Chenglan Jiang
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View article: CircSP3 modulates apoptosis and participates in inorganic arsenic carcinogenesis through phosphorylation and ubiquitination of p65
CircSP3 modulates apoptosis and participates in inorganic arsenic carcinogenesis through phosphorylation and ubiquitination of p65 Open
Inorganic arsenic (iAs) is a well-established carcinogen known to dysregulate gene expression, but its impact on circular RNAs (circRNAs) remains poorly characterized. Here, we demonstrated that NaAsO₂ (20, 40, 60 μmol/L) upregulated circS…
View article: Computational strategies in tumor phylogenetics: evaluating multimodal integration and methodological trade-offs across study designs
Computational strategies in tumor phylogenetics: evaluating multimodal integration and methodological trade-offs across study designs Open
Motivation Tumor clonal evolution represents a dynamic ecosystem underpinned by genetic alterations and Darwinian selection, posing major challenges due to intratumoral heterogeneity and therapy resistance. Although computational methods h…
View article: The transcript NR 134251.1 of lncRNA APTR with an opposite function to all transcripts inhibits proliferation and induces apoptosis by regulating proliferation and apoptosis-related genes
The transcript NR 134251.1 of lncRNA APTR with an opposite function to all transcripts inhibits proliferation and induces apoptosis by regulating proliferation and apoptosis-related genes Open
Arsenic (As) exposure has been a global public health concern for hundreds of millions worldwide. LncRNA APTR (Alu-mediated p21 transcriptional regulator) plays an essential role in tumor growth and development. However, its function in ar…
View article: Polymorphism of FEN1 Gene is Associated with DNA Damage of Cytb Gene in Arsenic-Exposed Workers
Polymorphism of FEN1 Gene is Associated with DNA Damage of Cytb Gene in Arsenic-Exposed Workers Open
Objective: To explore the relationship between Polymorphism of FEN1 Gene and DNA Damage of Cytb Gene in Arsenic-Exposed Workers. Methods: The content of arsenide in urine of 79 arsenic-exposed workers and 24 agricultural workers was detect…
View article: Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study
Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study Open
The lung cancer incidence in the Xuanwei and neighboring region, Yunnan, China, is among the highest in China and is attributed to severe air pollution with high benzo(a)pyrene levels. We systematically and comparatively analyzed DNA methy…