Explanipedia

Harnessing alternative splicing for off-the-shelf mRNA neoantigen vaccines in hepatocellular carcinoma Open

Haoliang Zhao, Yifei Cheng, Tiancheng Zhang, Qianxi Wang, Yanan Xu , et al. · 2025

Hepatocellular carcinoma (HCC) remains a major therapeutic challenge. Although targeting tumor-specific antigens represents a cornerstone of cancer immunotherapy, current approaches focus predominantly on mutation-derived neoantigens, whic…

Deep generative optimization of mRNA codon sequences for enhanced mRNA translation and therapeutic efficacy Open

Yupeng Li, Fan Wang, Lin‐Feng Chen, Hao Zhou, Tong Li , et al. · 2025

mrRNA-directed DNA methylation enables selective mutant oncogene silencing without exogenous proteins Open

Jie Gu, Yifan Guo, Ronghua Liu, Di Ge, Zhejun Pan , et al. · 2025

The outcome of recent demethylation therapy is limited by the unspecific hypomethylation of oncogenes. The mechanism underlying differential DNA methylation distribution in the same topological domain remains unclear. Here, we established …

Splicing Shift of <i>RAC1</i> Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer Open

Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang , et al. · 2025

Dysregulated RNA splicing has emerged as a pervasive yet understudied feature of cancer. The small GTPase RAC1 undergoes splicing changes in multiple cancers. However, the in vivo functional disparities between the two major RAC1 isoforms,…

Intravitreal injection of cell membrane-coated nanoparticles for retinoblastoma treatment Open

Yichi Zhang, Kaiqi Long, Ka Yi Lee, Jia Li, Shuting Xu , et al. · 2025

Chemotherapy is a widely adopted treatment for malignant intraocular tumors such as retinoblastoma. However, achieving high delivery efficiency remains challenging due to rapid clearance and lack of targeting specificity. Cancer cell membr…

Enhancing Immune Responses Through Modulation of Innate Cell Microenvironments in Lymph Nodes with Virus‐Mimetic Vaccines Open

Runping Su, Tingting Yao, Chong Cao, Yaqi Yang, Mingshan Chen , et al. · 2025

Nanovaccines hold significant promise for the prevention and treatment of infectious diseases. However, the efficacy of many nanovaccines is often limited by inadequate stimulation of both innate and adaptive immune responses. Herein, we e…

Enhancing Immune Responses Through Modulation of Innate Cell Microenvironments in Lymph Nodes with Virus‐Mimetic Vaccines Open

Runping Su, Tingting Yao, Chong Cao, Yaqi Yang, Mingshan Chen , et al. · 2025

Nanovaccines hold significant promise for the prevention and treatment of infectious diseases. However, the efficacy of many nanovaccines is often limited by inadequate stimulation of both innate and adaptive immune responses. Herein, we e…

Near-infrared fluorescence imaging with an MET-targeting probe for biopsy site selection in patients with oral potentially malignant disorders Open

Jingbo Wang, Xuemin Shen, Qifan Ma, Lin Yang, Xiaoyu Zhou , et al. · 2025

Ionizable polymeric micelles (IPMs) for efficient siRNA delivery Open

Ziyu Zhou, Feng Yu, Miao Jiang, Zhizhen Yao, Jing Wang , et al. · 2025

Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene gly…

Puerarin Suppresses Stat3 Ser727 Phosphorylation to Restore Mitochondrial Etc Activity and Delay the Inflammatory Progression of Atherosclerosis Open

Jinhua Xu, Xueshan Du, Changyou Zhan, Jingdan Liang, Zhe Li , et al. · 2025

Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein Open

Yulu Wang, Yifang Sun, Zhaoling Shen, Cong Wang, Jun Qian , et al. · 2024

Nipah virus infection, one of the top priority diseases recognized by the World Health Organization, underscores the urgent need to develop effective countermeasures against potential epidemics and pandemics. Here, we identify a fully huma…

Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies Open

Ercan Wu, Juan Guan, Yifei Yu, Shiqi Lin, Tianhao Ding , et al. · 2024

The different fate of liposomes among species has been discovered and mentioned in many studies, but the underlying mechanisms have not been explored. In the present work, we concentrated on the in vivo fate of PEGylated liposomes (…

Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin Open

寛鹿江, Kaisong Tian, Yifei Yu, Ercan Wu, Min Yang , et al. · 2024

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection Open

Wenjing Zai, Min Jae Yang, Kuan Jiang, Juan Guan, Huijing Wang , et al. · 2024

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explore combined RNA interference (…

Photoresponsive Drug Delivery Systems: Challenges and Progress Open

Yang Yang, Kaiqi Long, Yuxiu Chu, Huiping Lu, Weiping Wang , et al. · 2024

Photoresponsive drug delivery systems (PDDSs) have emerged as a promising toolbox for drug delivery, offering precise control over the site, duration, and dosage of light‐triggered medication. It allows controlled drug release, photo‐trigg…

Effects of Surface IR783 Density on the In Vivo Behavior and Imaging Performance of Liposomes Open

Qianqian Long, Xinmin Zhao, Lili Gao, Meng‐Yuan Liu, Feng Pan , et al. · 2024

Background: Nanoparticles conjugated with fluorescent probes have versatile applications, serving not only for targeted fluorescent imaging but also for evaluating the in vivo profiles of designed nanoparticles. However, the relationship b…

Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein Open

Tianlei Ying, Yulu Wang, Yifang Sun, Zhaoling Shen, Cong Wang , et al. · 2024

Nipah virus infection, one of the top priority diseases recognized by the World Health Organization, underscores the urgent need to develop effective countermeasures against potential epidemics and pandemics. Here, we identified a fully hu…

Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer Open

Qiwen Sun, Yuxiu Chu, Nana Zhang, Rui Chen, Lili Wang , et al. · 2024

The aberrant activation of the PI3K/mTOR signaling pathway is implicated in various human cancers. Thus, the development of inhibitors targeting mTOR has attracted considerable attention. In this study, we used a structure-based drug desig…

Reexamining the effects of drug loading on the in vivo performance of PEGylated liposomal doxorubicin Open

Yifei Yu, Ercan Wu, Shiqi Lin, Yuxiu Chu, Yang Yang , et al. · 2023

mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion Open

Huan Wang, Zhuxuan Jiang, Zhiwei Guo, Gan Luo, Tianhao Ding , et al. · 2023

Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities Open

Huan Wang, Shiqi Lin, Xiying Wu, Kuan Jiang, Huiping Lu , et al. · 2023

Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in t…

Protein corona mediated liposomal drug delivery for bacterial infection management Open

Qianwen Shao, Tianhao Ding, Feng Pan, Guanghui Li, Shun Shen , et al. · 2022

H<sub>2</sub>S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors (Adv. Therap. 9/2022) Open

Kaiqi Long, Yang Yang, Zhanfeng Du, Weirong Kang, Wen Lv , et al. · 2022

In article number 2200044, Weiping Wang and co-workers developed a H2S-responsive nanocarrier based on the self-assembly of trigonal small molecules. Hydrophobic drugs, such as doxorubicin, can be encapsulated and precisely released in the…

Evaluation of CTB-sLip for Targeting Lung Metastasis of Colorectal Cancer Open

Xiaoying Zhang, Wenjing Tang, Haoyu Wen, Ercan Wu, Tianhao Ding , et al. · 2022

Lung metastasis of colorectal cancer is common in the clinic; however, precise targeting for the diagnosis and therapy purposes of those lung metastases remains challenging. Herein, cholera toxin subunit b (CTB) protein was chemically conj…

Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy Open

Kaiqi Long, Yifan Wang, Wen Lv, Yang Yang, Shuting Xu , et al. · 2022

Photocleavable prodrugs enable controllable drug delivery to target sites modulated by light irradiation. However, the in vivo utility is usually hindered by their insolubility and inefficient delivery. In this study, we report a simple st…

Engineered platelets-based drug delivery platform for targeted thrombolysis Open

Songli Wang, Ruifeng Wang, Nana Meng, Linwei Lu, Jun Wang , et al. · 2022

Thrombolytic agents have thus far yielded limited therapeutic benefits in the treatment of thrombotic disease due to their short half-life, low targeting ability, and association with serious adverse reactions, such as bleeding complicatio…

Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma (Adv. Sci. 20/2021) Open

Kaiqi Long, Yang Yang, Wen Lv, Kuan Jiang, Yafei Li , et al. · 2021

Light‐Triggered Drug Release In article number 2101754, Changyou Zhan, Weiping Wang, and co‐workers develop an “intravenous injection plus light‐triggered intraocular drug release” strategy to achieve drug accumulation in retinoblastoma. T…

Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma Open

Kaiqi Long, Yang Yang, Wen Lv, Kuan Jiang, Yafei Li , et al. · 2021

Retinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also l…

Topical instillation of cell-penetrating peptide-conjugated melphalan blocks metastases of retinoblastoma Open

Kuan Jiang, Xingyan Fan, Yang Hu, Sheng-Yu Yao, Yu Liu , et al. · 2021

Retinoblastoma is the most common primary intraocular malignancy in infancy with a metastases-related death risk. However, a safe and convenient treatment without enucleation is still an unmet clinical need. In this work, a cell-penetratin…

Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models Open

You Li, Huifang Wu, Gang Chen, Xiaofan Wei, Chunyu Wang , et al. · 2020

Glioblastoma (GBM) is an aggressive malignancy with poor prognosis. New therapeutic strategies for GBM are urgently needed. Although clinical studies have demonstrated the feasibility and safety of chimeric antigen receptor (CAR) T cell th…

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