Chengde Wang
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View article: Simulation research on the characteristics of fire smoke spread and personnel evacuation in the railway passenger station
Simulation research on the characteristics of fire smoke spread and personnel evacuation in the railway passenger station Open
As crucial nodes in railway transportation networks, railway passenger stations can suffer significant casualties and adverse societal impacts during fire accidents. A numerical simulation test was conducted on fire smoke spread and person…
View article: Stem cell therapy offers new hope for the treatment of Alzheimer’s disease
Stem cell therapy offers new hope for the treatment of Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily characterized by memory impairment and cognitive decline, for which no curative treatment is currently available. Existing therapeutic strategies, such as choli…
View article: ROS-Responsive Cinnamaldehyde Polymer Nanoparticles Loaded with Puerarin for the Treatment of Atherosclerosis
ROS-Responsive Cinnamaldehyde Polymer Nanoparticles Loaded with Puerarin for the Treatment of Atherosclerosis Open
Puerarin (PU) helps slow down and control the harmful progression of atherosclerosis (AS) by reducing inflammation, inhibiting foam cell formation, and exhibiting anticoagulant effects. However, its clinical application is limited due to i…
View article: Kartagener Syndrome Complicated by Middle and Lower Lobar Mucinous Adenocarcinoma in the Left Lung
Kartagener Syndrome Complicated by Middle and Lower Lobar Mucinous Adenocarcinoma in the Left Lung Open
This represents the first documented case of KS coexisting with pulmonary invasive mucinous adenocarcinoma, to some extent expanding the clinical spectrum of ciliopathy-associated lung malignancies. It suggests that clinicians and radiolog…
View article: Dynamic stratified porosity computation from canopy interaction simulation between airflow and leaves
Dynamic stratified porosity computation from canopy interaction simulation between airflow and leaves Open
The main goal of wind-driven spraying is to use assisted airflow to disrupt the structure of branches and leaves and broaden the air delivery channel, so as to achieve uniform droplet deposition in the middle and lower parts of the canopy.…
View article: Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology
Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology Open
Paclitaxel is an herbal active ingredient used in clinical practice that shows anti-tumor effects. However, its biological activity, mechanism, and cancer cell-killing effects remain unknown. Information on the chemical gene interactions o…
View article: Construction and validation of a glioblastoma prognostic model based on immune-related genes
Construction and validation of a glioblastoma prognostic model based on immune-related genes Open
Background Glioblastoma multiforme (GBM) is a common malignant brain tumor with high mortality. It is urgently necessary to develop a new treatment because traditional approaches have plateaued. Purpose Here, we identified an immune-relate…
View article: A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma
A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma Open
Background Glioblastoma (GBM) is one of the most malignant types of tumors in the central nervous system, and the 5-year survival remains low. Several studies have shown that preoperative peripheral blood tests and preoperative conventiona…
View article: Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1
Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1 Open
Brusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is known regarding its role and underlying mechanism in glioblastoma cells. Here, we found that Bru could inhibit the proliferation of glioblast…
View article: A Six-Immune-Related Genes Prognostic Signature for Glioblastoma
A Six-Immune-Related Genes Prognostic Signature for Glioblastoma Open
Background: Glioblastoma (GBM) multiforme is a common malignant brain tumor with high mortality. It is urgently necessary to develop a new treatment because traditional approaches have reached a bottleneck. Purpose : Here we created an imm…
View article: Surgery and Medical Treatment in Microprolactinoma: A Systematic Review and Meta-Analysis
Surgery and Medical Treatment in Microprolactinoma: A Systematic Review and Meta-Analysis Open
Objective. Dopamine agonists (DAs) are recommended as the first-line treatment for prolactinomas; however, tumour recurrence after drug withdrawal remains a clinical problem. Recent studies have reported high remission rates via surgery in…
View article: Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling
Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling Open
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown. Bortezomib (BTZ)…
View article: Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas
Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas Open
Cabergoline (CAB) is the first choice for treatment of prolactinoma and the most common subtype of pituitary adenoma. However, drug resistance and lack of effectiveness in other pituitary tumor types remain clinical challenges to this trea…
View article: A Quantified Risk-Scoring System for the Recurrence of Meningiomas: Results From a Retrospective Study of 392 Patients
A Quantified Risk-Scoring System for the Recurrence of Meningiomas: Results From a Retrospective Study of 392 Patients Open
Aim: This study aimed to identify the independent risk factors of recurrence in patients undergoing primary resection of meningioma and construct a scoring system for the prediction of the risk of postoperative recurrence. Materials and Me…
View article: Application effect of two modalities for placing lumbar drain catheters in patients with postcraniotomy aseptic meningitis
Application effect of two modalities for placing lumbar drain catheters in patients with postcraniotomy aseptic meningitis Open
Aim: Aseptic meningitis is an unfortunate complication after craniotomy. Continuous lumbar drainage is a safe and effective method for treating postcraniotomy aseptic meningitis. This study compared the incidence of cerebrospinal fluid (CS…
View article: β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion Open
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to the CD274 gene promoter region to induce PD-L1 expression, …
View article: Regenerative Potential of Menstrual Blood-Derived Stem Cells and Platelet-Derived Growth Factor in Endometrial Injury
Regenerative Potential of Menstrual Blood-Derived Stem Cells and Platelet-Derived Growth Factor in Endometrial Injury Open
BACKGROUND Endometrial regeneration is essential for normal endometrial function; however, it is unclear whether and how menstrual blood-derived stem cells (MenSCs) and platelet-derived growth factor (PGDF) are associated with this phenome…
View article: General mechanism of JQ1 in inhibiting various types of cancer
General mechanism of JQ1 in inhibiting various types of cancer Open
Bromodomain‑containing 4 (BRD4) is a histone modification reader and transcriptional regulator that has been reported to interact with acetylated lysine histone motifs transcription factors (TFs), transcription co‑activators and RNA polyme…
View article: Temozolomide promotes immune escape of GBM cells via upregulating PD-L1.
Temozolomide promotes immune escape of GBM cells via upregulating PD-L1. Open
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor with poor prognosis, and currently effective therapeutic strategies are still limited. Although temozolomide (TMZ) is commonly used for GBM therapy and its mech…
View article: miR‑34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage
miR‑34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage Open
Insights into the roles of microRNAs (miRNAs/miRs) in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches in the treatment of glioma. miR‑34a, as a well‑known tumo…
View article: Effects of endometrial stem cell transplantation combined with estrogen in the repair of endometrial injury
Effects of endometrial stem cell transplantation combined with estrogen in the repair of endometrial injury Open
The present study investigated the effects of endometrial stem cell (EnSCs) transplantation combined with estrogen in the repair of endometrial injury. A total of 30 patients with intrauterine adhesions (IUA) and 30 healthy individuals wer…
View article: CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells
CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells Open
Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC tr…
View article: Src Promotes Metastasis of Human Non-Small Cell Lung Cancer Cells through Fn14-Mediated NF-κB Signaling
Src Promotes Metastasis of Human Non-Small Cell Lung Cancer Cells through Fn14-Mediated NF-κB Signaling Open
BACKGROUND Src and Fn14 are implicated in the aggressiveness of non-small cell lung cancer (NSCLC) cells, yet the molecular mechanism is not fully understood. MATERIAL AND METHODS The proliferation, migration, and invasion of HCC827 cells …
View article: Enhanced recovery after surgery (ERAS) programs for esophagectomy protocol for a systematic review and meta-analysis
Enhanced recovery after surgery (ERAS) programs for esophagectomy protocol for a systematic review and meta-analysis Open
Our study will draw an objective conclusion of the comparisons between ERAS and conventional care in aspects of perioperative outcomes and provide level I evidences for clinical decision makings.
View article: RETRACTED: DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy
RETRACTED: DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy Open
Insulin-like growth factor I (IGF-I) has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE) was shown to be induced by elevated intracranial dopamine (DA). The beneficial effect of …
View article: Glutathione S-transferase A1 mediates nicotine-induced lung cancer cell metastasis by promoting epithelial-mesenchymal transition
Glutathione S-transferase A1 mediates nicotine-induced lung cancer cell metastasis by promoting epithelial-mesenchymal transition Open
The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro. Furthermore, the effect of GSTA1 on the epithelial-mesench…