Explanipedia

Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application Open

Ling Yin, Chengchao Ding, Hongliang Zhang, Yuhua Shang, Chaoyang Fu , et al. · 2025

Adeno‐associated virus (AAV) is a non‐enveloped DNA virus infecting a wide variety of species, tissues, and cell types, which is recognized as a safe and effective method for delivering therapeutic transgenes. AAV vector is the most popula…

Evidence of an emerging triple-reassortant H3N3 avian influenza virus in China Open

Lei He, Yuhao Zhang, Kaixin Si, Chuan Yu, Ke Shang , et al. · 2024

The H3 subtype of avian influenza virus (AIV) stands out as one of the most prevalent subtypes, posing a significant threat to public health. In this study, a novel triple-reassortant H3N3 AIV designated A/chicken/China/16/2023 (H3N3), was…

Are the original SARS‐CoV‐2 novel mutants from in vitro culture able to escape the immune response? Open

Jun He, Qingmin Mei, Yousong Peng, Jiajia Xie, Weiwei Li , et al. · 2023

Monitoring variations in the virus genome to understand the SARS‐CoV‐2 evolution and spread of the virus is extremely important. Seven early SARS‐CoV‐2 isolates in China were cultured in vitro and were analyzed for their viral infectivity …

Evaluation of humoral immune responses induced by different SARS‐CoV‐2 spike trimers from wild‐type and emerging variants with individual, sequential, and combinational delivered strategies Open

Chengchao Ding, Shuangshuang Ni, Xiangyu Zhang, Jiajia Xie, Yong Sun , et al. · 2022

The spike trimer of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an effective target for inducing neutralizing antibodies by coronavirus disease 2019 (COVID‐19) vaccines. However, the diversity of spike protein from emer…

Corrigendum to “Biochemical characterization of SARS-CoV-2 nucleocapsid protein” Open

Weihong Zeng, Guangfeng Liu, Huan Ma, Dan Zhao, Yunru Yang , et al. · 2022

Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2 Open

Jiajia Xie, Chengchao Ding, Jun He, Yuqing Zhang, Shuangshuang Ni , et al. · 2021

The mutants resulted from the ongoing SARS-CoV-2 epidemic have showed resistance to antibody neutralization and vaccine-induced immune response. The present study isolated and identified two novel SARS-CoV-2 neutralizing antibodies (nAbs) …

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies Open

Chengchao Ding, Jun He, Xiangyu Zhang, Chengcheng Jiang, Yong Sun , et al. · 2021

Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To i…

Employing Broadly Neutralizing Antibodies as a Human Immunodeficiency Virus Prophylactic & Therapeutic Application Open

Chengchao Ding, Darshit Patel, Yunjing Ma, Jamie F. S. Mann, Jian Wu , et al. · 2021

Despite the discovery that the human immunodeficiency virus 1 (HIV-1) is the pathogen of acquired immunodeficiency syndrome (AIDS) in 1983, there is still no effective anti-HIV-1 vaccine. The major obstacle to the development of HIV-1 vacc…

Digital PCR assay for the effective detection of COVID-19 patients with SARS-CoV-2 low viral load Open

Yong Sun, Chengchao Ding, Qingqing Chen, Jiajia Xie, Junling Yu , et al. · 2021

Characterization of SARS-CoV-2-specific antibodies in COVID-19 patients reveals highly potent neutralizing IgA Open

Weihong Zeng, Huan Ma, Chengchao Ding, Yunru Yang, Yong Sun , et al. · 2021

Mutation and Virulence of SARS-CoV-2 Strains Circulating in Anhui Province, China Open

Jun He, Jiajia Xie, Yousong Peng, Chengchao Ding, Weiwei Li , et al. · 2021

Influence of Freezing Treatment on the Thermal Runaway Characteristics of Lithium-Ion Batteries Open

Jingwen Weng, Dongxu Ouyang, Mei‐Yu Chen, Chengchao Ding, Jian Wang · 2020

Owing to increasing applications of lithium-ion batteries (LIBs), it is worth investigating the thermal runaway (TR) behaviors of LIBs under extreme conditions such as flash freezing, which has been proposed as a feasible way for LIB trans…

Biochemical characterization of SARS-CoV-2 nucleocapsid protein Open

Weihong Zeng, Guangfeng Liu, Huan Ma, Dan Zhao, Yunru Yang , et al. · 2020

Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test Open

Jiajia Xie, Chengchao Ding, Jing Li, Yulan Wang, Hui Guo , et al. · 2020

Coronavirus disease (COVID‐19), caused by a novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has rapidly developed into a pandemic since it was first reported in December 2019. Nucleic acid testing is th…

COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by chemiluminescence immunoanalysis Open

Huan Ma, Weihong Zeng, Hongliang He, Dan Zhao, Yunru Yang , et al. · 2020

Background The pandemic of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing great loss. Detecting viral RNAs is standard approach for SARS-CoV-2 diagnosis with variable success. Currently, studies describing the …

Advances in Developing CAR T-Cell Therapy for HIV Cure Open

Jinxin Qi, Chengchao Ding, Xian Jiang, Yong Gao · 2020

Acquired immune deficiency syndrome (AIDS), which is caused by HIV infection, is an epidemic disease that has killed millions of people in the last several decades. Although combination antiretroviral therapy (cART) has enabled tremendous …

Clinical and Laboratory Profiles of 75 Hospitalized Patients with Novel Coronavirus Disease 2019 in Hefei, China Open

Zonghao Zhao, Jiajia Xie, Ming Yin, Yun Yang, Hongliang He , et al. · 2020

The outbreak of the novel coronavirus disease 2019 (COVID-19) infection began in December 2019 in Wuhan, and rapidly spread to many provinces in China. The number of cases has increased markedly in Anhui, but information on the clinical ch…

Attenuated Listeria monocytogenes as a Vaccine Vector for the Delivery of OMPW, the Outer Membrane Protein of Aeromonas hydrophila Open

Haijuan Zeng, Manman Xie, Chengchao Ding, Junfei Ma, Dongpo Xu , et al. · 2020

Listeria monocytogenes (LM) is a gram-positive facultative intracellular pathogen that could stimulate host to produce inflammatory response, cell-mediated immunity, and humoral immunity. In this study, an attenuated live vector vac…

Modulated production of endogenous anti-HIV broadly neutralising antibodies Open

Yong Gao, Darshit Patel, Chengchao Ding, Yilei Ma, W. Li , et al. · 2019

Development of a Bacterial Macroarray for the Rapid Screening of Targeted Antibody-Secreted Hybridomas Open

Jie Li, Xuzhao Zhai, Chengchao Ding, Yali Liu, Qingli Dong , et al. · 2018

Hybridoma screening is a key step for the successful generation of high-affinity analyte-specific monoclonal antibodies (MAbs). This work presents an innovative screening method, known as a bacterial macroarray, generated by contact printi…

Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice Open

Guanhao Wang, Qing Liu, Liang Guo, Haijuan Zeng, Chengchao Ding , et al. · 2018

Alcohol abuse is a major public health crisis. Relative evidences supported that the gut microbiota (GM) played an important role in central nervous system (CNS) function, and the composition of them had changed after alcohol drinking. We …

Comparison between gold nanoparticles and FITC as the labelling in lateral flow immunoassays for rapid detection of <i>Ralstonia solanacearum</i> Open

Lan Ma, Shujuan Wang, Dongpo Xu, Manman Xie, Chengchao Ding , et al. · 2018

Early prevention and monitoring of Ralstonia solanacearum (Rs) on nightshade is extremely critical for potent prevention and treatment of bacterial wilt disease. We developed two kinds of lateral flow immunochromatographic strip (LFICS) us…

Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection Open

Xin Xin QIU, Qiang Fu, Meng Cui, S S Yu, Y M Zhan , et al. · 2016

Newcastle disease virus; phosphoprotein; RNA editing; G insertion.

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