Shaokoon Cheng
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View article: Optimizing topical delivery to the ostiomeatal complex after functional endoscopic sinus surgery using a bidirectional delivery method
Optimizing topical delivery to the ostiomeatal complex after functional endoscopic sinus surgery using a bidirectional delivery method Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a therapeutic challenge due to frequent recurrence after surgery, largely stemming from inadequate drug delivery to the posterior nasal mucosa, particularly the ostiomeatal complex …
View article: A new method for simultaneous measurement of droplet or particle surface area and velocity
A new method for simultaneous measurement of droplet or particle surface area and velocity Open
View article: Characterizing the time dependent deposition of particles in a channel flow using optical coherence tomography
Characterizing the time dependent deposition of particles in a channel flow using optical coherence tomography Open
View article: Age-related anatomical variations and the impact of adenoid hypertrophy on nasal airflow in Asian children
Age-related anatomical variations and the impact of adenoid hypertrophy on nasal airflow in Asian children Open
View article: Microfluidic Femtosecond Laser-Induced Nucleation of Supersaturated Aqueous Sodium Chlorate Solutions
Microfluidic Femtosecond Laser-Induced Nucleation of Supersaturated Aqueous Sodium Chlorate Solutions Open
Femtosecond laser-induced crystallization has gained significant attention due to its precise control over crystal formation in recent years; however, challenges remain in improving the efficiency and consistency of this process. Another e…
View article: Experimental measurements of particle deposition in the human nasal airway
Experimental measurements of particle deposition in the human nasal airway Open
Intranasal drug delivery is a promising non-invasive method for administering both local and systemic medications. While previous studies have extensively investigated the effects of particle size, airflow dynamics, and deposition location…
View article: Numerical investigation of the impact of saber-sheath trachea severity on microparticle deposition in the lower respiratory airway
Numerical investigation of the impact of saber-sheath trachea severity on microparticle deposition in the lower respiratory airway Open
View article: Computational study of the impact of nasal vestibule anatomy on nasal drug administration with nasal spray
Computational study of the impact of nasal vestibule anatomy on nasal drug administration with nasal spray Open
The nasal airway comprises a complex network of passages and chambers and plays an important role in regulating the respiratory system's functions. The nasal vestibule is the first chamber of the nasal airway. While variations in nasal ves…
View article: Advances in the management of arteriosclerosis of the lower extremity: Integrating Western and Chinese medicine approaches
Advances in the management of arteriosclerosis of the lower extremity: Integrating Western and Chinese medicine approaches Open
This editorial provides a commentary on the recent article. The paper reviews current literature and explores innovative treatment strategies for lower extremity arteriosclerosis obliterans (LEASO) through an integrative approach. It highl…
View article: Deep reinforcement learning and mesh deformation integration for shape optimization of a single pin fin within a micro channel
Deep reinforcement learning and mesh deformation integration for shape optimization of a single pin fin within a micro channel Open
View article: Optimising shapes of multiple pin fins in a microchannel using deep reinforcement learning and mesh deformation techniques
Optimising shapes of multiple pin fins in a microchannel using deep reinforcement learning and mesh deformation techniques Open
The utilisation of advanced pin fin designs in microchannels is useful for enhancing cooling efficiency. Advancements in machine learning and processing power have sparked interest in shape optimisation techniques. This research employs a …
View article: A new LED-based extinction tomography method for measurement of aerosol surface area
A new LED-based extinction tomography method for measurement of aerosol surface area Open
A light-emitting-diode (LED) based optical technique is developed to measure the surface area per unit volume of particles in aerosols and liquid sprays. The technique uses path-integrated measurements of transmittance, T, from two angles …
View article: Phase-sensitive optical coherence tomography reveals droplet penetration into a powder bed
Phase-sensitive optical coherence tomography reveals droplet penetration into a powder bed Open
View article: Effects of the deformation and size of the upper airway on the deposition of aerosols
Effects of the deformation and size of the upper airway on the deposition of aerosols Open
Aerosol drug delivery in the human airway is significantly affected by the morphology and size of the airway. This work developed a CFD-DEM model to simulate and analyze air flow and powder dynamics in combined inhaler-airway systems with …
View article: Chronoamperometric interrogation of an electrochemical aptamer-based sensor with tetrahedral DNA nanostructure pendulums for continuous biomarker measurements
Chronoamperometric interrogation of an electrochemical aptamer-based sensor with tetrahedral DNA nanostructure pendulums for continuous biomarker measurements Open
Tetrahedral DNA nanostructure (TDN) is highly promising in developing electrochemical aptamer-based (E-AB) sensors for biomolecular detection, owing to its inherit programmability, spatial orientation and structural robustness. However, cu…
View article: Numerical and experimental evaluation of nasopharyngeal aerosol administration methods in children with adenoid hypertrophy
Numerical and experimental evaluation of nasopharyngeal aerosol administration methods in children with adenoid hypertrophy Open
View article: Comparative Study of Inhaled Corticosteroid Deposition in Pediatric Mouth-Throat Airway with Tonsil Hypertrophy
Comparative Study of Inhaled Corticosteroid Deposition in Pediatric Mouth-Throat Airway with Tonsil Hypertrophy Open
View article: An experimental study of the effect of individual upper airway anatomical features on the deposition of dry powder inhaler formulations
An experimental study of the effect of individual upper airway anatomical features on the deposition of dry powder inhaler formulations Open
This study aims to investigate the effects of different pharynx anatomical features on the delivery of inhaled aerosols. Six in-vitro upper airway models reconstructed using anatomical images acquired by Magnetic Resonance Imaging (MRI) we…
View article: Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study
Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study Open
View article: Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler
Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler Open
An optically accessible research dry powder inhaler (DPI) was used to investigate the impact of initial acceleration during inhalation on the powder evacuation and drug dispersion processes. The inhaler featured a swirling chamber connecte…
View article: Critical review on thermohydraulic performance enhancement in channel flows: A comparative study of pin fins
Critical review on thermohydraulic performance enhancement in channel flows: A comparative study of pin fins Open
Effective thermal management is critical for optimising device performance, extending product longevity, saving energy, protecting the environment, and avoiding thermal failures. The above highlights the importance of studying heat transfe…
View article: A Comparative Study of R134a and Propane (R290) as Refrigerants in Heat Pump Water Heaters
A Comparative Study of R134a and Propane (R290) as Refrigerants in Heat Pump Water Heaters Open
In the context of decarbonization efforts, heat pump water heaters (HPWHs) offer an attractive solution over conventional electric resistance type hot water systems due to their 2-3 times higher efficiency. However, the high manufacturing …
View article: Numerical analysis of airflow and particle deposition in multi-fidelity designs of nasal replicas following nasal administration
Numerical analysis of airflow and particle deposition in multi-fidelity designs of nasal replicas following nasal administration Open
A physical replica manufactured without sections of the middle meatus could still be adequate in producing useful data on the deposition efficiencies associated with an intranasal drug formulation and its delivery device.
View article: A pendulum-type electrochemical aptamer-based sensor for continuous, real-time and stable detection of proteins
A pendulum-type electrochemical aptamer-based sensor for continuous, real-time and stable detection of proteins Open
Continuous detection of proteins is crucial for health management and biomedical research. Electrochemical aptamer-based (E-AB) sensor that relies on binding affinity between a recognition oligonucleotide and its specific target is a versa…
View article: Challenges in the Development and Application of Organ-on-Chips for Intranasal Drug Delivery Studies
Challenges in the Development and Application of Organ-on-Chips for Intranasal Drug Delivery Studies Open
With the growing demand for the development of intranasal (IN) products, such as nasal vaccines, which has been especially highlighted during the COVID-19 pandemic, the lack of novel technologies to accurately test the safety and effective…
View article: Biotechnology and Bioengineering: Volume 120, Number 3, March 2023
Biotechnology and Bioengineering: Volume 120, Number 3, March 2023 Open
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View article: Microfluidics assembly of inhalable liposomal ciprofloxacin characterised by an innovative in vitro pulmonary model
Microfluidics assembly of inhalable liposomal ciprofloxacin characterised by an innovative in vitro pulmonary model Open
Respiratory tract infections (RTIs) are reported to be the leading cause of death worldwide. Delivery of liposomal antibiotic nano-systems via the inhalation route has drawn significant interest in RTIs treatment as it can directly target …
View article: A Combined Experimental and Numerical Platform for Characterizing Particle Deposition in Physiologically Realistic Airway Models
A Combined Experimental and Numerical Platform for Characterizing Particle Deposition in Physiologically Realistic Airway Models Open
View article: Real‐time in‐situ electrochemical monitoring of <i>Pseudomonas aeruginosa</i> biofilms grown on air–liquid interface and its antibiotic susceptibility using a novel dual‐chamber microfluidic device
Real‐time in‐situ electrochemical monitoring of <i>Pseudomonas aeruginosa</i> biofilms grown on air–liquid interface and its antibiotic susceptibility using a novel dual‐chamber microfluidic device Open
Biofilms are communities of bacterial cells encased in a self‐produced polymeric matrix that exhibit high tolerance toward environmental stress. Despite the plethora of research on biofilms, most P. aeruginosa biofilm models are cultured o…
View article: Biotechnology and Bioengineering: Volume 119, Number 6, June 2022
Biotechnology and Bioengineering: Volume 119, Number 6, June 2022 Open
Dynamic modelling of N 2 O emissions from a