Explanipedia

Open-state structure of veratridine-activated human Na<sub>v</sub>1.7 reveals the molecular choreography of fast inactivation Open

Xiao Qun Fan, Jiaofeng Chen, Lulu Xue, Huan Wang, Tong Wu , et al. · 2025

Almost all the reported cryo-EM structures of eukaryotic voltage-gated sodium (Nav) channels, including those of human Nav1.1-Nav1.8, represent various inactivated states that are characteristic of a non-conductive pore domain (PD) surroun…

Consciousness and Reality: A Comparative Study of the Philosophical Foundationsof Marx and Hegel Open

Chen Song, Mengzhou Wu · 2025

This study offers a comparative analysis of the philosophical foundations of G. W. F. Hegel and Karl Marx with a focus on their respective conceptions of consciousness and reality. Drawing from classical texts and contemporary scholarship,…

Sleep neuroimaging: Review and future directions Open

Mariana Pereira, Xinyuan Chen, Anastasiya Paltarzhytskaya, Yibran Pacheсo, Nils Müller , et al. · 2025

Summary Sleep research has evolved considerably since the first sleep electroencephalography recordings in the 1930s and the discovery of well‐distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used …

Sleep on it: exploring the psychology of sleep amidst contemporary challenges Open

Kristina Denisova, Yuki Motomura, Chen Song · 2024

Throughout history, poets, scholars, and scientists have acknowledged the profound link between sleep and psychological well-being. The wisdom of “sleep on it”, ingrained in both Western and Eastern traditions, highlights the crucial role …

SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis Open

Yutong Li, Juntao Bie, Long Zhao, Chen Song, Tianzhuo Zhang , et al. · 2023

Imdet: Injecting More Supervision to Centernet-Like Object Detection Open

Shukun Jia, Chen Song, Yichao Cao, Xiaobo Lu · 2023

Sleep Neuroimaging: past research, present challenges and future directions Open

Mariana Pereira, Xinyuan Chen, Nils Müller, Leonore Bovy, Lei Xu , et al. · 2022

Sleep research has evolved considerably since the first sleep electroencephalography (EEG) recordings in the 1930s and the discovery of well-distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used to…

Mechanism of calcium permeation in a glutamate receptor ion channel Open

Florian Karl Schackert, Johann Biedermann, Saeid Abdolvand, Sonja Minniberger, Chen Song , et al. · 2022

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) are neurotransmitter-activated cation channels ubiquitously expressed in vertebrate brains. The regulation of calcium flux through the channel pore by RNA-editing i…

fMRI spectral signatures of sleep Open

Chen Song, Mélanie Boly, Enzo Tagliazucchi, Helmut Laufs, Giulio Tononi · 2022

Sleep can be distinguished from wake by changes in brain electrical activity, typically assessed using electroencephalography (EEG). The hallmark of nonrapid-eye-movement (NREM) sleep is the shift from high-frequency, low-amplitude wake EE…

Linking human behaviour to brain structure: further challenges and possible solutions Open

Chen Song, Kristian Sandberg, Renate Rutiku, Ryota Kanai · 2022

Calcium Permeation across the AMPA Receptor Channel: a Combined MD and QM/MM Study Open

Florian Karl Schackert, Johann Biedermann, Chen Song, Andrew J.R. Plested, Paolo Carloni , et al. · 2022

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) are neurotransmitter-activated cation channels ubiquitously expressed across vertebrate brains. The regulation of calcium flux through the channel pore by RNA-editi…

Brain structural complexity and consciousness Open

Chen Song · 2021

Structure shapes function. Understanding what is structurally special about the brain that allows it to generate consciousness remains a fundamental scientific challenge. Recently, advances in brain imaging techniques have made it possible…

123 Detrimental effects of acute sleep deprivation on perceptual metacognition Open

Marco Bigica, Chunxiang Jiang, Ilenia D’Onofrio, Zhishan Liu, Chen Song · 2021

Introduction Sleep deprivation (SD) impairs cognitive performance but its impact on metacognition – i.e. the ability to introspect about cognitive performance – is less clear. A few studies have assessed metacognitive accuracy after acute …

The Confidence Database Open

Dobromir Rahnev, Kobe Desender, Alan Lee, William T. Adler, David Aguilar‐Lleyda , et al. · 2020

Linking the nature and functions of sleep: insights from multimodal imaging of the sleeping brain Open

Chen Song, Enzo Tagliazucchi · 2019

Sleep and wakefulness are traditionally considered as two mutually exclusive states with contrasting behavioural manifestations and complementary neurobiological functions. However, the discoveries of local sleep in global wakefulness and …

The Confidence Database Open

Dobromir Rahnev, Kobe Desender, Alan Lee, William T. Adler, David Aguilar‐Lleyda , et al. · 2019

Understanding how people rate their confidence is critical for characterizing a wide range of perceptual, memory, motor, and cognitive processes. However, as in many other fields, progress has been slowed by the difficulty of collecting ne…

BOLD signatures of sleep Open

Chen Song, Mélanie Boly, Enzo Tagliazucchi, Helmut Laufs, Giulio Tononi · 2019

Sleep can be distinguished from wake by changes in brain electrical activity, typically assessed using electroencephalography (EEG). The hallmark of non-rapid-eye-movement sleep are two major EEG events: slow waves and spindles. Here we so…

Intra-hemispheric integration underlies perception of tilt illusion Open

Chen Song, Geraint Rees · 2018

Cultural effects on computational metrics of spatial and temporal context Open

Nicholas D. Wright, Jan Grohn, Chen Song, Geraint Rees, Rebecca Lawson · 2018

Human Occipital and Parietal GABA Selectively Influence Visual Perception of Orientation and Size Open

Chen Song, Kristian Sandberg, Lau M. Andersen, Jakob Udby Blicher, Geraint Rees · 2017

GABA is the primary inhibitory neurotransmitter in human brain. The level of GABA varies substantially across individuals, and this variability is associated with interindividual differences in visual perception. However, it remains unclea…

Plasticity in the Structure of Visual Space Open

Chen Song, Andrew Haun, Giulio Tononi · 2017

Visual space embodies all visual experiences, yet what determines the topographical structure of visual space remains unclear. Here we test a novel theoretical framework that proposes intrinsic lateral connections in the visual cortex as t…

Unconscious processing of invisible visual stimuli Open

Chen Song, Haishan Yao · 2016

Unconscious processing of subliminal visual information, as illustrated by the above-chance accuracy in discriminating invisible visual stimuli, is evident in both blindsight patients and healthy human observers. However, the dependence of…

Neural Population Tuning Links Visual Cortical Anatomy to Human Visual Perception Open

Chen Song, D. Samuel Schwarzkopf, Ryota Kanai, Geraint Rees · 2015

The anatomy of cerebral cortex is characterized by two genetically independent variables, cortical thickness and cortical surface area, that jointly determine cortical volume. It remains unclear how cortical anatomy might influence neural …

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