Explanipedia

Data from ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation Open

Chao Shen, Yuan Che, Keren Zhou, Kitty Wang, Wei Li , et al. · 2025

Cancer cells utilize codon-biased translation to fuel tumorigenesis and drug resistance; however, underlying mechanisms remain poorly understood. In this study, we show that ALKBH1 is overexpressed in acute myeloid leukemia (AML) and essen…

Supplementary Figures S1-S7 from ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation Open

Chao Shen, Yuan Che, Keren Zhou, Kitty Wang, Wei Li , et al. · 2025

Supplementary Figure S1. ALKBH1 is required for human AML cell survival/growth in vitro and human AML progression in vivo. Supplementary Figure S2. ALKBH1 is required for leukemic cell transformation, LSC/LIC self-renewal and AML maintenan…

Supplementary Tables S1-S3 from ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation Open

Chao Shen, Yuan Che, Keren Zhou, Kitty Wang, Wei Li , et al. · 2025

Supplementary Table S1: Effects of ALKBH1 KD on f5C34 in mitochondrial tRNA-Met Supplementary Table S2: Genetic background of the AML patient samples. Supplementary Table S3: List of oligonucleotide sequences

Supplementary Proteomics Data 1 from ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation Open

Chao Shen, Yuan Che, Keren Zhou, Kitty Wang, Wei Li , et al. · 2025

Quantitative proteomics after ALKBH1 knockdown in MOLM13 cells.

ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation Open

Chao Shen, Yuan Che, Keren Zhou, Kitty Wang, Wei Li , et al. · 2025

Cancer cells utilize codon-biased translation to fuel tumorigenesis and drug resistance; however, underlying mechanisms remain poorly understood. In this study, we show that ALKBH1 is overexpressed in acute myeloid leukemia (AML) and essen…

PSPH promotes the proliferation and metastasis of esophageal squamous cell carcinoma through MAPK signaling pathways Open

Mengchu Yao, Yu Xie, Mingde Huang, Xiao Han, Yu Zhou , et al. · 2025

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited therapeutic options and poor prognosis, underscoring the urgent need for novel molecular targets. Here, we identify phosphoserine phosphatase (PSPH) as a ke…

PAXIP1 is regulated by NRF1 and is a prognosis‑related biomarker in hepatocellular carcinoma Open

Cheng Qian, Xiao Han, Hao Xie, Yan-Lin Liao, Fei Wang , et al. · 2024

Hepatocellular carcinoma (HCC) is characterized by a poor prognosis globally. PAX-interacting protein 1 (PAXIP1) serves a key role in the development of numerous human cancer types. Nevertheless, its specific involvement in HCC remains poo…

Harnessing m1A modification: a new frontier in cancer immunotherapy Open

Xinru Wang, Xiaoqing Ma, Siyu Chen, Minyan Fan, Chenying Jin , et al. · 2024

N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers). This modifi…

RBM15 increase tumor-infiltrating CD4+ T cell in ESCC via modulating of PLOD3 Open

Xuyang Lin, Xiao Han, Wubi Zhou, Xiaoxia Gong, Yu Zhou , et al. · 2024

RBM15 enhances tumor-infiltrating CD4+ T Cell abundance in ESCC by regulating PLOD3. Two new independent prognostic factors, PLOD3 and RBM15, may be useful in predicting the prognosis of ESCC.

Anti-reflux effects of a novel esophagogastric asymmetric anastomosis technique after laparoscopic proximal gastrectomy Open

Li-Qun Pang, Jie Zhang, Fang Shi, Cong Pang, Chengwan Zhang , et al. · 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current t…

A homozygous nonsense mutation in DNAJC30 causes Leber's hereditary optic neuropathy with Leigh-like phenotypes Open

Chao Shen, Kitty Wang, Wei Li, Álvaro Serrano, Kelly Powers , et al. · 2022

An Aggregation-Free Local Volume Fraction Formulation for Topological Design of Porous Structure Open

Kai Long, Zhuo Chen, Chengwan Zhang, Xiaoyu Yang, Nouman Saeed · 2021

Cellular structure can possess superior mechanical properties and low density simultaneously. Additive manufacturing has experienced substantial progress in the past decades, which promotes the popularity of such bone-like structure. This …

PTIP Inhibits Cell Invasion in Esophageal Squamous Cell Carcinoma via Modulation of EphA2 Expression Open

Xiao Han, Ya-Ning Zhu, Li Shen, Yu Zhou, Li-Qun Pang , et al. · 2021

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy and treatment failure is largely due to metastasis and invasion. Aberrant tumor cell adhesion is often associated with tumor progression and metastasis. However, t…

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia Open

Chengwan Zhang, Li Shen, Yifu Zhu, Ran Xu, Zhi-Kui Deng , et al. · 2021

Rationale: Despite landmark therapy of chronic myelogenous leukemia (CML) with tyrosine kinase inhibitors (TKIs), drug resistance remains problematic. Cancer pathogenesis involves epigenetic dysregulation and in particular, histone …

<i>BRCA</i> mutations and survival in breast cancer: an updated systematic review and meta-analysis Open

Yaning Zhu, Jian Wu, Chengwan Zhang, Suan Sun, Jian Zhang , et al. · 2016

BRCA mutations occur frequently in breast cancer (BC), but their prognostic impact on outcomes of BC has not been determined. We conducted an updated meta-analysis on the association between BRCA mutations and survival in patients with BC.…

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