Changyi Ji
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View article: Gut microbiota and metabolomics in metabolic dysfunction-associated fatty liver disease: interaction, mechanism, and therapeutic value
Gut microbiota and metabolomics in metabolic dysfunction-associated fatty liver disease: interaction, mechanism, and therapeutic value Open
The global epidemic of Metabolic dysfunction-associated fatty liver disease (MAFLD) urgently demands breakthroughs in precision medicine strategies. Its pathogenesis centers on the cascade dysregulation of the gut microbiota-metabolite-liv…
View article: When HEV Infection Meets Organ Transplantation
When HEV Infection Meets Organ Transplantation Open
Hepatitis E virus (HEV), a single-stranded RNA virus, is a leading cause of acute viral hepatitis globally. In recent years, the incidence of hepatitis E has increased significantly, making it a major public health concern globally. Solid …
View article: Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies
Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies Open
Tauopathies are neurodegenerative diseases characterized by pathological tau accumulation, leading to motor and neuropsychiatric symptoms. Effective tau-targeting therapies remain a major challenge. Here, we present 1D9-LIRΔTP53INP2, a sin…
View article: The Gut Microbiota in Elderly Patients with Acute Hepatitis E Infection
The Gut Microbiota in Elderly Patients with Acute Hepatitis E Infection Open
The relative abundance of Bacteroidetes significantly distinguished AHE-elderly patients from healthy controls and could more accurately predict recovery outcomes in elderly AHE patients. These findings suggest new strategies for pr…
View article: Neuronal hypofunction and network dysfunction in a mouse model at early stage of tauopathy
Neuronal hypofunction and network dysfunction in a mouse model at early stage of tauopathy Open
Background Abnormal neuronal activity was observed in awake and behaving tauopathy mice using two‐photon calcium imaging. Our previous study has revealed the relationship between tau pathology and altered neuronal calcium dynamics within t…
View article: Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy
Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy Open
INTRODUCTION It is unclear how early neuronal deficits occur in tauopathies, if these are associated with changes in neuronal network activity, and if they can be alleviated with therapies. METHODS To address this, we performed in vivo two…
View article: Single-domain antibody-based protein degrader for synucleinopathies
Single-domain antibody-based protein degrader for synucleinopathies Open
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, a…
View article: Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy
Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy Open
We previously reported altered neuronal Ca 2+ dynamics in the motor cortex of 12-month-old JNPL3 tauopathy mice during quiet wakefulness or forced running, with a tau antibody treatment significantly restoring the neuronal Ca 2+ activity p…
View article: Single-Domain Antibody-Based Protein Degrader for Synucleinopathies
Single-Domain Antibody-Based Protein Degrader for Synucleinopathies Open
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, a…
View article: BAG3 regulates RAB35 mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome pathway and Tau clearance
BAG3 regulates RAB35 mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome pathway and Tau clearance Open
Background Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer’s disease (AD). Emerging studies implicate impairment of the endosome‐lysosome pathway as a significant…
View article: Importance of functional outcome measures when evaluating the efficacy of tau immunotherapies
Importance of functional outcome measures when evaluating the efficacy of tau immunotherapies Open
Background Tau immunotherapies are promising approaches to treat Alzheimer’s disease and other tauopathies. Using in vivo two‐photon calcium imaging, we have observed altered neuronal calcium activity in behaving JNPL3 tauopathy mice at bo…
View article: Tau-targeting therapies for Alzheimer disease: current status and future directions
Tau-targeting therapies for Alzheimer disease: current status and future directions Open
View article: BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance
BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance Open
View article: Current Status of Clinical Trials on Tau Immunotherapies
Current Status of Clinical Trials on Tau Immunotherapies Open
View article: BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance
BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance Open
Background Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer’s disease (AD). Emerging studies implicate impairment of the endosome-lysosome pathway as a significant…
View article: Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice
Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice Open
View article: Structural and functional characterization of the bestrophin-2 anion channel
Structural and functional characterization of the bestrophin-2 anion channel Open
View article: Dual Ca2+-Dependent Gates in Human Bestrophin1 Underlie Disease-Causing Mechanisms of Gain-Of-Function Mutations
Dual Ca2+-Dependent Gates in Human Bestrophin1 Underlie Disease-Causing Mechanisms of Gain-Of-Function Mutations Open
View article: Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations
Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations Open
View article: Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations
Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations Open
View article: BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes Open
A major cellular catabolic pathway in neurons is macroautophagy/autophagy, through which misfolded or aggregation-prone proteins are sequestered into autophagosomes that fuse with lysosomes, and are degraded. MAPT (microtubule-associated p…
View article: Dissecting the Structure and Function of Bestrophin Channels
Dissecting the Structure and Function of Bestrophin Channels Open
View article: BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes Open
A major cellular catabolic pathway in neurons is macroautophagy/autophagy, through which misfolded or aggregation-prone proteins are sequestered into autophagosomes that fuse with lysosomes, and are subsequently degraded. MAPT (microtubule…
View article: ATP activates bestrophin ion channels through direct interaction
ATP activates bestrophin ion channels through direct interaction Open
View article: Depletion of astrocytic transglutaminase 2 improves injury outcomes
Depletion of astrocytic transglutaminase 2 improves injury outcomes Open
View article: Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner Open
View article: Inhibition or ablation of transglutaminase 2 impairs astrocyte migration
Inhibition or ablation of transglutaminase 2 impairs astrocyte migration Open
View article: Molecular mechanisms of non‐transferrin‐bound and transferring‐bound iron uptake in primary hippocampal neurons
Molecular mechanisms of non‐transferrin‐bound and transferring‐bound iron uptake in primary hippocampal neurons Open
The molecular mechanisms of iron trafficking in neurons have not been elucidated. In this study, we characterized the expression and localization of ferrous iron transporters Zip8, Zip14 and divalent metal transporter 1 ( DMT 1), and ferri…