Chengying Huang
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View article: Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment Open
Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurren…
View article: Enhancing liquid biopsies are a promising approach for the early detection of cancer
Enhancing liquid biopsies are a promising approach for the early detection of cancer Open
Cancer is a formidable threat to human life, a cure for which in advanced stages remains challenging. Early detection and treatment of cancer are paramount, yet a substantial number of cancer patients receive diagnoses at an advanced stage…
View article: MSCT-UNET: multi-scale contrastive transformer within U-shaped network for medical image segmentation
MSCT-UNET: multi-scale contrastive transformer within U-shaped network for medical image segmentation Open
Objective. Automatic mutli-organ segmentation from anotomical images is essential in disease diagnosis and treatment planning. The U-shaped neural network with encoder–decoder has achieved great success in various segmentation tasks. Howev…
View article: Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder
Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder Open
Depression is a major contributor to poor global health and disability, with a recently increasing incidence. Although drug therapy is commonly used to treat depression, conventional antidepressant drugs have several disadvantages, includi…
View article: The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide
The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide Open
Nuclear receptor coactivator 4 (NCOA4) protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to lysosomes for degradation and releasing iron. TRIM7 o…
View article: The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide
The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide Open
View article: OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration
OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration Open
The low response rate to immunosuppressant is mainly due to the lack of adequate knowledge about the tumor microenvironment (TME) and screening biomarkers for gliomas. We aimed to identify the promising immune biomarkers and new immune cla…
View article: Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells
Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells Open
As a transcription factor, the role of CASZ1 in different entities is inconsistent. Glioma is one of the leading causes of cancer death worldwide. Its prognostic relevance and biological functions in glioma remain obscure. We focused on th…
View article: An integrated analysis of <i>C5AR2</i> related to malignant properties and immune infiltration of gliomas
An integrated analysis of <i>C5AR2</i> related to malignant properties and immune infiltration of gliomas Open
Background C5AR2 is recognized as a proinflammatory molecule and activates the inflammatory response in multiple disorders. However, little has been reported on C5AR2 in glioma. This study sought to explore its expression, biological funct…
View article: Roles of Tenascin-XB in the Glioma Immune Microenvironment
Roles of Tenascin-XB in the Glioma Immune Microenvironment Open
Background: Previous studies have reported the critical roles of tumor cells and the tumor microenvironment in tumor prognosis and immunotherapeutic response. However, how Tenascin-XB (TNXB) expression relates to glioma prognosis and to th…
View article: Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance Open