Chengshuo Wang
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View article: An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trial
An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trial Open
View article: Comparative efficacy of deep transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation in improving lower extremity motor function in subacute stroke patients
Comparative efficacy of deep transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation in improving lower extremity motor function in subacute stroke patients Open
Background Deep transcranial magnetic stimulation (dTMS) is more beneficial in activating the leg muscle cortical representation. However, to date, no studies have evaluated the advantages of dTMS compared to repetitive transcranial magnet…
View article: TLR4+group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases
TLR4+group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases Open
View article: Effects of external diaphragm pacing combined with repetitive peripheral magnetic stimulation of the phrenic nerve on respiratory function in stroke patients
Effects of external diaphragm pacing combined with repetitive peripheral magnetic stimulation of the phrenic nerve on respiratory function in stroke patients Open
Objectives To investigate the effects of external diaphragmatic pacing (EDP) and repetitive peripheral magnetic stimulation (rPMS) of the phrenic nerve on respiratory function in stroke patients. Methods Fifty-four stroke patients were ran…
View article: Effects of long-term very high-altitude exposure on cardiopulmonary function of healthy adults in plain areas
Effects of long-term very high-altitude exposure on cardiopulmonary function of healthy adults in plain areas Open
Due to the unique plateau climate, such as low atmospheric pressure, hypoxia, cold, and dryness, people in plain areas will have a series of physiological and pathological changes after entering the plateau. This observational study was de…
View article: Clinical characteristics and biomarker screening for dry nose
Clinical characteristics and biomarker screening for dry nose Open
Background: Dry nose (DN) can be commonly observed in rhinitis, which can be objectively diagnosed; but it is usually ignored. Objective: The present work focused on analyzing clinical features, selecting biomarkers, and exploring the path…
View article: Epidemiology of common allergic diseases in China: Current position and implications
Epidemiology of common allergic diseases in China: Current position and implications Open
The prevalence of common allergic diseases, including allergic rhinitis, asthma, atopic dermatitis, and food allergy, has increased dramatically with rising industrialization in China, leading to a significant socio‐economic burden. These …
View article: Association between metabolic health indicators and cardiorespiratory fitness in urban young and middle-aged population: a retrospective cross-sectional study
Association between metabolic health indicators and cardiorespiratory fitness in urban young and middle-aged population: a retrospective cross-sectional study Open
Background Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular diseases (CVD). Compared with traditional clinical risk factors for CVD, CRF can better predict health status and possible adverse events. However,…
View article: Amphiregulin Mediates Epithelial Cell–Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps
Amphiregulin Mediates Epithelial Cell–Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps Open
Background Eosinophils easily accumulate in the intra‐epithelial layer and subepithelial regions in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). While several factors influence the migration of eosinophils from peripher…
View article: Stapokibart for moderate-to-severe seasonal allergic rhinitis: a randomized phase 3 trial
Stapokibart for moderate-to-severe seasonal allergic rhinitis: a randomized phase 3 trial Open
Seasonal allergic rhinitis (SAR) places a significant socioeconomic burden, particularly on individuals with poorly managed recurrent and severe symptoms despite standard-of-care treatment. Stapokibart, a humanized monoclonal antibody that…
View article: Efficacy and Safety of Combined Pharmacotherapies in Moderate‐to‐Severe Allergic Rhinitis: A Network Meta‐Analysis
Efficacy and Safety of Combined Pharmacotherapies in Moderate‐to‐Severe Allergic Rhinitis: A Network Meta‐Analysis Open
Background Combination pharmacotherapies are often selected for moderate‐to‐severe allergic rhinitis (AR), particularly when monotherapies do not control symptoms effectively. However, few studies have compared the efficacy and safety of d…
View article: Predictive significance of 15(S)-hydroxyeicosatetraenoic acid for eosinophilic chronic rhinosinusitis with nasal polyps
Predictive significance of 15(S)-hydroxyeicosatetraenoic acid for eosinophilic chronic rhinosinusitis with nasal polyps Open
Background: Among the different endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP), eosinophilic CRSwNP (ECRSwNP) exhibits more severe symptoms and a higher rate of recurrence compared with noneosinophilic CRSwNP (non-ECRSwNP),…
View article: Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis
Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis Open
Background An epidemiological association among asthma, blood eosinophil level and chronic rhinosinusitis (CRS) is well established, but whether consistent genetic relationships exist, and whether this reflects a shared genetic etiology be…
View article: Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps
Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps Open
Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of …
View article: Author Correction: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases
Author Correction: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases Open
View article: Effects of functional strength training on pain, function, and lower extremity biomechanics in patients with patellofemoral pain syndrome: a randomized clinical trial
Effects of functional strength training on pain, function, and lower extremity biomechanics in patients with patellofemoral pain syndrome: a randomized clinical trial Open
chictr.org.cn. NO: ChiCTR2400087664. Date 01/08/2024.
View article: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases
GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases Open
Inflammatory diseases are often chronic and recurrent, and current treatments do not typically remove underlying disease drivers1. T cells participate in a wide range of inflammatory diseases such as psoriasis2, Crohn…
View article: Stapokibart (CM310) in patients with uncontrolled seasonal allergic rhinitis (PHECDA): Rationale and design of a multicentre, randomized, double-blind, placebo-controlled study
Stapokibart (CM310) in patients with uncontrolled seasonal allergic rhinitis (PHECDA): Rationale and design of a multicentre, randomized, double-blind, placebo-controlled study Open
Background: Seasonal allergic rhinitis (SAR) is a global health issue, and the current standard of care (SoC) has limited effectiveness in controlling the disease. There is a need for innovative treatments to better manage uncontrolled SAR…
View article: Chinese Expert Consensus on the Impact of Ambient Air Pollution on Allergic Rhinitis and Recommendations for Mitigation Strategies
Chinese Expert Consensus on the Impact of Ambient Air Pollution on Allergic Rhinitis and Recommendations for Mitigation Strategies Open
Ambient air pollution poses a significant yet manageable threat to human health. The growing consensus on the impact of ambient air pollutants on allergic rhinitis (AR) emphasizes the importance of prevention, control, and treatment strate…
View article: Total immunoglobulin E levels in induced sputum reflect asthma control status
Total immunoglobulin E levels in induced sputum reflect asthma control status Open
Background Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects asthma control status has not been investigated. Methods Patients with asthma were classif…
View article: Dual-correlation sample selection and multi-scale sparse attention Transformer for battery state-of-health estimation
Dual-correlation sample selection and multi-scale sparse attention Transformer for battery state-of-health estimation Open
View article: M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps
M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps Open
Background Molecular signatures of chronic rhinosinusitis with nasal polyps (CRSwNP) related to macrophages remain unclear. This study aimed to develop a macrophage‐associated diagnostic signature for CRSwNP. Methods Transcriptome data fro…
View article: Aquatic therapy for spastic cerebral palsy: a scoping review
Aquatic therapy for spastic cerebral palsy: a scoping review Open
View article: The effectiveness of theta burst stimulation for motor recovery after stroke: a systematic review
The effectiveness of theta burst stimulation for motor recovery after stroke: a systematic review Open
Our results show that TBS has a good effect on improving motor function in stroke patients, but more large-scale, high-quality, multicenter studies are still necessary in the future to further clarify the mechanism of TBS and explore the o…
View article: DNA hypomethylation of Th17 cells by ambient particulate pollutants enhances neutrophil recruitment in murine models of allergic airway inflammation
DNA hypomethylation of Th17 cells by ambient particulate pollutants enhances neutrophil recruitment in murine models of allergic airway inflammation Open
View article: Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial
Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial Open
Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the…
View article: [Research progress of type 2 inflammation-related tissue remodeling in nasal polyps].
[Research progress of type 2 inflammation-related tissue remodeling in nasal polyps]. Open
Chronic rhinosinusitis with nasal polyps is a common chronic inflammatory disease with significant tissue remodeling, but the mechanism of remodeling remains unclear. Studies have shown that Type（T） 2 inflammatory network plays a c…
View article: Anti-IL-4Rα monoclonal antibody (CM310) in patients with chronic rhinosinusitis with nasal polyps (CROWNS-2): Rationale and design of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Anti-IL-4Rα monoclonal antibody (CM310) in patients with chronic rhinosinusitis with nasal polyps (CROWNS-2): Rationale and design of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study Open
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease that affects a large proportion of the global population. The treatment of CRSwNP, especially eosinophilic CRSwNP (ECRSwNP), has always been of great …
View article: Corrigendum to “Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning” [Environ. Int. 168 (2022) 107469]
Corrigendum to “Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning” [Environ. Int. 168 (2022) 107469] Open
View article: Efficacy of repetitive transcranial magnetic stimulation in post-stroke cognitive impairment: an overview of systematic reviews
Efficacy of repetitive transcranial magnetic stimulation in post-stroke cognitive impairment: an overview of systematic reviews Open
Objective The reliability of clinical evidence depends on high-quality meta-analyses/ systematic reviews (MAs/SRs). However, there has been no assessment of the quality of MAs/SRs for repetitive transcranial magnetic stimulation (rTMS) in …