Chengchen Wu
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View article: Bioaccumulation and toxicity of hexafluoropropylene oxide homologs in Manila clams (Ruditapes philippinarum) compared with PFOA: correlates with molecular backbone length
Bioaccumulation and toxicity of hexafluoropropylene oxide homologs in Manila clams (Ruditapes philippinarum) compared with PFOA: correlates with molecular backbone length Open
View article: Research on the Construction of Mobile Terminal Assisted Language Learning Model Based on Artificial Intelligence Technology
Research on the Construction of Mobile Terminal Assisted Language Learning Model Based on Artificial Intelligence Technology Open
This paper aims to construct a mobile terminal-assisted language learning model based on artificial intelligence technology. It provides an overview of the development of language learning research and introduces the evolution from compute…
View article: Supplementary Table S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying all the reagents used in this study with information regarding the supplier, catalog number and RRID (antibodies).
View article: Supplementary Table S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying the information regarding the data collection and refinement statistics for the crystal structures of MBP-B2 and MBP-B2 C213A-A216V
View article: Supplementary Figure S5 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S5 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S5 displays how B2 trimer is essential for PML-RARA microspeckle formation in progenitors and PML NB disruption as well as PML/RARA degradation ex vivo, as well as for PML NB formation and sumoylation in vivo
View article: Supplementary Movie S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Movie S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Supplementary movie 2 shows Incomplete PML NBs fusion upon ATO treatment (1µM, 1h) in MEFs
View article: Supplementary Table S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying all the reagents used in this study with information regarding the supplier, catalog number and RRID (antibodies).
View article: Supplementary Figure S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S4 illustrates how trivalent arsenic binding to C213 in the B2 trimer leads to PML NB aggregation, and defective sumoylation and degradation of the trimer mutants, as well as the role of C213 mutants on PML partner localization and …
View article: Supplementary Movie S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Movie S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Supplementary movie 1 shows PML NBs fusion in MEFs, where two PML NBs undergo complete fusion and relaxation into one body
View article: Supplementary Table S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying the cell lines used in this study with their origin/RRID
View article: Supplementary Figure S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S2 shows Crystal structure of MBP-B2 fusion protein, and the similarity between the 3D structure of PML B2 and other TRIM proteins, yet its formation relies on specific amino acids
View article: Supplementary Figure S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S4 illustrates how trivalent arsenic binding to C213 in the B2 trimer leads to PML NB aggregation, and defective sumoylation and degradation of the trimer mutants, as well as the role of C213 mutants on PML partner localization and …
View article: Supplementary Figure S5 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S5 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S5 displays how B2 trimer is essential for PML-RARA microspeckle formation in progenitors and PML NB disruption as well as PML/RARA degradation ex vivo, as well as for PML NB formation and sumoylation in vivo
View article: Data from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Data from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
PML nuclear bodies (NB) are disrupted in PML-RARA–driven acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) cures 70% of patients with APL, driving PML-RARA degradation and NB reformation. In non-APL cells, arsenic binding onto PML…
View article: Supplementary Table S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying the cell lines used in this study with their origin/RRID
View article: Supplementary Table S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S4 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying the information regarding the data collection and refinement statistics for the crystal structures of MBP-B2 and MBP-B2 C213A-A216V
View article: Supplementary Movie S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Movie S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Supplementary movie 2 shows Incomplete PML NBs fusion upon ATO treatment (1µM, 1h) in MEFs
View article: Supplementary Figure S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S1 illustrates LLPS hallmarks of PML nuclear bodies and highlights that their assembly does not rely on intermolecular disulfide bonds
View article: Supplementary Table S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying the primers used for site-directed mutagenesis.
View article: Supplementary Movie S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Movie S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Supplementary movie 1 shows PML NBs fusion in MEFs, where two PML NBs undergo complete fusion and relaxation into one body
View article: Supplementary Figure S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S1 illustrates LLPS hallmarks of PML nuclear bodies and highlights that their assembly does not rely on intermolecular disulfide bonds
View article: Supplementary Figure S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S3 shows that PML B2 trimer controls NB distribution and dynamics ranging from a liquid-like bodies to filaments
View article: Supplementary Figure S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S2 shows Crystal structure of MBP-B2 fusion protein, and the similarity between the 3D structure of PML B2 and other TRIM proteins, yet its formation relies on specific amino acids
View article: Supplementary Table S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Table S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Table displaying the primers used for site-directed mutagenesis.
View article: Supplementary Figure S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Supplementary Figure S3 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
Figure S3 shows that PML B2 trimer controls NB distribution and dynamics ranging from a liquid-like bodies to filaments
View article: Data from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Data from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
PML nuclear bodies (NB) are disrupted in PML-RARA–driven acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) cures 70% of patients with APL, driving PML-RARA degradation and NB reformation. In non-APL cells, arsenic binding onto PML…
View article: Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function Open
PML nuclear bodies (NB) are disrupted in PML-RARA–driven acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) cures 70% of patients with APL, driving PML-RARA degradation and NB reformation. In non-APL cells, arsenic binding onto PML…
View article: Data from Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy
Data from Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy Open
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and overall association with favorable therapeutic responses remain incompletely understood.…
View article: Key Resources Table from Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy
Key Resources Table from Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy Open
Key resource table with RRID
View article: Supplementary Figures and Methods from Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy
Supplementary Figures and Methods from Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy Open
Supplementary figures and methods