Changfeng Zhu
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View article: AND Logic Gate-Based Dual-Specificity DNA Circuit for Isothermal HBV rcDNA Detection
AND Logic Gate-Based Dual-Specificity DNA Circuit for Isothermal HBV rcDNA Detection Open
The quantitative analysis of blood HBV DNA is essential for controlling the spread of HBV and improving the prognosis of individuals infected with the virus. Yet the HBV genome exhibits complex variation, such as multiple-site mutations fo…
View article: Spatial heterogeneity and seasonal succession of phytoplankton community in the Cosmonaut Sea, East Antarctica: driving forces and implications
Spatial heterogeneity and seasonal succession of phytoplankton community in the Cosmonaut Sea, East Antarctica: driving forces and implications Open
Understanding the dynamics of the phytoplankton community in the marginal seas of the Southern Ocean is crucial for delineating its role in global carbon cycling. This study investigated spatiotemporal variations in phytoplankton community…
View article: Contributions of Transparent Exopolymer Particles by Specific Phytoplankton Groups in the Cosmonaut Sea, East Antarctic
Contributions of Transparent Exopolymer Particles by Specific Phytoplankton Groups in the Cosmonaut Sea, East Antarctic Open
Transparent exopolymer particles (TEP) play a crucial role in marine carbon cycling. While phytoplankton are known to be the primary contributors to TEP, the impact of changes in phytoplankton community structure on TEP production in natur…
View article: Clinical observation and immune effect of high-intensity focused ultrasound (HIFU) treatment on patients with colorectal cancer liver metastasis
Clinical observation and immune effect of high-intensity focused ultrasound (HIFU) treatment on patients with colorectal cancer liver metastasis Open
HIFU significantly improves OS in CRC liver metastasis patients and reduces serum IL-6 levels, suggesting enhanced immune responses.
View article: Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant <i>Staphylococcus aureus</i>
Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant <i>Staphylococcus aureus</i> Open
The increasing prevalence of methicillin‐resistant Staphylococcus aureus (MRSA) due to antibiotic misuse necessitates novel therapeutic strategies to counter multidrug‐resistant infections. Here, we introduce a self‐assembling, aggregation…
View article: Highly sensitive electrochemical immunosensor based on methylene blue-reduced graphene oxide nanocomposites as signal probes for IL-6 detection in gingival crevicular fluid samples
Highly sensitive electrochemical immunosensor based on methylene blue-reduced graphene oxide nanocomposites as signal probes for IL-6 detection in gingival crevicular fluid samples Open
As an important inflammatory cytokine, interleukin-6 (IL-6) can mediate the entire pathological process of periodontitis and is closely associated with the degree of inflammation. Therefore, it is critical to develop convenient quantitativ…
View article: A Unique Two‐Step Process Combining Acid and Alkaline Etching for Recovering High‐Purity Silicon from Waste Crystalline Silicon Solar Panels
A Unique Two‐Step Process Combining Acid and Alkaline Etching for Recovering High‐Purity Silicon from Waste Crystalline Silicon Solar Panels Open
Effective resource recovery and reuse are important to overcome the enormous challenges associated with waste photovoltaic (PV) module management and limited raw material supply, but these processes are severely hampered by the inefficient…
View article: <scp>tRF</scp>‐3a‐Pro: A Transfer <scp>RNA</scp>‐Derived Small <scp>RNA</scp> as a Novel Biomarker for Diagnosis of Hepatitis B Virus‐Related Hepatocellular Carcinoma
<span>tRF</span>‐3a‐Pro: A Transfer <span>RNA</span>‐Derived Small <span>RNA</span> as a Novel Biomarker for Diagnosis of Hepatitis B Virus‐Related Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most challenging malignancies of the digestive system. Screening for novel biomarkers and therapeutic targets is a promising strategy to enhance HCC prognosis. Recently, liquid biopsy with circu…
View article: Sensitive Detection of Biomarker in Gingival Crevicular Fluid Based on Enhanced Electrochemiluminescence by Nanochannel-Confined Co3O4 Nanocatalyst
Sensitive Detection of Biomarker in Gingival Crevicular Fluid Based on Enhanced Electrochemiluminescence by Nanochannel-Confined Co3O4 Nanocatalyst Open
The sensitive detection of inflammatory biomarkers in gingival crevicular fluid (GCF) is highly desirable for the evaluation of periodontal disease. Luminol-based electrochemiluminescence (ECL) immunosensors offer a promising approach for …
View article: Recycling Co and Li from Spent Lithium-Ion Batteries with the Silicon of Retired Photovoltaics Panels
Recycling Co and Li from Spent Lithium-Ion Batteries with the Silicon of Retired Photovoltaics Panels Open
View article: Human 3d Liver Spheroidssupport Productive Infection of a Novel Tick-Borne Phenuivirus
Human 3d Liver Spheroidssupport Productive Infection of a Novel Tick-Borne Phenuivirus Open
View article: Crystal structure of 2-chloro-4-fluorobenzyl 2-acetoxybenzoate, C<sub>16</sub>H<sub>12</sub>ClFO<sub>4</sub>
Crystal structure of 2-chloro-4-fluorobenzyl 2-acetoxybenzoate, C<sub>16</sub>H<sub>12</sub>ClFO<sub>4</sub> Open
C 16 H 12 ClFO 4 , monoclinic, C 2/ c (no. 15), a = 25.653(8) Å, b = 8.368(3) Å, c = 13.809(6) Å, β = 104.342(15)°, V = 2871.9(9) Å 3 , Z = 8, R gt ( F ) = 0.0287, wR ref ( F 2 ) = 0.0713, T = 218(2) K.
View article: Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horseradish peroxidase
Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horseradish peroxidase Open
Early diagnosis and treatment of gastric cancer (GC) play a vital role in improving efficacy, reducing mortality and prolonging patients' lives. Given the importance of early detection of gastric cancer, an electrochemical biosensor was de…
View article: Emotional Perceptions of Thermal Comfort for People Exposed to Green Spaces Characterized Using Streetscapes in Urban Parks
Emotional Perceptions of Thermal Comfort for People Exposed to Green Spaces Characterized Using Streetscapes in Urban Parks Open
Thermal comfort is a key determinant ruling the quality of urban park visits that is mainly evaluated by equivalent meteorological factors and lacks evidence about its relationship with emotional perception. Exposure to green space was bel…
View article: Designer cellular spheroids with DNA origami for drug screening
Designer cellular spheroids with DNA origami for drug screening Open
Current in vitro models struggle to balance the complexity of human diseases with suitability for large-scale drug tests. While 3D cultures simulate human tissues, they lack cellular intricacy, and integrating these models with high-throug…
View article: Spin texture and tunneling magnetoresistance in atomically thin CrSBr
Spin texture and tunneling magnetoresistance in atomically thin CrSBr Open
The exploration of spin configurations and magnetoresistance in van der Waals magnetic semiconductors, particularly in the realm of thin-layer structures, is of paramount significance for the development of two-dimensional spintronic nanod…
View article: Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid
Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid Open
View article: Leveraging Concentration Imbalance-Driven DNA Circuit as an Operational Amplifier to Enhance the Sensitivity of Hepatitis B Virus DNA Detection with Hybridization-Responsive DNA-Templated Silver Nanoclusters
Leveraging Concentration Imbalance-Driven DNA Circuit as an Operational Amplifier to Enhance the Sensitivity of Hepatitis B Virus DNA Detection with Hybridization-Responsive DNA-Templated Silver Nanoclusters Open
Hepatitis B virus (HBV) infection remains a major global health concern, necessitating the development of sensitive and reliable diagnostic methods. In this study, we propose a novel approach to enhance the sensitivity of HBV DNA detection…
View article: Iodine Status of Infants and Toddlers under 2 Years of Age and Its Association with Feeding Behaviors and Maternal Iodine Status in Shanghai: A Quantile Regression Analysis
Iodine Status of Infants and Toddlers under 2 Years of Age and Its Association with Feeding Behaviors and Maternal Iodine Status in Shanghai: A Quantile Regression Analysis Open
It is crucial to provide adequate iodine nutrition to infants and toddlers for proper thyroid function and subsequent brain development. Infants are particularly vulnerable to iodine deficiency during the transition from a milk-based diet …
View article: Evaluating the impact of delayed centrifugation on protein profiles analyzed by LC/MS in serum and plasma samples
Evaluating the impact of delayed centrifugation on protein profiles analyzed by LC/MS in serum and plasma samples Open
The pre-analytical steps in blood-based liquid biopsy, involving sample collection techniques and storage conditions, play a critical role in ensuring the integrity and reliability of collected samples. These steps have a directly impact o…
View article: A bioenergetically‐active ploy (glycerol sebacate)‐based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism
A bioenergetically‐active ploy (glycerol sebacate)‐based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism Open
Diabetic wounds impose significant burdens on patients' quality of life and healthcare resources due to impaired healing potential. Factors like hyperglycemia, oxidative stress, impaired angiogenesis and excessive inflammation contribute t…
View article: Recycling Co and Li from Spent Lithium-Ion Batteries with the Silicon of Retired Photovoltaics Panels
Recycling Co and Li from Spent Lithium-Ion Batteries with the Silicon of Retired Photovoltaics Panels Open
View article: Designer Cellular Spheroids with DNA Origami for Drug Screening
Designer Cellular Spheroids with DNA Origami for Drug Screening Open
In vitro models are crucial for drug screening, yet they often fail to accurately reflect human physiological responses. While 3D cell cultures aim to simulate human tissues, many lack the detailed complexity and interaction of various cel…
View article: Metallic W/WO2 solid-acid catalyst boosts hydrogen evolution reaction in alkaline electrolyte
Metallic W/WO2 solid-acid catalyst boosts hydrogen evolution reaction in alkaline electrolyte Open
The lack of available protons severely lowers the activity of alkaline hydrogen evolution reaction process than that in acids, which can be efficiently accelerated by tuning the coverage and chemical environment of protons on catalyst surf…
View article: Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species Open
Adverse skin reactions caused by ionizing radiation are collectively called radiation dermatitis (RD), and the use of nanomedicine is an attractive approach to this condition. Therefore, we designed and large-scale synthesized fullerenols …
View article: Label-Free Detection of T4 Polynucleotide Kinase Activity and Inhibition via Malachite Green Aptamer Generated from Ligation-Triggered Transcription
Label-Free Detection of T4 Polynucleotide Kinase Activity and Inhibition via Malachite Green Aptamer Generated from Ligation-Triggered Transcription Open
Polynucleotide kinase (PNK) is a key enzyme that is necessary for ligation-based DNA repair. The activity assay and inhibitor screening for PNK may contribute to the prediction and improvement of tumor treatment sensitivity, respectively. …
View article: Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling
Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling Open
Background and Aims: Liver fibrosis is a leading indicator for increased mortality and long-term comorbidity in NASH. Activation of HSCs and excessive extracellular matrix production are the hallmarks of liver fibrogenesis. Tyrosine kinase…
View article: Exploring the Key Factors for the Formation of DNA Hydrogels Via Dual Rolling Circle Amplification
Exploring the Key Factors for the Formation of DNA Hydrogels Via Dual Rolling Circle Amplification Open
View article: Retaining Gestalt integration in working memory requires domain-specific attention
Retaining Gestalt integration in working memory requires domain-specific attention Open
Human beings always need to deal with discrete information in a flow. Working memory (WM) plays an essential role in integrating fragments into meaningful units. Recent studies have found that WM can realize the Gestalt cues within the sto…
View article: A Turn-Off Fluorescent Strategy for Calprotectin Detection Based on the Inhibitory Effect of Calprotectin upon the Activity of Zn(Ⅱ)-Dependent DNAzyme
A Turn-Off Fluorescent Strategy for Calprotectin Detection Based on the Inhibitory Effect of Calprotectin upon the Activity of Zn(Ⅱ)-Dependent DNAzyme Open
Calprotectin (CP) is an established biomarker that allows the noninvasive evaluation of inflammation levels in the gastrointestinal tract of patients with inflammatory bowel disease and is helpful for the diagnosis and management of the di…