Maosheng Cheng
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View article: Dispersion‐Enhanced Nitrogen‐Centered Photocatalysis of the Direct Hydrogen Atom Transfer
Dispersion‐Enhanced Nitrogen‐Centered Photocatalysis of the Direct Hydrogen Atom Transfer Open
The development of structurally distinct and modular photocatalysts for direct hydrogen atom transfer (HAT) has emerged as a key frontier in radical‐mediated C–H functionalization of strong carbon–hydrogen bonds. Despite the largely untapp…
View article: Dispersion‐Enhanced Nitrogen‐Centered Photocatalysis of the Direct Hydrogen Atom Transfer
Dispersion‐Enhanced Nitrogen‐Centered Photocatalysis of the Direct Hydrogen Atom Transfer Open
The development of structurally distinct and modular photocatalysts for direct hydrogen atom transfer (HAT) has emerged as a key frontier in radical‐mediated C–H functionalization of strong carbon–hydrogen bonds. Despite the largely untapp…
View article: Pathway economy in cyclization of 1 <i>,n</i> -enynes
Pathway economy in cyclization of 1 <i>,n</i> -enynes Open
This review presents a paradigm-shifting "pathway economy" strategy for 1, n -enyne cyclization, enabling divergent construction of complex molecular architectures from a single substrate class. Through mechanistic-guided modulation of cat…
View article: Patient’s knowledge, attitudes and behaviours towards pulmonary nodule management: a cross-sectional study in Wenzhou, China
Patient’s knowledge, attitudes and behaviours towards pulmonary nodule management: a cross-sectional study in Wenzhou, China Open
Objectives The prevalence of pulmonary nodules (PNs) has been rising in China, but PN patients’ perceptions towards the management remain underexplored. This study aimed to investigate the knowledge, attitudes and behaviours (KAB) regardin…
View article: Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors” [Acta Pharm Sin B 12 (2022) 952–966]
Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors” [Acta Pharm Sin B 12 (2022) 952–966] Open
[This corrects the article DOI: 10.1016/j.apsb.2021.08.008.].
View article: Design, Synthesis, and Computational Insights into PKMYT1 Inhibitors for the Treatment of Breast Cancer
Design, Synthesis, and Computational Insights into PKMYT1 Inhibitors for the Treatment of Breast Cancer Open
Background: Membrane-associated tyrosine-threonine protein kinase 1 (PKMYT1), which is identified as a synthetic lethal partner of CCNE1, emerged as a promising therapeutic target in oncology. Methods: A series of novel PKMYT1 inhibitors w…
View article: [Retracted] (‑)‑β‑hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity
[Retracted] (‑)‑β‑hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Open
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the flow cytometric data shown in Fig. 4A and Transwell cell migration and invasion assay data in Fig. 6A subsequently ap…
View article: PCIF1 drives oesophageal squamous cell carcinoma progression via m6Am‐mediated suppression of MTF2 translation
PCIF1 drives oesophageal squamous cell carcinoma progression via m6Am‐mediated suppression of MTF2 translation Open
Oesophageal squamous cell carcinoma (OSCC) represents a highly aggressive malignancy with limited therapeutic options and poor prognosis. This study uncovers PCIF1 as a critical driver of OSCC progression via m6Am RNA modification, leading…
View article: Panax notoginseng improves the sensitivity of non-small cell lung cancer to cisplatin by inhibiting Akt signaling
Panax notoginseng improves the sensitivity of non-small cell lung cancer to cisplatin by inhibiting Akt signaling Open
Background Cisplatin (DDP) resistance is a major challenge in the management of non-small cell lung cancer (NSCLC). Panax notoginseng has anticancer effects on a variety of solid tumors, but data on NSCLC and DDP resistance are lacking. Ob…
View article: Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors
Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors Open
Serine/threonine kinase PLK4, a critical regulator of centrosome duplication, is closely associated with tumorigenesis due to its role in centrosome amplification.
View article: Mild synthesis of fused polycyclic 1,6-naphthyridin-4-amines and their optical properties
Mild synthesis of fused polycyclic 1,6-naphthyridin-4-amines and their optical properties Open
We have successfully developed a straightforward route to tri-, tetra-, and pentacyclic 1,6-naphthyridin-4-amines through intramolecular cyclisation of 4-(arylamino)nicotinonitriles, and their fluorescent properties were studied.
View article: Design, synthesis and antitumor activity evaluation of novel IMPDH II and HDAC1 dual inhibitor
Design, synthesis and antitumor activity evaluation of novel IMPDH II and HDAC1 dual inhibitor Open
A novel dual inhibitor targeting IMPDH II and HDAC1.
View article: Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains
Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains Open
We've found a novel class of amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains and evaluated the antifungal mechanism of the preferred compound B3.
View article: Design, synthesis, and biological evaluation of 2-phenylthiazole CYP51 inhibitors
Design, synthesis, and biological evaluation of 2-phenylthiazole CYP51 inhibitors Open
Overall design idea of new 2-phenylthiazole CYP51 inhibitors.
View article: Discovery of new imidazole[1,2-<i>a</i>] pyridine derivatives as CDK9 inhibitors: design, synthesis and biological evaluation
Discovery of new imidazole[1,2-<i>a</i>] pyridine derivatives as CDK9 inhibitors: design, synthesis and biological evaluation Open
A promising highly selective CDK9 inhibitor LB-1, with an imidazole[1,2- a ] pyridine framework, was discovered for treatment of colorectal cancer.
View article: Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470
Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470 Open
In the original publication [...]
View article: Scalable Synthesis of the Key Fexuprazan Intermediate and Investigation of a Reaction Mechanism
Scalable Synthesis of the Key Fexuprazan Intermediate and Investigation of a Reaction Mechanism Open
A three-step method for the synthesis of methyl 5-(2,4-difluorophenyl)-4-methoxy-1H-pyrrole-3-carboxylate 1, a key intermediate of fexuprazan, is reported in this paper. Using low-priced sodium p-tolylsulfinate as the starting material, co…
View article: ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4+ macrophage infiltration
ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4+ macrophage infiltration Open
Enoblituzumab, an immunotherapeutic agent targeting CD276, shows both safety and efficacy in activating T cells and oligodendrocyte-like cells against various cancers. Preclinical studies and mouse models suggest that therapies targeting C…
View article: Identification of a Novel Selective CDK9 Inhibitor for the Treatment of CRC: Design, Synthesis, and Biological Activity Evaluation
Identification of a Novel Selective CDK9 Inhibitor for the Treatment of CRC: Design, Synthesis, and Biological Activity Evaluation Open
Cyclin-dependent kinase 9 (CDK9) is a member of the transcription CDK subfamily. In this work, we preliminarily demonstrated the feasibility of CDK9 as a potent target of treatment for colorectal cancer, and a series of novel CDK9 inhibito…
View article: Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety
Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety Open
A series of novel echinatin derivatives with 1,3,4-oxadiazole moieties were designed and synthesized. Most of the newly synthesized compounds exhibited moderate antiproliferative activity against the four cancer cell lines. Notably, Compou…