Chuan Xia
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View article: Ceramide synthase 4 interferes with replication of influenza virus but is downregulated by infection
Ceramide synthase 4 interferes with replication of influenza virus but is downregulated by infection Open
Influenza continues to pose a serious threat to humans. Influenza-host interaction is incompletely understood, requiring identification of host factors that regulate viral pathogenicity. Ceramide synthases (CerSs) are responsible for produ…
View article: Alteration of the gut mycobiome in individuals with metabolically unhealthy obesity
Alteration of the gut mycobiome in individuals with metabolically unhealthy obesity Open
Background: Obesity is a heterogeneous condition, with some individuals remaining metabolically healthy (MHO) while others develop metabolically unhealthy obesity (MUO) characterized by metabolic syndrome and related complications. Althoug…
View article: Characteristic genes and immune infiltration analysis of gastric cancer based on bioinformatics analysis and machine learning
Characteristic genes and immune infiltration analysis of gastric cancer based on bioinformatics analysis and machine learning Open
View article: Positive Regulation of Cellular Proteins by Influenza Virus for Productive Infection
Positive Regulation of Cellular Proteins by Influenza Virus for Productive Infection Open
Influenza viruses cause annual epidemics and occasional pandemics through respiratory tract infections, giving rise to substantial morbidity and mortality worldwide. Influenza viruses extensively interact with host cellular proteins and ex…
View article: Functional analysis of TaEMF2 in regulating wheat heading date
Functional analysis of TaEMF2 in regulating wheat heading date Open
View article: Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses
Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses Open
Following infection, influenza viruses strive to establish a new host cellular environment optimized for efficient viral replication and propagation. Influenza viruses use or hijack numerous host factors and machinery not only to fulfill t…
View article: Comparative Analysis Reveals Different Evolutionary Fates and Biological Functions in Wheat Duplicated Genes (Triticum aestivum L.)
Comparative Analysis Reveals Different Evolutionary Fates and Biological Functions in Wheat Duplicated Genes (Triticum aestivum L.) Open
Wheat (Triticum aestivum L.) is a staple food crop that provides 20% of total human calorie consumption. Gene duplication has been considered to play an important role in evolution by providing new genetic resources. However, the evolution…
View article: Author Correction: Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat
Author Correction: Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat Open
View article: GSK3 regulates VRN1 to control flowering time in wheat
GSK3 regulates VRN1 to control flowering time in wheat Open
GLYCOGEN SYNTHASE KINASE 3 physically interacts with VRN1 and regulates its accumulation to mediate flowering in wheat.
View article: Genome sequencing of Sitopsis species provides insights into their contribution to the B subgenome of bread wheat
Genome sequencing of Sitopsis species provides insights into their contribution to the B subgenome of bread wheat Open
View article: Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat
Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat Open
View article: Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection
Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection Open
Influenza virus has the ability to circumvent host innate immune system through regulating certain host factors for its effective propagation. However, the detailed mechanism is still not fully understood. Here, we report that a host sphin…
View article: Development of magnetic particle-based chemiluminescence immunoassay for measurement of SARS-CoV-2 nucleocapsid protein
Development of magnetic particle-based chemiluminescence immunoassay for measurement of SARS-CoV-2 nucleocapsid protein Open
View article: Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus
Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus Open
Lytic replication of human cytomegalovirus (HCMV), a member of β-herpesvirus, is a highly complicated and organized process that requires its DNA polymerase processivity factor, UL44, the first-reported HCMV replication protein subjected t…
View article: Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Background Wheat is one of the most widely planted crops worldwide. The heading date is important for wheat environmental adaptability, as it not only controls flowering time but also determines the yield component in terms of grain number…
View article: Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response
Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response Open
View article: Additional file 17 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 17 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 17: Table S2. DEG information between WHd-A2.0 and MHd-A2.0, WHd-A3.5 and MHd-A3.5, WHd-L2.0 and MHd-L2.0, and WHd-L3.5 and MHd-L3.5.
View article: Additional file 18 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 18 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 18: Table S3. GO enrichment analysis of DEGs between the four groups.
View article: Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus
Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus Open
Lytic replication of human cytomegalovirus (HCMV), a member of β-herpesvirus, is a highly complicated and organized process that requires its DNA polymerase processivity factor, UL44, the first-reported HCMV replication protein subjected t…
View article: Additional file 19 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 19 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 19: Table S4. Detailed list of the MapMan annotations of the four groups of DEGs.
View article: Additional file 20 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 20 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 20: Table S5. Identification of transcription factors using differentially expressed genes.
View article: Additional file 22 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 22 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 22: Table S7. Sheet1:Sequences of primers used in qRT-PCR experiments. Sheet2: Relative expression data for the nine DEGs. Sheet3: FPKM values for the nine DEGs.
View article: Additional file 16 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 16 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 16: Table S1. Statistical data of each RNA-Seq sample, including read number, data size, Q30 value, GC content, and alignment results.
View article: Additional file 21 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Additional file 21 of Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Additional file 21: Table S6. Functional annotation of genes co-expressed with flowering time genes.
View article: Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date
Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date Open
Background: Wheat is one of the most widely planted crops worldwide. The heading date is important for wheat environmental adaptability; it not only controls flowering time but also determines the yield component in terms of the grain numb…
View article: WheatGmap: a comprehensive platform for wheat gene mapping and genomic studies
WheatGmap: a comprehensive platform for wheat gene mapping and genomic studies Open
View article: Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence Open
Chronic viral infections are often established by the exploitation of immune-regulatory mechanisms that result in nonfunctional T cell responses. Viruses that establish persistent infections remain a serious threat to human health. Sphingo…
View article: Combining a New Exome Capture Panel With an Effective varBScore Algorithm Accelerates BSA-Based Gene Cloning in Wheat
Combining a New Exome Capture Panel With an Effective varBScore Algorithm Accelerates BSA-Based Gene Cloning in Wheat Open
The discovery of functional genes underlying agronomic traits is of great importance for wheat improvement. Here we designed a new wheat exome capture probe panel based on IWGSC RefSeq v1.0 genome sequence information and developed an effe…
View article: The bZIP transcription factor TabZIP15 improves salt stress tolerance in wheat
The bZIP transcription factor TabZIP15 improves salt stress tolerance in wheat Open
As one of the most important staple foods, wheat plays a crucial role in sustaining food security. However, its production is greatly threatened by abiotic stresses such as salt (Khataar et al., 2018; Qi et al., 2019). Therefore, discoveri…
View article: Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice
Fructooligosaccharides supplementation mitigated chronic stress-induced intestinal barrier impairment and neuroinflammation in mice Open
Recently, accumulating evidence has suggested that gut microbiota is involved in modulating brain function and behavior through the gut-brain axis. Manipulation of gut microbiota by functional foods, such as prebiotics and probiotics, migh…