultrafast Spectroscopic Insights into Red Fluorescent Proteins (Chem. Asian J. 20/2023)
Front Cover: Targeting Ultrafast Spectroscopic Insights into Red Fluorescent Proteins (Chem. Asian J. 20/2023) Open
Red fluorescent proteins (RFPs) have powered bioimaging advances in life sciences due to their long-wavelength emissions and reduced phototoxicity. Recent advances in engineering, characterizing, and optimizing several major categories of …
View article: Structural Characterization of Fluorescent Proteins Using Tunable Femtosecond Stimulated Raman Spectroscopy
Structural Characterization of Fluorescent Proteins Using Tunable Femtosecond Stimulated Raman Spectroscopy Open
The versatile functions of fluorescent proteins (FPs) as fluorescence biomarkers depend on their intrinsic chromophores interacting with the protein environment. Besides X-ray crystallography, vibrational spectroscopy represents a highly v…
View article: Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia
Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia Open
Schizophrenia and depression are psychiatric disorders with overlapping clinical and biological features. This study aimed to identify common and distinct neuropathological mechanisms in schizophrenia and depression patients using resting-…
View article: Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila
Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila Open
Severe sleep deprivation (SD) has been highly associated with systemic energy wasting, such as lipid loss and glycogen depletion. Despite immune dysregulation and neurotoxicity observed in SD animals, whether and how the gut-secreted hormo…