Feng Zhang
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View article: CNSC-41. IDENTIFICATION AND VALIDATION OF TRANSITIONAL CEREBELLAR PROGENITORS (TCP) IN THE RHOMBIC LIP OF THE HUMAN FETAL CEREBELLUM
CNSC-41. IDENTIFICATION AND VALIDATION OF TRANSITIONAL CEREBELLAR PROGENITORS (TCP) IN THE RHOMBIC LIP OF THE HUMAN FETAL CEREBELLUM Open
The developing human cerebellum comprises a series of transient progenitor states that are essential for generating diverse neural subtypes, yet the identity and validation of intermediate cell populations bridging stem-like and lineage-co…
View article: VoiceAgentEval: A Dual-Dimensional Benchmark for Expert-Level Intelligent Voice-Agent Evaluation of Xbench's Professional-Aligned Series
VoiceAgentEval: A Dual-Dimensional Benchmark for Expert-Level Intelligent Voice-Agent Evaluation of Xbench's Professional-Aligned Series Open
We propose OutboundEval, a comprehensive benchmark for evaluating large language models (LLMs) in expert-level intelligent outbound calling scenarios. Unlike existing methods that suffer from three key limitations - insufficient dataset di…
View article: Hospital Outcome of Host Heterogeneity, Organ dysfunction and Trajectory in sepsis (HOHHOT): A cohort study in the critical care unit
Hospital Outcome of Host Heterogeneity, Organ dysfunction and Trajectory in sepsis (HOHHOT): A cohort study in the critical care unit Open
Introduction Prognosis estimation is the basis for establishing the personal interventions in sepsis patients. Serum biomarkers are potential tools for predicting the outcomes of sepsis patients admitted to the intensive care unit (ICU). H…
View article: DriftNet: target-area differential attention mechanism for marine drifter trajectory prediction
DriftNet: target-area differential attention mechanism for marine drifter trajectory prediction Open
Recent years have seen the significant potential of Artificial Intelligence (AI) techniques in monitoring and managing ocean ecosystem. Among these, deep learning (DL) solution demonstrated considerable performance in forecasting drifter t…
View article: Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model
Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model Open
View article: Radiofrequency hyperthermia enhances the antitumor efficacy of oncolytic peptide LTX-315 in liver cancer cells by activating of cGAS-STING pathway
Radiofrequency hyperthermia enhances the antitumor efficacy of oncolytic peptide LTX-315 in liver cancer cells by activating of cGAS-STING pathway Open
RFH significantly enhanced the effects of LTX-315 on orthotopic HCC by activating the cGAS-STING pathway.
View article: Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum
Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum Open
The developing human cerebellum comprises a series of transient progenitor states that are essential for generating diverse neural subtypes, yet the identity and validation of intermediate cell populations bridging stem-like and lineage-co…
View article: Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures
Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures Open
Degeneration of the auditory and vestibular hair cells (HCs) leads to dysfunction of two essential senses: hearing loss and decompensated balance perception. However, the cellular and molecular mechanisms governing inner ear aging and its …
View article: Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae
Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae Open
View article: Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae
Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae Open
N6-methyladenosine (m6A) modification pathway is hijacked by several RNA viruses, including SARS-CoV-2, making it an attractive host-directed target for development of broad-spectrum antivirals. Here, we show that histone methyltransferase…
View article: Dynamic regulation of the developmental establishment of the adult hippocampal neural stem cell pool
Dynamic regulation of the developmental establishment of the adult hippocampal neural stem cell pool Open
View article: Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology Open
Current Aβ-targeting therapeutics for Alzheimer's disease (AD) only slow cognitive decline due to poor understanding of AD pathogenesis. Here we describe a mechanism of AD pathogenesis in which the histone methyltransferase G9a noncanonica…
View article: Network analysis and trajectories of maternal emotional symptoms during labor
Network analysis and trajectories of maternal emotional symptoms during labor Open
View article: Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease
Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease Open
Disease-Associated Microglia (DAM) are a focus in Alzheimer's disease (AD) research due to their central involvement in the response to amyloid-beta plaques. Microglial Toll-like receptor 4 (TLR4) is instrumental in the binding of fibrilla…
View article: MMP9<sup>High</sup> Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury
MMP9<sup>High</sup> Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury Open
Neutrophil extracellular traps (NETs) are increasingly recognized as pivotal players and potential therapeutic targets in neutrophil‐mediated reperfusion injury. Despite their importance, the effects and variability of circulating neutroph…
View article: CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling Open
View article: Synthesis and Antitumor Activity of 6-(2-Aminobenzo[<i>d</i>]thiazol-5-yl) quinazolin-4(3<i>H</i>)-one Derivatives
Synthesis and Antitumor Activity of 6-(2-Aminobenzo[<i>d</i>]thiazol-5-yl) quinazolin-4(3<i>H</i>)-one Derivatives Open
Quinazolinones are key scaffolds in anticancer drug development. We previously identified the lead compound 16h from a series of 6-(1H-benzo[d]imidazol-6-yl) quinazolin-4(3H)-one derivatives. In this study, we o…
View article: Advances in neural stem cells in aging and age-related neurodegenerative diseases
Advances in neural stem cells in aging and age-related neurodegenerative diseases Open
With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for prolifera…
View article: Brain-wide neuronal circuit connectome of human glioblastoma
Brain-wide neuronal circuit connectome of human glioblastoma Open
View article: Mitigating Hallucination in Large Vision-Language Models through Aligning Attention Distribution to Information Flow
Mitigating Hallucination in Large Vision-Language Models through Aligning Attention Distribution to Information Flow Open
View article: Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma
Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma Open
Background: Nasopharyngeal carcinoma (NPC) is a highly aggressive malignancy prevalent in Southeast Asia and Southern China, and is characterized by a lack of effective early diagnostic and therapeutic approaches. The 5-year survival rate …
View article: <i>Helicobacter pylori</i>, esophageal precancerous lesions, and proton pump inhibitor overuse
<i>Helicobacter pylori</i>, esophageal precancerous lesions, and proton pump inhibitor overuse Open
This article reviews the cohort study published in the World Journal of Gastroenterology , which reported low rates of Helicobacter pylori (H. pylori ) infection among esophageal cancer (EC) patients, coupled with proton pump inhibitor (PP…
View article: Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation Open
View article: Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice
Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice Open
View article: Efficacy and Safety of <scp><sup>125</sup>I</scp> Seed Implantation in the Treatment of Pelvic Recurrent Cervical Cancer Following Radiotherapy: A Single‐Arm Meta‐Analysis of Chinese Patients
Efficacy and Safety of <span><sup>125</sup>I</span> Seed Implantation in the Treatment of Pelvic Recurrent Cervical Cancer Following Radiotherapy: A Single‐Arm Meta‐Analysis of Chinese Patients Open
Background The study aimed to assess the efficacy and safety of 125 I seed implantation in the treatment of pelvic recurrent cervical cancer following radiotherapy. This meta‐analysis was registered in PROSPERO. We looked up relevant studi…
View article: Spatial distribution and drivers of arbuscular mycorrhizal fungi on the Tibetan Plateau
Spatial distribution and drivers of arbuscular mycorrhizal fungi on the Tibetan Plateau Open
Introduction Arbuscular mycorrhizal fungi (AMF) are pivotal in plant resource acquisition, mediating plant interactions, and influencing soil carbon dynamics. However, their biogeographical distribution in Tibetan alpine grasslands remains…
View article: Preliminary Study on Programmed Cell Death during Calyx Abscission of Korla Fragrant Pear
Preliminary Study on Programmed Cell Death during Calyx Abscission of Korla Fragrant Pear Open
Programmed cell death (PCD) is common in plant growth and development, such as xylem development, organ senescence, and abscission. Calyx abscission in Korla fragrant pear contributes to fruit quality, while it was not clear whether PCD oc…
View article: Identification of the potato (Solanum tuberosum L.) P-type ATPase gene family and investigating the role of PHA2 in response to Pep13
Identification of the potato (Solanum tuberosum L.) P-type ATPase gene family and investigating the role of PHA2 in response to Pep13 Open
P-type ATPase family members play important roles in plant growth and development and are involved in plant resistance to various biotic and abiotic factors. Extensive studies have been conducted on the P-type ATPase gene families in Arabi…
View article: Deep learning‐based magnetic resonance imaging analysis for chronic cerebral hypoperfusion risk
Deep learning‐based magnetic resonance imaging analysis for chronic cerebral hypoperfusion risk Open
Background Chronic cerebral hypoperfusion (CCH) is a frequently encountered clinical condition that poses a diagnostic challenge due to its nonspecific symptoms. Purpose To enhance the diagnosis of CCH and non‐CCH through Magnetic Resonanc…
View article: Graph‐Based Pangenome of <i>Actinidia chinensis</i> Reveals Structural Variations Mediating Fruit Degreening
Graph‐Based Pangenome of <i>Actinidia chinensis</i> Reveals Structural Variations Mediating Fruit Degreening Open
Fruit ripening is associated with the degreening process (loss of chlorophyll) that occurs in most fruit species. Kiwifruit is one of the special species whose fruits may maintain green flesh by accumulating a large amount of chlorophyll e…