Cheng‐Hung Lin
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View article: Unraveling the Roles of Macrophages in Vascularized Composite Allotransplantation
Unraveling the Roles of Macrophages in Vascularized Composite Allotransplantation Open
The phenotypic heterogeneity and functional diversity of macrophages have been increasingly appreciated, particularly regarding their roles as innate immune cells in shaping transplantation outcomes. However, their functions in vascularize…
View article: Roux-en-Y gastric bypass, adjustable gastric banding, or sleeve gastrectomy for severe obesity (By-Band-Sleeve): a multicentre, open label, three-group, randomised controlled trial
Roux-en-Y gastric bypass, adjustable gastric banding, or sleeve gastrectomy for severe obesity (By-Band-Sleeve): a multicentre, open label, three-group, randomised controlled trial Open
National Institute for Health and Care Research Health Technology Assessment Programme.
View article: Comparing Surgical Approaches for Thumb Polydactyly Reconstruction in Wassel Type IV: K-wire Fixation Versus Non-K-wire Fixation
Comparing Surgical Approaches for Thumb Polydactyly Reconstruction in Wassel Type IV: K-wire Fixation Versus Non-K-wire Fixation Open
Background: Wassel type IV is a common radial polydactyly anomaly characterized by duplication of the proximal phalanges at the metacarpophalangeal joint (MPJ). The primary goal of reconstructive surgery is to achieve a fully functional th…
View article: Effectiveness and safety of negative pressure wound therapy in patients with deep sternal wound infection: a systematic review and meta-analysis
Effectiveness and safety of negative pressure wound therapy in patients with deep sternal wound infection: a systematic review and meta-analysis Open
Background: Deep sternal wound infection (DSWI) is a severe and life-threatening complication following cardiovascular surgery. Negative pressure wound therapy (NPWT) has emerged as a promising therapeutic bridging option for DSWI. In this…
View article: Supercharge end-to-side nerve transfer from anterior interosseous nerve to augment intrinsic recovery in high ulnar nerve injuries of varying magnitudes
Supercharge end-to-side nerve transfer from anterior interosseous nerve to augment intrinsic recovery in high ulnar nerve injuries of varying magnitudes Open
Our findings suggest that SETS AIN transfer benefits patients with high ulnar nerve palsy, regardless of the lesion type. Nonetheless, improvements may be more pronounced in patients with transected lesions.
View article: Exploring the Role of Free Tissue Transfers in the Preservation of Bone Length and Knee Joint Function after Lower Limb Trauma: A Retrospective Analysis
Exploring the Role of Free Tissue Transfers in the Preservation of Bone Length and Knee Joint Function after Lower Limb Trauma: A Retrospective Analysis Open
Lower limb trauma often results in mangled extremities, and in some cases, complete amputation may be necessary. However, limiting the extent of amputation and preserving the major knee joint are crucial to enhance mobility and overall fun…
View article: Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells by Hydrogel Encapsulation
Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells by Hydrogel Encapsulation Open
Mesenchymal stromal cells (MSCs) showcase remarkable immunoregulatory capabilities in vitro, positioning them as promising candidates for cellular therapeutics. However, the process of administering MSCs and the dynamic in vivo environment…
View article: Predicting Union, Osteomyelitis, and Amputation Outcomes of Gustilo <scp>IIIC</scp> Open Tibial Fractures: A Retrospective Study
Predicting Union, Osteomyelitis, and Amputation Outcomes of Gustilo <span>IIIC</span> Open Tibial Fractures: A Retrospective Study Open
Objective Open tibial fractures are frequently encountered in high‐energy traumas and can result in significant complications such as nonunion, osteomyelitis, and even amputation. Among open tibial fractures, Gustilo type IIIC cases are pa…
View article: Stack versus Te Technique for Central Slip Reconstruction during Vascularized Toe Proximal Interphalangeal Joint Transfer
Stack versus Te Technique for Central Slip Reconstruction during Vascularized Toe Proximal Interphalangeal Joint Transfer Open
Background: Significant extension deficit is a common problem after a vascularized toe proximal interphalangeal joint transfer. One of the main causes related to extensor lag is central slip deficiency of the donor toes. In their clinical …
View article: Vascularized Toe Proximal Interphalangeal Joint Transfer in Posttraumatic Fingers: Analysis of Prognostic Factors for Suboptimal Outcomes
Vascularized Toe Proximal Interphalangeal Joint Transfer in Posttraumatic Fingers: Analysis of Prognostic Factors for Suboptimal Outcomes Open
Background: Posttraumatic finger osteoarthritis of the proximal interphalangeal joint (PIPJ) is a difficult problem. Over the past decade, we have reported several methods for improving the outcomes of vascularized toe joint transfer (VJT)…
View article: Comparison of Innervated and Non-innervated Free Glabrous Skin Flap Transfers for Volar Digital Defect Reconstructions - A patient-reported Outcome Study
Comparison of Innervated and Non-innervated Free Glabrous Skin Flap Transfers for Volar Digital Defect Reconstructions - A patient-reported Outcome Study Open
Soft tissue defects of the volar digits can be challenging to reconstruct. Toe pulp flaps and medialis pedis flaps are two commonly used flaps for volar digital soft tissue reconstruction, each with its advantages and disadvantages. Toe pu…
View article: Lambda Repair: A Novel Repair Technique for Chronic Boutonnière Deformity
Lambda Repair: A Novel Repair Technique for Chronic Boutonnière Deformity Open
Summary: Correction of a boutonnière deformity is one of the most demanding challenges in hand surgery. Surgical interventions are usually considered when functional use of the finger cannot be obtained after intense hand therapy. The auth…
View article: Toward transplantation tolerance with adipose tissue-derived therapeutics
Toward transplantation tolerance with adipose tissue-derived therapeutics Open
Solid organ and composite tissue allotransplanation have been widely applied to treat end-stage organ failure and massive tissue defects, respectively. Currently there are a lot of research endeavors focusing on induction of transplantatio…
View article: Incidence and Risk Factors for Extremity Osteoradionecrosis after Limb-Sparing Surgery and Adjuvant Radiotherapy
Incidence and Risk Factors for Extremity Osteoradionecrosis after Limb-Sparing Surgery and Adjuvant Radiotherapy Open
Osteoradionecrosis (ORN) is a major complication after radiotherapy. Most studies on ORN have focused on patients with mandibular lesions, with few studies including patients with extremity soft tissue sarcoma (STS). We included 198 patien…
View article: Fine-grained Visual Classification with High-temperature Refinement and Background Suppression
Fine-grained Visual Classification with High-temperature Refinement and Background Suppression Open
Fine-grained visual classification is a challenging task due to the high similarity between categories and distinct differences among data within one single category. To address the challenges, previous strategies have focused on localizin…
View article: Donor derived hematopoietic stem cell niche transplantation facilitates mixed chimerism mediated donor specific tolerance
Donor derived hematopoietic stem cell niche transplantation facilitates mixed chimerism mediated donor specific tolerance Open
Compelling experimental evidence confirms that the robustness and longevity of mixed chimerism (MC) relies on the persistence and availability of donor-derived hematopoietic stem cell (HSC) niches in recipients. Based on our prior work in …
View article: Heterotopic Digital Replantation in Mutilating Hand Injuries: An Algorithmic Approach Based on 53 Cases and Literature Review
Heterotopic Digital Replantation in Mutilating Hand Injuries: An Algorithmic Approach Based on 53 Cases and Literature Review Open
Background Reconstruction of the mutilated hand is one of the most difficult challenges for hand microsurgeons. When multiple digits are amputated, orthotopic digital replantation of the available remnants may not adequately restore the ha…
View article: Comparative outcomes between surgical treatment and orthosis splint for mallet finger: a systematic review and meta-analysis
Comparative outcomes between surgical treatment and orthosis splint for mallet finger: a systematic review and meta-analysis Open
Mallet finger is a commonly encountered condition in daily practice. However, there is currently no consensus on whether surgical intervention or conservative treatment with orthosis splint is superior. In this systematic review and meta-a…
View article: Predicting union, osteomyelitis, and amputation outcomes of open type IIIC tibial fractures: A retrospective study
Predicting union, osteomyelitis, and amputation outcomes of open type IIIC tibial fractures: A retrospective study Open
Background: We aimed to assess the factors that affect union time and complications in IIIC (based on the Gustilo classification) tibial fractures. Materials and Methods: This retrospective analysis included patients with IIIC open tibial …
View article: The intragraft vascularized bone marrow induces secondary donor-specific mystacial pad allograft tolerance
The intragraft vascularized bone marrow induces secondary donor-specific mystacial pad allograft tolerance Open
Introduction Vascularized bone marrow (VBM) is essential in tolerance induction through chimerism. We hypothesized that the inclusion of VBM contributes to the induction of mystacial pad allotransplantation tolerance. Method In this study,…
View article: Comparison of the clinical outcomes between vascularized bone graft and the Masquelet technique for the reconstruction of Gustilo type III open tibial fractures
Comparison of the clinical outcomes between vascularized bone graft and the Masquelet technique for the reconstruction of Gustilo type III open tibial fractures Open
Background Gustilo type III tibial fractures commonly involve extensive soft tissue and bony defects, requiring complex reconstructive operations. Although several methods have been proposed, no research has elucidated the efficacies and d…
View article: Nutritional support for successful weaning in patients undergoing prolonged mechanical ventilation
Nutritional support for successful weaning in patients undergoing prolonged mechanical ventilation Open
Successful weaning from ventilators not only improves the quality of life of patients, but also reduces medical expenses. The aim of this study was to explore the association between nutritional provision and successful ventilator weaning.…
View article: Association of General Anesthesia and Neuraxial Anesthesia in Caesarean Section with Maternal Postpartum Depression: A Retrospective Nationwide Population-Based Cohort Study
Association of General Anesthesia and Neuraxial Anesthesia in Caesarean Section with Maternal Postpartum Depression: A Retrospective Nationwide Population-Based Cohort Study Open
Although cesarean section (CS) has become a common method of child delivery in recent decades, the choice between general anesthesia (GA) and neuraxial anesthesia (NA) for CS must be carefully considered. Depending on the type of anesthesi…
View article: Comparison of the effectiveness of local anesthesia for the digital block between single-volar subcutaneous and double-dorsal finger injections: a systematic review and meta-analysis of randomized control trials
Comparison of the effectiveness of local anesthesia for the digital block between single-volar subcutaneous and double-dorsal finger injections: a systematic review and meta-analysis of randomized control trials Open
Local anesthesia is an effective method to perform digital nerve blocks. In this study, we compare the effectiveness of single-volar subcutaneous and double-dorsal injection through a systematic review and meta-analysis of randomized contr…
View article: Predicting the outcome of open type IIIC tibial fractures regarding union, osteomyelitis, and amputation: A retrospective study
Predicting the outcome of open type IIIC tibial fractures regarding union, osteomyelitis, and amputation: A retrospective study Open
Background This study aimed to assess factors that affect union time and complications in Gustilo IIIC tibial fractures. Methods This retrospective analysis included patients with IIIC open tibial fractures who visited our center from Janu…
View article: Prospective outcome analysis of ulnar tunnel syndrome: Comparing traumatic versus non-traumatic etiologies
Prospective outcome analysis of ulnar tunnel syndrome: Comparing traumatic versus non-traumatic etiologies Open
Ulnar tunnel release improves the outcome of patients regardless of the etiology, especially in patients with trauma-induced UTS. Thus, a proper diagnosis of the UTS should be alerted in all patients encountering paresthesia in the ulnar d…
View article: A Novel Plug-in Module for Fine-Grained Visual Classification
A Novel Plug-in Module for Fine-Grained Visual Classification Open
Visual classification can be divided into coarse-grained and fine-grained classification. Coarse-grained classification represents categories with a large degree of dissimilarity, such as the classification of cats and dogs, while fine-gra…
View article: Implantable Immunosuppressant Delivery to Prevent Rejection in Transplantation
Implantable Immunosuppressant Delivery to Prevent Rejection in Transplantation Open
An innovative immunosuppressant with a minimally invasive delivery system has emerged in the biomedical field. The application of biodegradable and biocompatible polymer forms, such as hydrogels, scaffolds, microspheres, and nanoparticles,…
View article: Cell therapy in vascularized composite allotransplantation
Cell therapy in vascularized composite allotransplantation Open
View article: Predicting the Outcome of Open Type IIIC Tibial Fractures Regarding Union, Osteomyelitis, and Amputation
Predicting the Outcome of Open Type IIIC Tibial Fractures Regarding Union, Osteomyelitis, and Amputation Open
Backgrounds: This study aimed to assess factors that affect union time and complications in Gustilo IIIC tibial fractures. Methods: Patients who presented to our center with IIIC open tibial fractures from January 2000 to October 2020 were…