Chenglu Yang
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View article: Research on the Development of China's New Energy Vehicle Industry in the New Economic Environment
Research on the Development of China's New Energy Vehicle Industry in the New Economic Environment Open
As China's new energy vehicle industry continues to grow, it is becoming more and more important to the country's economic development. After comprehensively considering the in-depth research results of many scholars on the relationship be…
View article: MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality
MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality Open
The MYC oncoprotein represents an intriguing target for cancer treatment, but its therapeutic potential has been hindered by the absence of specific pharmacological inhibitors. In this study, we demonstrate that the phenoxy quinoline compo…
View article: The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells
The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells Open
The mitotic regulator, Aurora kinase B (AURKB), is frequently overexpressed in malignancy and is a target for therapeutic intervention. The compound, LXY18, is a potent, orally available small molecule that inhibits the proper localization…
View article: Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound
Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound Open
Therapeutic targeting of MYC directly has proven difficult, but several means to target MYC indirectly using a synthetic lethal drug approach have been proposed. Synthetic lethal approaches for MYC have sought to take advantage of vulnerab…
View article: SARS-CoV-2 tetrameric RBD protein blocks viral infection and induces potent neutralizing antibody response
SARS-CoV-2 tetrameric RBD protein blocks viral infection and induces potent neutralizing antibody response Open
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed serious threats to global health and economy and calls for the development of safe treatments and effectiv…