Cheng‐Hsien Lu
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View article: Impact of Risk Factors and a New Transfer Pathway on Endovascular Thrombectomy Outcomes in Acute Ischemic Stroke
Impact of Risk Factors and a New Transfer Pathway on Endovascular Thrombectomy Outcomes in Acute Ischemic Stroke Open
The web-based EVT transfer system improved workflow and functional outcomes, highlighting its value even in a small referral cohort.
View article: Muscle Ultrasonography as a Diagnostic Tool for Assessing Sarcopenia in Parkinson’s Disease
Muscle Ultrasonography as a Diagnostic Tool for Assessing Sarcopenia in Parkinson’s Disease Open
Objective This study aimed to evaluate the feasibility of muscle ultrasonography (US) as a diagnostic tool for assessing sarcopenia in patients with Parkinson’s disease (PD) to facilitate early detection and intervention to help prevent fa…
View article: The global burden of stroke attributable to high alcohol use from 1990 to 2021: An analysis for the global burden of disease study 2021
The global burden of stroke attributable to high alcohol use from 1990 to 2021: An analysis for the global burden of disease study 2021 Open
Background Stroke, a leading global cause of death and disability, has high alcohol consumption as a significant modifiable risk factor. Despite the known association, the global spatiotemporal burden and changing relationship between high…
View article: Construction and evaluation of a machine learning-based predictive model for enteral nutrition feeding intolerance risk in ICU patients
Construction and evaluation of a machine learning-based predictive model for enteral nutrition feeding intolerance risk in ICU patients Open
Objective We aim to investigate the factors influencing enteral nutrition feeding intolerance (ENFI) in critically ill patients and develop a risk prediction model for ENFI in intensive care unit (ICU) patients, utilizing three machine lea…
View article: POS0775 RITUXIMAB ASSOCIATED WITH A DECREASED RISK OF LUPUS NEPHRITIS FLARE IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
POS0775 RITUXIMAB ASSOCIATED WITH A DECREASED RISK OF LUPUS NEPHRITIS FLARE IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS Open
View article: Impact of <scp>HbA1c</scp> variability and time‐in‐range fluctuations on large and small nerve fiber dysfunction in well‐controlled type 2 diabetes: A prospective cohort observational study
Impact of <span>HbA1c</span> variability and time‐in‐range fluctuations on large and small nerve fiber dysfunction in well‐controlled type 2 diabetes: A prospective cohort observational study Open
Aims/Introduction Glycemic variability (GV) is a critical factor in the development of diabetic sensorimotor polyneuropathy (DSPN). This study aimed to evaluate the association of long‐term GV, measured by glycated hemoglobin (HbA1c) avera…
View article: Epidemiological trends and forecasts in stroke at global, regional and national levels
Epidemiological trends and forecasts in stroke at global, regional and national levels Open
Despite rising global stroke incidence and DALYs, decreases were seen in ASIR and ASMR since 1990. Incidence rates increased most quickly in females, with regional variation observable. High systolic blood pressure remained a key risk fact…
View article: Shoulder Dysfunction in Parkinson’s Disease: Implications of Motor Subtypes, Disease Severity, and Spinopelvic Alignment
Shoulder Dysfunction in Parkinson’s Disease: Implications of Motor Subtypes, Disease Severity, and Spinopelvic Alignment Open
Objective To investigate shoulder function and muscle alterations in patients with Parkinson’s disease (PD) and determine their associations with spinopelvic parameters and clinical status.Methods This prospective cohort study included 62 …
View article: Radiotherapy Increases Carotid Intima-Media Thickness in Patients with Nasopharyngeal Carcinoma Compared to a Healthy Control Group: A 6-Year Follow-Up Study
Radiotherapy Increases Carotid Intima-Media Thickness in Patients with Nasopharyngeal Carcinoma Compared to a Healthy Control Group: A 6-Year Follow-Up Study Open
Background/Objective: Vascular abnormalities are the primary histological changes in individuals undergoing radiotherapy for nasopharyngeal carcinoma (NPC). We sought to validate the hypothesis that the duration post-radiotherapy is linked…
View article: Assay of Neurodegenerative Biomarkers in Human Plasma of Patients with Parkinson’s Disease
Assay of Neurodegenerative Biomarkers in Human Plasma of Patients with Parkinson’s Disease Open
View article: The Association between the Severity of Distal Sensorimotor Polyneuropathy and Increased Carotid Atherosclerosis in Individuals with Type 2 Diabetes
The Association between the Severity of Distal Sensorimotor Polyneuropathy and Increased Carotid Atherosclerosis in Individuals with Type 2 Diabetes Open
Background: Diabetes contributes to a spectrum of complications encompassing microvascular and macrovascular disorders. This study aimed to explore the correlation between distal sensorimotor polyneuropathy (DSPN) severity and heightened c…
View article: Investigating spatiotemporal and kinematic gait parameters in individuals with Parkinson’s disease with a history of freezing of gait and exploring the effects of dopaminergic therapy on freezing of gait subtypes
Investigating spatiotemporal and kinematic gait parameters in individuals with Parkinson’s disease with a history of freezing of gait and exploring the effects of dopaminergic therapy on freezing of gait subtypes Open
Introduction Freezing of Gait (FOG) is a prevalent and debilitating symptom in idiopathic Parkinson’s disease (PD). This study evaluated spatiotemporal and kinematic gait parameters in individuals with PD with a history of FOG and explored…
View article: Exploring the role of anticipatory postural adjustment duration within APA2 subphase as a potential mediator between clinical disease severity and fall risk in Parkinson’s disease
Exploring the role of anticipatory postural adjustment duration within APA2 subphase as a potential mediator between clinical disease severity and fall risk in Parkinson’s disease Open
Introduction People with Parkinson’s Disease (PD) often show reduced anticipatory postural adjustments (APAs) before voluntary steps, impacting their stability. The specific subphase within the APA stage contributing significantly to fall …
View article: Baroreflex Sensitivity as a Surrogate Biomarker for Concurrently Assessing the Severity of Arterial Stiffness and Cardiovascular Autonomic Neuropathy in Individuals with Type 2 Diabetes
Baroreflex Sensitivity as a Surrogate Biomarker for Concurrently Assessing the Severity of Arterial Stiffness and Cardiovascular Autonomic Neuropathy in Individuals with Type 2 Diabetes Open
This study aimed to investigate whether baroreflex sensitivity (BRS) could serve as a reliable metric for assessing cardiovascular autonomic neuropathy (CAN) and concurrently act as a surrogate biomarker for evaluating the severity of arte…
View article: Prognostic value of longitudinal <scp>HbA1c</scp> variability in predicting the development of diabetic sensorimotor polyneuropathy among patients with type 2 diabetes mellitus: A prospective cohort observational study
Prognostic value of longitudinal <span>HbA1c</span> variability in predicting the development of diabetic sensorimotor polyneuropathy among patients with type 2 diabetes mellitus: A prospective cohort observational study Open
Aims/Introduction This prospective cohort study aims to identify the optimal measure of glycated hemoglobin (HbA1c) variability and to explore its relationship with the development of new diabetic sensorimotor polyneuropathy (DSPN) in indi…
View article: The clinical characteristics and therapeutic outcomes of adult patients with community-acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan
The clinical characteristics and therapeutic outcomes of adult patients with community-acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan Open
View article: Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes
Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes Open
Existing evidence supports an association between chemerin levels and cardiovascular risk, while reduced thiol levels are linked to diabetes mellitus. It is hypothesized that chemerin may contribute to autonomic dysfunction and cardiovascu…
View article: Editorial: Diabetic neuropathy and its complications
Editorial: Diabetic neuropathy and its complications Open
EDITORIAL article Front. Neurosci., 14 August 2023Sec. Neuroendocrine Science Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1267417
View article: The clinical characteristics and therapeutic outcomes of adult patients with community- acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan
The clinical characteristics and therapeutic outcomes of adult patients with community- acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan Open
Purpose To examine the clinical characteristics of adult patients with community-acquired spontaneous bacterial meningitis (CASBM) with a fulminant clinical course. Material and methods The clinical features and therapeutic outcomes of 127…
View article: A high-efficiency, reliable multilevel hardware-accelerated annealer with in-memory spin coupling and complementary read algorithm
A high-efficiency, reliable multilevel hardware-accelerated annealer with in-memory spin coupling and complementary read algorithm Open
We proposed an in-memory spin coupler based on the 55 nm NOR flash technology to tackle the combinatorial optimization problems. The high-density and cost-effective floating-gate (FG) devices can overcome the capacity limitation in the con…
View article: Assessing the Feasibility of Using Electrochemical Skin Conductance as a Substitute for the Quantitative Sudomotor Axon Reflex Test in the Composite Autonomic Scoring Scale and Its Correlation with Composite Autonomic Symptom Scale 31 in Parkinson’s Disease
Assessing the Feasibility of Using Electrochemical Skin Conductance as a Substitute for the Quantitative Sudomotor Axon Reflex Test in the Composite Autonomic Scoring Scale and Its Correlation with Composite Autonomic Symptom Scale 31 in Parkinson’s Disease Open
The Composite Autonomic Scoring Scale (CASS) is a quantitative scoring system that integrates the sudomotor, the cardiovagal, and the adrenergic subscores, and the Composite Autonomic Symptom Scale 31 (COMPASS 31) is based on a well-establ…
View article: Electroencephalogram-Driven Machine-Learning Scenario for Assessing Impulse Control Disorder Comorbidity in Parkinson’s Disease Using a Low-Cost, Custom LEGO-Like Headset
Electroencephalogram-Driven Machine-Learning Scenario for Assessing Impulse Control Disorder Comorbidity in Parkinson’s Disease Using a Low-Cost, Custom LEGO-Like Headset Open
Patients with Parkinson's disease (PD) may develop cognitive symptoms of impulse control disorders (ICDs) when chronically treated with dopamine agonist (DA) therapy for motor deficits. Motor and cognitive comorbidities critically increase…
View article: Feasibility of Combining Disease-Specific and Balance-Related Measures as Risk Predictors of Future Falls in Patients with Parkinson’s Disease
Feasibility of Combining Disease-Specific and Balance-Related Measures as Risk Predictors of Future Falls in Patients with Parkinson’s Disease Open
Evidence supports the view that postural sway in a quiet stance increases with clinical disease severity and dopaminergic therapy in idiopathic Parkinson’s disease (PD), which, in turn, increases the risk of falling. This study evaluated t…
View article: The Effects of Indoxyl Sulfate and Oxidative Stress on the Severity of Peripheral Nerve Dysfunction in Patients with Chronic Kidney Diseases
The Effects of Indoxyl Sulfate and Oxidative Stress on the Severity of Peripheral Nerve Dysfunction in Patients with Chronic Kidney Diseases Open
Pieces of evidence support the view that the accumulation of uremic toxins enhances oxidative stress and downstream regulation of signaling pathways, contributing to both endothelial microangiography and cell dysfunction. This study is to …
View article: Relevance of plasma biomarkers to pathologies in Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia
Relevance of plasma biomarkers to pathologies in Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia Open
Amyloid plaques and tau tangles are pathological hallmarks of Alzheimer’s disease (AD). Parkinson’s disease (PD) results from the accumulation of α-synuclein. TAR DNA-binding protein (TDP-43) and total tau protein (T-Tau) play roles in FTD…
View article: Increased Levels of Plasma Alzheimer’s Disease Biomarkers and Their Associations with Brain Structural Changes and Carotid Intima-Media Thickness in Cognitively Normal Obstructive Sleep Apnea Patients
Increased Levels of Plasma Alzheimer’s Disease Biomarkers and Their Associations with Brain Structural Changes and Carotid Intima-Media Thickness in Cognitively Normal Obstructive Sleep Apnea Patients Open
Obstructive sleep apnea (OSA) has been linked to Alzheimer’s disease (AD) and amyloid deposition in the brain. OSA is further linked to the development of cardiovascular and cerebrovascular diseases. In this study, we analyzed the plasma l…
View article: Radiotherapy Is Associated with an Accelerated Risk of Carotid Atherosclerosis in Patients with Nasopharyngeal Carcinoma: A Nine-Year Prospective Follow-Up Study
Radiotherapy Is Associated with an Accelerated Risk of Carotid Atherosclerosis in Patients with Nasopharyngeal Carcinoma: A Nine-Year Prospective Follow-Up Study Open
Radiation-related extracranial vasculopathy is a common late effect after radiation in patients with nasopharyngeal carcinoma (NPC). We proposed the hypothesis that radiation-related extracranial vasculopathy is a progressive process that …
View article: Effectiveness of Different Methods for Baroreflex Sensitivity Assessment in Determining the Severity of Cardiovascular Autonomic Neuropathy in Patients With Parkinson’s Disease
Effectiveness of Different Methods for Baroreflex Sensitivity Assessment in Determining the Severity of Cardiovascular Autonomic Neuropathy in Patients With Parkinson’s Disease Open
Background Autonomic disorders are an important non-motor feature of Parkinson’s disease (PD). Baroreflex sensitivity (BRS) is often used as an indicator of cardiovascular autonomic function, and it is clinically significant. Several diffe…
View article: Clinical Disease Severity Mediates the Relationship between Stride Length and Speed and the Risk of Falling in Parkinson’s Disease
Clinical Disease Severity Mediates the Relationship between Stride Length and Speed and the Risk of Falling in Parkinson’s Disease Open
The shuffling gait with slowed speed and reduced stride length has been considered classic clinical features in idiopathic Parkinson’s disease (PD), and the risk of falling increases as the disease progresses. This raises the possibility t…
View article: Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects
Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects Open
Subjects with comorbidities are at risk for neurodegeneration. There is a lack of a direct relationship between comorbidities and neurodegeneration. In this study, immunomagnetic reduction (IMR) assays were utilized to assay plasma Aβ 1–42…