Chenghua Liu
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View article: <i>Staphylococcus aureus</i> β-hemolysin impairs oxygen transport without causing hemolysis
<i>Staphylococcus aureus</i> β-hemolysin impairs oxygen transport without causing hemolysis Open
Staphylococcus aureus (S. aureus) infection can lead to the occurrence of hypoxia, however, the underlying mechanisms have not been fully elucidated. β-hemolysin (Hlb) induced hemolysis of red blood cells (RBCs) requires a te…
View article: A novel single-domain antibody obtained from immune Bactrian camels against botulinum toxin type A using SPR-based screening method
A novel single-domain antibody obtained from immune Bactrian camels against botulinum toxin type A using SPR-based screening method Open
View article: Performance Benchmarking of Open-Source Antibody Design Tools: A Holistic Evaluation from Structure Prediction to Epitope Analysis
Performance Benchmarking of Open-Source Antibody Design Tools: A Holistic Evaluation from Structure Prediction to Epitope Analysis Open
View article: Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis
Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis Open
View article: Development and characterization of an antibody that recognizes influenza virus N1 neuraminidases
Development and characterization of an antibody that recognizes influenza virus N1 neuraminidases Open
Influenza A viruses (IAVs) continue to pose a huge threat to public health, and their prevention and treatment remain major international issues. Neuraminidase (NA) is the second most abundant surface glycoprotein on influenza viruses, and…
View article: Study on the Preparation and Aging Performance of Temperature-Indicating Patch Used for Thermal Defect Detection of Transformer Bushing Cylinder Head
Study on the Preparation and Aging Performance of Temperature-Indicating Patch Used for Thermal Defect Detection of Transformer Bushing Cylinder Head Open
Elevated temperatures at the transformer bushing cylinder head can precipitate failures, leading to significant power outages. In response, this study introduces a reversible temperature-indicating patch for the nuanced detection of therma…
View article: Study on Carbon Footprint of Cold Chain Logistics of Agricultural Products in Sichuan Province Based on LCA Method
Study on Carbon Footprint of Cold Chain Logistics of Agricultural Products in Sichuan Province Based on LCA Method Open
Under the “dual carbon” goal, the contradiction between the growth of agricultural product cold chain logistics demand and the low-carbon economy goal is becoming increasingly prominent. As a key link connecting production and consumption,…
View article: <i>Staphylococcus aureus</i> β-hemolysin causes skin inflammation by acting as an agonist of epidermal growth factor receptor
<i>Staphylococcus aureus</i> β-hemolysin causes skin inflammation by acting as an agonist of epidermal growth factor receptor Open
Staphylococcus aureus is a common cause of inflammatory skin diseases, with one of its virulence factors, β-hemolysin (Hlb), known to promote skin colonization. However, its direct involvement in skin inflammation is unclear. In this study…
View article: Functional epitopes and neutralizing antibodies of vaccinia virus
Functional epitopes and neutralizing antibodies of vaccinia virus Open
Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health. Smallpox was declared eradicated in 1980, and Many…
View article: Analysis of Grain Production Efficiency Differences in China Based on DEA-Malmquist Index
Analysis of Grain Production Efficiency Differences in China Based on DEA-Malmquist Index Open
This paper presents a cross-sectional analysis of the data related to the input and output of grain production efficiency in 31 provinces of China in 2020 through the DEA-BCC model.It is concluded that the overall pure technical efficiency…
View article: Framework for Quality Evaluation of Smart Roadside Infrastructure Sensors for Automated Driving Applications
Framework for Quality Evaluation of Smart Roadside Infrastructure Sensors for Automated Driving Applications Open
The use of smart roadside infrastructure sensors is highly relevant for future applications of connected and automated vehicles. External sensor technology in the form of intelligent transportation system stations (ITS-Ss) can provide safe…
View article: Build A Multi-Dimensional Collaborative Logistics Talent Training Model -Taking Chengdu University of Information Technology as an example
Build A Multi-Dimensional Collaborative Logistics Talent Training Model -Taking Chengdu University of Information Technology as an example Open
The “Opinions of the Ministry of Education on Accelerating the Construction of High-level Undergraduate Education to Comprehensively Improve the Ability of Talent Training (Jiao Gao [2018] No. 2)” clearly requires that the formation of a h…
View article: Research on the Evaluation of Logistics Efficiency and Influencing Factors in Sichuan Province
Research on the Evaluation of Logistics Efficiency and Influencing Factors in Sichuan Province Open
In order to investigate the development of regional logistics efficiency, a logistics efficiency evaluation index system was constructed from three dimensions: logistics efficiency input, logistics efficiency output and influencing factors…
View article: Analysis on the Influencing Factors of Cold Chain Logistics Development of Fresh Agricultural Products in Sichuan Province
Analysis on the Influencing Factors of Cold Chain Logistics Development of Fresh Agricultural Products in Sichuan Province Open
In recent years, with the development of social economy, cold chain logistics has developed rapidly in China. Fresh agricultural products are one of the main objects of cold chain logistics. Cold chain logistics is closely related to the p…
View article: Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells
Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells Open
CRISPR/Cas9 mediated precise gene editing requires homology-directed repair (HDR), which occurs less frequently than non-homologous end-joining (NHEJ) including the canonical NHEJ and alternative NHEJ (Alt-EJ) in mammalian cells, especiall…
View article: Research on the Factors Affecting the Quality of Fresh E-Commerce Logistics Services
Research on the Factors Affecting the Quality of Fresh E-Commerce Logistics Services Open
Based on the 4M1E management rule, the factors influencing the service quality of fresh produce e-commerce logistics are constructed from five dimensions: human, machine, material, law and environment, and the empirical analysis is conduct…
View article: Effect of long noncoding RNA NONHSAT070806 on the apoptosis, proliferation, migration, invasion and tumorigenesis of bladder cancer
Effect of long noncoding RNA NONHSAT070806 on the apoptosis, proliferation, migration, invasion and tumorigenesis of bladder cancer Open
NONHSAT070806 may act as a suppressor of BC and is a potential indicator of the invasiveness of BC.
View article: Stationary Diffusion State Neural Estimation for Multiview Clustering
Stationary Diffusion State Neural Estimation for Multiview Clustering Open
Although many graph-based clustering methods attempt to model the stationary diffusion state in their objectives, their performance limits to using a predefined graph. We argue that the estimation of the stationary diffusion state can be a…
View article: Corrigendum: A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis
Corrigendum: A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis Open
[This corrects the article DOI: 10.3389/fimmu.2021.656090.].
View article: Stationary Diffusion State Neural Estimation for Multiview Clustering
Stationary Diffusion State Neural Estimation for Multiview Clustering Open
Although many graph-based clustering methods attempt to model the stationary diffusion state in their objectives, their performance limits to using a predefined graph. We argue that the estimation of the stationary diffusion state can be a…
View article: Identification of a Human Anti-Alpha-Toxin Monoclonal Antibody Against Staphylococcus aureus Infection
Identification of a Human Anti-Alpha-Toxin Monoclonal Antibody Against Staphylococcus aureus Infection Open
Staphylococcus aureus is a major pathogenic bacterium that causes a variety of clinical infections. The emergence of multi-drug resistant mechanisms requires novel strategies to mitigate S. aureus infection. Alpha-hemolysin (Hla) is a key …
View article: Antibodies Against Pseudomonas aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme
Antibodies Against Pseudomonas aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme Open
Extracellular traps released by neutrophils (NETs) are essential for the clearance of Pseudomonas aeruginosa . Alkaline protease (AprA) secreted by P. aeruginosa negatively correlates with clinical improvement. Moreover, anti-AprA in patie…
View article: Staphylococcus aureus β-Hemolysin Up-Regulates the Expression of IFN-γ by Human CD56bright NK Cells
Staphylococcus aureus β-Hemolysin Up-Regulates the Expression of IFN-γ by Human CD56bright NK Cells Open
IFN-γ is produced upon stimulation with S. aureus and may play a detrimental role during infection. However, whether hemolysins play a role in the mechanism of IFN-γ production has not been fully characterized. In this study, we demonstrat…
View article: A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis
A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis Open
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple autoantibody production and often affects the kidneys, known as lupus nephritis. However, the mechanism underlying lupus nephritis development is unclear. Bi…
View article: Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway Open
BACKGROUND Wogonin (5,7-dihydroxy-8-methoxyflavone), one of flavonoids isolated from the Scutellaria baicalensis, has been regarded as an anticancer candidate because of its maximal efficacy in cancer cells. This study aimed to explore the…
View article: Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus
Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus Open
Our findings revealed that neutralizing bicomponent leukocidins may be a promising strategy to combat infections caused by S. aureus.
View article: Twenty-seven-nucleotide repeat insertion in the<i>rplV</i>gene confers specific resistance to macrolide antibiotics in<i>Staphylococcus aureus</i>
Twenty-seven-nucleotide repeat insertion in the<i>rplV</i>gene confers specific resistance to macrolide antibiotics in<i>Staphylococcus aureus</i> Open
Macrolide antibiotics are used for treatment of soft-tissue infection caused by Staphylococcus aureus in humans. However, infections with S. aureus are increasingly difficult to treat owing to the emergence and rapid spread o…
View article: Effectiveness and safety of combinational therapy compared with intensified statin monotherapy in patients with coronary heart disease
Effectiveness and safety of combinational therapy compared with intensified statin monotherapy in patients with coronary heart disease Open
Reducing the plasma levels of low-density lipoprotein-cholesterol (LDL-C) is critical for patients with coronary heart disease (CHD). Conventional treatment with statins alone may not achieve the goal of lowering LDL-C due to drug intolera…
View article: Frequency Clustering Analysis for Resting State Functional Magnetic Resonance Imaging Based on Hilbert-Huang Transform
Frequency Clustering Analysis for Resting State Functional Magnetic Resonance Imaging Based on Hilbert-Huang Transform Open
Objective: Exploring resting-state functional networks using functional magnetic resonance imaging (fMRI) is a hot topic in the field of brain functions. Previous studies suggested that the frequency dependence between blood oxygen …