Chengkang Zhang
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View article: From pollution to solution: How environmental protection tax shapes green technological innovation?
From pollution to solution: How environmental protection tax shapes green technological innovation? Open
This study examines the influence of environmental protection taxes on the advancement of green technological innovation within heavily polluted Chinese firms, a critical aspect in promoting sustainable development within heavily polluted …
View article: Molecular cloning and characterization of three carnitine palmitoyltransferase (cpt) isoforms from mud crab (Scylla paramamosain) and their roles in respond to fasting and ambient salinity stress
Molecular cloning and characterization of three carnitine palmitoyltransferase (cpt) isoforms from mud crab (Scylla paramamosain) and their roles in respond to fasting and ambient salinity stress Open
As rate-limiting enzymes of β-oxidation of fatty acids in mitochondria, the carnitine palmitoyltransferase (CPT) played an important role in regulating energy homeostasis of aquatic animals. However, there was very little research on β-oxi…
View article: CFHTF2 Is Needed for Vegetative Growth, Conidial Morphogenesis and the Osmotic Stress Response in the Tea Plant Anthracnose (Colletotrichum fructicola)
CFHTF2 Is Needed for Vegetative Growth, Conidial Morphogenesis and the Osmotic Stress Response in the Tea Plant Anthracnose (Colletotrichum fructicola) Open
Tea is an important cash crop worldwide, and its nutritional value has led to its high economic benefits. Tea anthracnose is a common disease of tea plants that seriously affects food safety and yield and has a far-reaching impact on the s…
View article: Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality
Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality Open
View article: Robust Expansion Of Human Blood-derived γδ T Cells Using A Chemically-defined Medium
Robust Expansion Of Human Blood-derived γδ T Cells Using A Chemically-defined Medium Open
Gamma delta (γδ) T cells have recently emerged as an attractive candidate for cancer immunotherapy treatments due to their inherent cytotoxicity against cancer cells. Moreover, γδ T cells provide a platform for allogeneic cell therapies as…
View article: How to improve mRNA-based CAR-T cell generation and functionality? A lab-scale comparison
How to improve mRNA-based CAR-T cell generation and functionality? A lab-scale comparison Open
Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical chimeric antigen receptor (CAR)-T cell therapies. Thereby, the key factor for cell viability, expansion, modification, and …
View article: Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models
Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models Open
Functional profiling of CFTR-directed therapeutics offers the potential to provide significant benefits to young people with cystic fibrosis (CF). However, the development of 2D airway epithelial cell models for individual response tests i…
View article: Using serum-free media to streamline and optimize CAR T-cell manufacturing workflows
Using serum-free media to streamline and optimize CAR T-cell manufacturing workflows Open
CAR T-cell therapies have led to breakthroughs in treating hematological malignancies, but the complexity and cost involved in their production limits their availability to patients. One challenge in CAR T-cell manufact…
View article: Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum
Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum Open
Multivesicular bodies (MVBs) are critical intermediates in the trafficking of ubiquitinated endocytosed surface proteins to the lysosome/vacuole for destruction. Recognizing and packaging ubiquitin modified cargoes to the MVB pathway requi…
View article: Distribution of Arsenic Resistance Genes in Prokaryotes
Distribution of Arsenic Resistance Genes in Prokaryotes Open
Arsenic is a metalloid that occurs naturally in aquatic and terrestrial environments. The high toxicity of arsenic derivatives converts this element in a serious problem of public health worldwide. There is a global arsenic geocycle in whi…
View article: Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling
Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling Open
View article: FgBud3, a Rho4-Interacting Guanine Nucleotide Exchange Factor, Is Involved in Polarity Growth, Cell Division and Pathogenicity of Fusarium graminearum
FgBud3, a Rho4-Interacting Guanine Nucleotide Exchange Factor, Is Involved in Polarity Growth, Cell Division and Pathogenicity of Fusarium graminearum Open
Rho GTPases are signaling macromolecules that are associated with developmental progression and pathogenesis of Fusarium graminearum. Generally, enzymatic activities of Rho GTPases are regulated by Rho GTPase guanine nucleotide exch…
View article: Overexpression of Prokineticin 2 in Transgenic Mice Leads to Reduced Circadian Behavioral Rhythmicity and Altered Molecular Rhythms in the Suprachiasmatic Clock
Overexpression of Prokineticin 2 in Transgenic Mice Leads to Reduced Circadian Behavioral Rhythmicity and Altered Molecular Rhythms in the Suprachiasmatic Clock Open
In mammals, the master pacemaker driving circadian rhythms is thought to reside in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. A clear view of molecular clock mechanisms within the SCN neurons has been elucidated. In con…
View article: <i>MoCDC14</i> is important for septation during conidiation and appressorium formation in <i>Magnaporthe oryzae</i>
<i>MoCDC14</i> is important for septation during conidiation and appressorium formation in <i>Magnaporthe oryzae</i> Open
Summary As a typical foliar pathogen, appressorium formation and penetration are critical steps in the infection cycle of Magnaporthe oryzae . Because appressorium formation and penetration are closely co‐regulated with the cell cycle, and…
View article: Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus
Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus Open
The retromer mediates protein trafficking through recycling cargo from endosomes to the trans-Golgi network in eukaryotes. However, the role of such trafficking events during pathogen-host interaction remains unclear. Here, we report that …
View article: FgNoxR, a regulatory subunit of NADPH oxidases, is required for female fertility and pathogenicity in<i>Fusarium graminearum</i>
FgNoxR, a regulatory subunit of NADPH oxidases, is required for female fertility and pathogenicity in<i>Fusarium graminearum</i> Open
Fusarium graminearum is a filamentous fungal pathogen that causes wheat Fusarium head blight. In this study, we identified FgNoxR, a regulatory subunit of NADPH oxidases (Nox) in F. graminearum, and found that it plays an important role in…
View article: FvBck1, a component of cell wall integrity MAP kinase pathway, is required for virulence and oxidative stress response in sugarcane Pokkah Boeng pathogen
FvBck1, a component of cell wall integrity MAP kinase pathway, is required for virulence and oxidative stress response in sugarcane Pokkah Boeng pathogen Open
Fusarium verticillioides (formerly F. moniliforme) is suggested as one of the causal agents of Pokkah Boeng, a serious disease of sugarcane worldwide. Currently, detailed molecular and physiological mechanism of pathogenesis is unknown. In…