Chengjun Ma
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View article: Paeonol eradicates biofilm in porcine-source Escherichia coli by targeting the quorum sensing system
Paeonol eradicates biofilm in porcine-source Escherichia coli by targeting the quorum sensing system Open
Background Natural active compounds hold significant potential to overcome biofilm-mediated resistance, offering a promising therapeutic strategy for combating bacterial biofilms resistance. The present study was designed to investigate th…
View article: Effect of anti-biofilm peptide CRAMP-34 on the biofilms of Acinetobacter lwoffii derived from dairy cows
Effect of anti-biofilm peptide CRAMP-34 on the biofilms of Acinetobacter lwoffii derived from dairy cows Open
Dairy mastitis is one of the most common diseases in dairy farming, and the formation of pathogenic bacteria biofilms may be an important reason why traditional antibiotic therapy fails to resolve some cases of dairy mastitis. We isolated …
View article: Functionalized xanthohumol nanoemulsion: fabrication, characterization and bioavailability enhancement of bioactive compounds
Functionalized xanthohumol nanoemulsion: fabrication, characterization and bioavailability enhancement of bioactive compounds Open
BACKGROUND Xanthohumol is an isopentadienyl flavonoid in hops, which have several pharmacological effects. However, due to the poor bioavailability of xanthohumol, it cannot be widely used. RESULT In this study, solvent extraction combined…
View article: Tannic acid inhibits Escherichia coli biofilm formation and underlying molecular mechanisms: Biofilm regulator CsgD
Tannic acid inhibits Escherichia coli biofilm formation and underlying molecular mechanisms: Biofilm regulator CsgD Open
Biofilms often engender persistent infections, heightened antibiotic resistance, and the recurrence of infections. Therefor, infections related to bacterial biofilms are often chronic and pose challenges in terms of treatment. The main tra…
View article: Impact of CRAMP-34 on Pseudomonas aeruginosa biofilms and extracellular metabolites
Impact of CRAMP-34 on Pseudomonas aeruginosa biofilms and extracellular metabolites Open
Biofilm is a structured community of bacteria encased within a self-produced extracellular matrix. When bacteria form biofilms, they undergo a phenotypic shift that enhances their resistance to antimicrobial agents. Consequently, inducing …
View article: Case report: A case of new mutation in SERPINC1 leading to thrombotic microangiopathy
Case report: A case of new mutation in SERPINC1 leading to thrombotic microangiopathy Open
Introduction: Hereditary antithrombin-III deficiency can significantly increase the risk for thrombosis, which is common in limb deep vein and pulmonary cases. However, thrombotic microangiopathy (TMA) caused by hereditary antithrombin def…
View article: Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity
Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity Open
Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective developme…
View article: Research on "Non-Key Disciplines" Students' Institutional Support in Double-First Class Universities in Beijing
Research on "Non-Key Disciplines" Students' Institutional Support in Double-First Class Universities in Beijing Open
Currently "double first-class" construction focuses on high-level advantage disciplines. However, practical operation ignores many "non-key disciplines" and their students' development. The research took Beijing as an example, adopted a mi…
View article: Effects of perindopril on the swallowing reflex in a rat dysphagia model induced by ligation of bilateral common carotid arteries (BCAO)
Effects of perindopril on the swallowing reflex in a rat dysphagia model induced by ligation of bilateral common carotid arteries (BCAO) Open
Dysphagia, as one cause of aspiration pneumonia, is a major complication in the patients with cerebrovascular disease, Parkinson's disease, aging, and overdose of antipsychotic drugs. To evaluate the effects of the chemicals on dysphagia, …
View article: Protective Effects of Hippophae rhamnoides L. Phenylpropanoids on Doxorubicin-Induced Cardiotoxicity in Zebrafish
Protective Effects of Hippophae rhamnoides L. Phenylpropanoids on Doxorubicin-Induced Cardiotoxicity in Zebrafish Open
Hippophae rhamnoides L. is a deciduous shrub that contains many unique bioactive substances. This sea buckthorn possesses anticancer, antioxidant, anti-inflammatory, and cardiovascular protective properties. Herein, the effects of phenylpr…
View article: The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ25–35-Induced Neuroinflammation in PC-12 Cells
The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ25–35-Induced Neuroinflammation in PC-12 Cells Open
Dracocephalum heterophyllum (D. heterophyllum) is a traditional Chinese Tibetan medicine that has been used for the treatment of lymphitis, hepatitis, and bronchitis. However, only a few selected chemical components are currently obtained …
View article: Relationship Between Motivation and Learning Outcomes in E-learning among University Students in Malaysia
Relationship Between Motivation and Learning Outcomes in E-learning among University Students in Malaysia Open
COVID-19 pandemic has impacted the entire world, including Malaysia. Facing the increasing number of cases, educational institutions in Malaysia have forced to stop operations, and e- learning is mainly practiced among students of higher e…
View article: Cloning and Immunosuppressive Properties of an Acyl-Activating Enzyme from the Venom Apparatus of Tetrastichus brontispae (Hymenoptera: Eulophidae)
Cloning and Immunosuppressive Properties of an Acyl-Activating Enzyme from the Venom Apparatus of Tetrastichus brontispae (Hymenoptera: Eulophidae) Open
Venom injected into the host plays vital roles in facilitating successful parasitization and development for parasitoid wasps, especially those devoid of polydnavirus, and the abundant venom proteins appear to be most likely involved in pa…
View article: Emphysematous pyelonephritis and cystitis in a patient with uremia and anuria
Emphysematous pyelonephritis and cystitis in a patient with uremia and anuria Open
Introduction: Emphysematous pyelonephritis (EPN) or cystitis (EC) is a severe infection of the urinary tract with high mortality. EPN is uncommon among the patients of end stage of renal failure (ESRD) Case presentation: A 38-year-old male…
View article: Hydroxysafflor Yellow A Attenuates Lipopolysaccharide-Induced Neurotoxicity and Neuroinflammation in Primary Mesencephalic Cultures
Hydroxysafflor Yellow A Attenuates Lipopolysaccharide-Induced Neurotoxicity and Neuroinflammation in Primary Mesencephalic Cultures Open
Lipopolysaccharide (LPS)-induced neuroinflammation triggers and accelerates the pathogenesis of Parkinson’s disease (PD). Carthamus tinctorius L., a traditional Chinese medicine, has been widely used for the treatment of cerebrovascular di…
View article: Pantoprazole‑induced acute kidney injury: A case report
Pantoprazole‑induced acute kidney injury: A case report Open
The present study reports a case of pantoprazole-induced acute kidney disease. The patient was diagnosed with acute kidney injury with wide interstitial inflammation and eosinophil infiltration. Following 1 month of glucocorticoid therapy,…
View article: Predictive role of endothelin in left ventricular remodeling of chronic kidney disease
Predictive role of endothelin in left ventricular remodeling of chronic kidney disease Open
The results of the present study indicated that the level of serum ET-1 is closely related to the cardiac complications of CKD and is a useful predictor of cardiac complication.
View article: Nitrite-induced acute kidney injury with secondary hyperparathyroidism
Nitrite-induced acute kidney injury with secondary hyperparathyroidism Open
Nitrite-induced acute kidney injury with secondary hyperparathyroidism was relatively rare. After therapy, the function of the kidney and parathyroid returned to normal. This case suggests that detailed collection of medical history, physi…
View article: Polyphenol Stilbenes from Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3‐L1 Adipocytes
Polyphenol Stilbenes from Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3‐L1 Adipocytes Open
Fenugreek ( Trigonella foenum-graecum L.) is a well‐known annual plant that is widely distributed worldwide and has possessed obvious hypoglycemic and hypercholesterolemia characteristics. In our previous study, three polyphenol stilbenes …
View article: Rosmarinic Acid Alleviates the Endothelial Dysfunction Induced by Hydrogen Peroxide in Rat Aortic Rings via Activation of AMPK
Rosmarinic Acid Alleviates the Endothelial Dysfunction Induced by Hydrogen Peroxide in Rat Aortic Rings via Activation of AMPK Open
Endothelial dysfunction is the key player in the development and progression of vascular events. Oxidative stress is involved in endothelial injury. Rosmarinic acid (RA) is a natural polyphenol with antioxidative, antiapoptotic, and anti‐i…