Explanipedia

SIMAIS: A swarm intelligence inspired biosensor for rapid protein detection Open

Jiahao Zheng, Bayinqiaoge Bayinqiaoge, H. Schiff, Xin Wang, Tingquan Wu , et al. · 2025

Swarm intelligence, the collective behaviour of animals such as birds, fish, and ants, arises from simple local interactions and enables survival, efficient foraging, and decision-making without central control. Inspired by this principle,…

Discovery of insect Blaps rhynchopetera Fairmaire extracts with anti-tyrosinase activity and anti-melanin deposition Open

Haoyang Zhang, Kaixun Cao, Xi Yang, Shengwen Zhou, James Mwangi , et al. · 2025

Background Blaps rhynchopetera Fairmaire is a medicinal insect that has been used for a long time by minority ethnic groups in Yunnan, China, due to its immunomodulatory function. However, its potential applications in cosmetics have not b…

Stimuli-responsive smart materials enabled high-performance biosensors for liquid biopsies Open

Xiaoqi Gao, Bayinqiaoge Bayinqiaoge, Ming Li, Rona Chandrawati, Xiangpeng Li , et al. · 2025

Rational design of site-specific artificial metallonucleases for therapeutic applications Open

Xixi Lu, Chengchen Zhang · 2025

Artificial metallonucleases (ArMNs) are synthetic nucleases that utilise metals as the catalytic centre for cleaving nucleic acids, with the metal component present in the form of ions, complexes or nanoparticles. ArMNs have been developed…

Hairpin-locker mediated CRISPR/Cas tandem system for ultrasensitive detection of DNA without pre-amplification Open

Fei Deng, Rui Sang, Yi Li, Biyao Yang, Xiwen Zhai , et al. · 2025

Achieving ultra-sensitive detection of DNA is of paramount importance in the field of molecular analytics. Conventional amplification technologies such as polymerase chain reaction (PCR) currently play a leading role in ultrasensitive DNA …

Circular DNA enhanced amplification-free CRISPR/Cas12a assays for end-user friendly ultra-sensitive Porphyromonas gingivalis diagnosis Open

Xuan Wu, Ningning Pi, Fei Deng, Shi‐Yang Tang, Chengchen Zhang , et al. · 2024

Periodontitis not only leads to tooth loss but is also associated with various systemic symptoms. Porphyromonas gingivalis (Pg) is the microorganism most closely linked to periodontitis. A rapid and accurate Pg detection method holds signi…

Composites from Self‐Assembled Protein Nanofibrils and Liquid Metal Gallium Open

Li Liu, Md. Arifur Rahim, Tianchen Li, Mohamed Kilani, Yilin He , et al. · 2024

Gallium (Ga), a low‐melting‐point liquid metal with soft, metallic, and biocompatible properties, offers many possibilities. However, the potential of composites that integrate Ga with biomacromolecules, combining their biocompatibility, e…

Key molecular DNA damage responses of human cells to radiation Open

Chengchen Zhang, Jibin Liu, Jun Wu, Kamakshi Ranjan, Xiaopeng Cui , et al. · 2024

Our understanding of the DNA damage responses of human cells to radiation has increased remarkably over the recent years although some notable signaling events remain to be discovered. Here we provide a brief account of the key molecular e…

Navigating the Aerosolized Frontier: A Comprehensive Review of Bioaerosol Research Post-COVID-19 Open

Chengchen Zhang, Xiaorong Dai, Tedros Gebrezgiabhier, Yuan Wang, Mengrong Yang , et al. · 2024

In the wake of the COVID-19 pandemic, the scientific community has been galvanized to unravel the enigmatic role of bioaerosols in the transmission of infectious agents. This literature review, anchored in the extensive Web of Science Core…

Hairpin-locker mediated CRISPR/Cas tandem system for ultrasensitive detection of DNA without pre-amplification Open

Fei Deng, Rui Sang, Yi Li, Biyao Yang, Xiwen Zhai , et al. · 2024

Achieving ultra-sensitive detection of DNA is of paramount importance in the field of molecular analytics. Conventional amplification technologies such as polymerase chain reaction (PCR) currently play a leading role in ultrasensitive DNA …

Integrated RPA-CRISPR/Cas12a system towards Point-of-Care H. pylori detection Open

Yi Li, Fei Deng, Chengchen Zhang, Xiaofen Lin, Ewa M. Goldys · 2023

The rapidly advanced CRISPR/Cas biosensing technology provides unprecedent potential for the development of novel biosensing systems. It provides a new approach for realizing rapid, sensitivity and highly specific pathogen nucleic acid det…

RNA reporter based CRISPR/Cas12a biosensing platform for sensitive detection of circulating tumor DNA Open

Fei Deng, Yi Li, Rui Sang, Chengchen Zhang, Tim Hall , et al. · 2023

CRISPR/Cas biotechnology provides an exceptional platform for biosensor development. To date, the reported CRISPR/Cas biosensing systems have shown extraordinary performance for nucleic acids, small molecules, small proteins and microorgan…

Paper-based lateral flow assay for the point-of-care detection of neurofilament light chain Open

Chengchen Zhang, Fei Deng, Yi Li, Tim Hall, Ewa M. Goldys · 2023

Neurofilament light chain (NF-L) is a protein found in neurons of the nervous system and is widely used as a biomarker for neurological disorders. However, the current methods for detecting NF-L levels are complicated, expensive, and requi…

A Non-Newtonian liquid metal enabled enhanced electrography Open

Veronika Timosina, Tim Cole, Hongda Lu, Jian Shu, Xiangbo Zhou , et al. · 2023

Biopotential signals, like electrocardiography (ECG), electromyography (EMG), and electroencephalography (EEG), can help diagnose cardiological, musculoskeletal and neurological disorders. Dry silver/silver chloride (Ag/AgCl) electrodes ar…

Impact of Undertreatment of Depression on Suicide Risk Among Children and Adolescents With Major Depressive Disorder: A Microsimulation Study Open

Chengchen Zhang, Zafar Zafarí, Julia F. Slejko, Wendy Camelo Castillo, Gloria Reeves , et al. · 2023

Undertreatment of depression is common among children and adolescents, but evidence of the impact of undertreatment of depression on risk of suicide is limited due to the low base rate of suicide in the population and lack of sufficient da…

Influence of Healthy Brand and Diagnosticity of Brand Name on Subjective Ratings of High- and Low-Calorie Food Open

Chengchen Zhang, Jiayi Han, Xiyu Guo, Jianping Huang · 2023

Brand names on food packaging and the diagnosticity of brand names have notable effects on consumer preferences. However, their effects on healthy food consumption are not clear. The objective of this study was to investigate the effect of…

Encrusting Mof Nanoparticles Onto Nanofibers Via Spray-Initiated Synthesis to Boost the Filtration Performances of Nanofiber Membranes Open

Ye Bian, Zhuolun Niu, Yue Pan, Chengchen Zhang, Chun Chen , et al. · 2023

Mechanistic Observation of Interactions between Macrophages and Inorganic Particles with Different Densities Open

Chengchen Zhang, Jianbo Tang, Wanjie Xie, Francois‐Marie Allioux, Zhenbang Cao , et al. · 2022

Many different types of inorganic materials are processed into nano/microparticles for medical utilization. The impact of selected key characteristics of these particles, including size, shape, and surface chemistries, on biological system…

Cell‐Mediated Biointerfacial Phenolic Assembly for Probiotic Nano Encapsulation Open

Franco Centurion, Salma Merhebi, Mahroo Baharfar, Roozbeh Abbasi, Chengchen Zhang , et al. · 2022

The use of cell‐mediated chemistry is an emerging strategy that exploits the metabolic processes of living cells to develop biomimetic materials with advanced functionalities and enhanced biocompatibility. Here, a concept of a cell‐mediate…

TNet: Transmission Network Inference Using Within-Host Strain Diversity and its Application to Geographical Tracking of COVID-19 Spread Open

Saurav Dhar, Chengchen Zhang, Ion Măndoiu, Mukul S. Bansal · 2021

The inference of disease transmission networks is an important problem in epidemiology. One popular approach for building transmission networks is to reconstruct a phylogenetic tree using sequences from disease strains sampled from infecte…

Post-transition metal/polymer composites for the separation and sensing of alkali metal ions Open

Salma Merhebi, Munirah Mohammad, Mohannad Mayyas, Roozbeh Abbasi, Chengchen Zhang , et al. · 2021

Post-transition metal composites were fabricated and used for the sensing of alkali metal ions towards the recovery of Li + from mixed salt aqueous solutions.

TreeFix-TP: Phylogenetic Error-Correction for Infectious Disease Transmission Network Inference Open

Samuel Sledzieski, Chengchen Zhang, Ion Măndoiu, Mukul S. Bansal · 2020

Carbonization of low thermal stability polymers at the interface of liquid metals Open

Francois‐Marie Allioux, Salma Merhebi, Jianbo Tang, Chengchen Zhang, Andrea Merenda , et al. · 2020

TreeFix-TP: Phylogenetic error-correction for infectious disease transmission network inference Open

Samuel Sledzieski, Mukul S. Bansal, Ion Măndoiu · 2020

Many existing methods for estimation of infectious disease transmission networks use a phylogeny of the infecting strains as the basis for transmission network inference, and accurate network inference relies on accuracy of this underlying…

TreeFix-TP: Phylogenetic Error-Correction for Infectious Disease Transmission Network Inference Open

Samuel Sledzieski, Chengchen Zhang, Ion Măndoiu, Mukul S. Bansal · 2019

Background Many existing methods for estimation of infectious disease transmission networks use a phylogeny of the infecting strains as the basis for transmission network inference, and accurate network inference relies on accuracy of this…

Discovery of Inhibitors of Aurora/PLK Targets as Anticancer Agents Open

Baowen Qi, Ling Zhong, Jun He, Hongjia Zhang, Fengqiong Li , et al. · 2019

Aurora and polo-like kinases control the G2/M phase in cell mitosis, which are both considered as crucial targets for cancer cell proliferations. Here, naphthalene-based Aurora/PLK coinhibitors as leading compounds were designed through in…

Magnetic Resonance Image-Based Modeling for Neurosurgical Interventions Open

Yongqiang Li, Changxin Lai, Chengchen Zhang, Alexa J. Singer, Suhao Qiu , et al. · 2019

Surgeries such as implantation of deep brain stimulation devices require accurate placement of devices within the brain. Because placement affects performance, image guidance and robotic assistance techniques have been widely... | Find, re…

Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging Open

Yiyao Liu, Ting‐Ting Li, Xue Shen, Yin Chen, Chengchen Zhang , et al. · 2015

Engineering a safe and high-efficiency delivery system for efficient RNA interference is critical for successful gene therapy. In this study, we designed a novel nanocarrier system of polyethyleneimine (PEI)-modified Fe3O4@SiO2, which allo…

Network analysis suggests a potentially ‘evil’ alliance of opportunistic pathogens inhibited by a cooperative network in human milk bacterial communities Open

Zhanshan Ma, Qiong Guan, Chengxi Ye, Chengchen Zhang, James A. Foster , et al. · 2015

The critical importance of human milk to infants and even human civilization has been well established. Yet our understanding of the milk microbiome has been limited to cataloguing OTUs and computation of community diversity. To the best o…

Acknowledgement to the Reviewers Open

Silvano Bertelloni, Giampiero I. Baroncelli, Francesco Massart, Silvia Einaudi, Małgorzata Waśniewska , et al. · 2015

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